舰船基座设计研究

探讨了舰船基座的一般设计准则，介绍了一些典型舰船的基座设计，分析研究了舰船基座的计算设计方法和舰船基座的试验研究方法，提出了舰船基座设计的一般步骤。     

军用软件质量及其测试的探讨

随着计算机科学的发展，推动着信息化战争的不断发展。提高了对军事装备的性能要求，进而加强了对军用软件的质量要求。强调用软件测试技术提高军用软件质量。     

舰船结构可靠性的定性设计方法

提出一种舰船结构可靠性的定性设计方法，在分析故障及其影响的基础上，不断改进设计、消除故障并提出质量控制、使用限制及防救措施的方案，可以保证对舰船结构可靠性的定性要求。     

离散最大值原理在系统可靠性中的应用

给出一种受多个非线性约束条件限制的多级并行系统可靠性优化计算方法，这种方法适用于约束函数可分的情况，其特点是计算简单，容易实现计算机自动处理。     

智能化卷缆装置——变频电缆卷筒

结合起重机械对电缆卷筒的性能要求,着重介绍变频电缆卷筒的工作原理和控制方法.针对目前国际上采用变频方法控制的电缆卷筒,提出了新颖的、高集成度的控制思路,研制出性能优越的新型变频电缆卷筒,在实际应用中取得了良好的效果.     

滚装客船市场状况浅析

本文通过分析滚装客船的特点和发展趋势以及国内外滚装客船的建造现状，说明滚装客船有比较好的市场前景，是值得我国重点发展的船型之一。     

Multimode trip information detection using personal trajectory data

Handheld global positioning system (GPS) devices can serve as a new tool to collect an individual's trip information with advantages of low cost, accurate data, and intensive spatial coverage. Various machine learning algorithms have been explored to detected trip train information in previous studies; however, few of them focused on the evaluation and comparison of the performance and applicability of different models. Meanwhile, according to previous studies, car and bus mode detection is a thorny issue due to their similar travel characteristics, and algorithms still need to be well explored and improved to solve this problem. In this article, an innovative method is proposed to detect trip information, including trip modes, mode-changing time and location, and other attributes, from personal trajectory data. The method is a two-step process. A machine learning algorith-based module (including artificial neural network, support vector machine, random forests, and Bayesian network) is firstly used to identify walk, bicycle, and motorized trip modes (bus or car); we thoroughly compared the performance of these four algorithms. Then a second module, using critical points on the GPS trajectories, is further developed to distinguish car and bus mode, incorporated with GIS map information. Field test results show that the proposed machine learning models can all be applied for walk, bicycle, and motorized mode detection with high detection rates exceeding 90%; however, the algorithms work relatively poorly for bus and car mode detection, with results mostly below 75%. The proposed two-step method can greatly improve bus and car mode detection accuracy by 14–30%. As a result, the average mode detection rates for all the four modes are above 90%. Compared with mode detection results by using only the machine learning algorithm, the proposed two-step method has much better performance in both accuracy and consistency.     

环氧合酶-2和ki-67在宫颈鳞状细胞癌组织中的表达

目的研究环氧合酶-2(COX-2)和ki-67在慢性宫颈炎、宫颈上皮内瘤样变(CIN)、宫颈鳞状细胞癌(SCC)中的表达及其相关性。方法RT-PCR法检测COX-2 mRNA在正常、炎性、CIN组织和SCC组织中的表达;免疫组化法检测各组中COX-2和ki-67蛋白的表达。结果COX-2 mRNA和蛋白在正常组无表达,在炎性、CIN和SCC组表达升高(P<0.05),COX-2蛋白的表达与肿瘤体积和浸润深度有关(P<0.05)。ki-67在正常组中偶有表达,在炎性组和CIN组表达增高,在SCC组显著增高(P<0.01)。COX-2与ki-67蛋白的表达相关(r=0.675,P<0.001)。结论COX-2表达增高可能是宫颈癌发生发展的早期事件,与细胞异常增生有关。     

氧化苦参碱对慢性肾脏病患者血清MMP-9和TIMP-1的影响

目的观察氧化苦参碱对慢性肾脏病(CKD)患者血清基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶组织抑制因子-1(TIMP-1)的影响,探讨其在肾间质纤维化发生发展过程中的作用和治疗价值。方法选取健康对照者10例、慢性肾脏病患者40例,根据肾小球滤过率(GFR)分为轻度肾损害组(GFR<90 mL/min.1.73 m2,CKDⅠ)和中、重度肾损害组(GFR<60 mL/min.1.73 m2,CKDⅡ),再分层随机抽样,分为常规治疗组和氧化苦参碱组。利用双抗体夹心酶联免疫吸附法分别检测各组治疗前后血清MMP-9和TIMP-1含量,采用t检验比较两组MMP-9和TIMP-1水平的差异。结果经氧化苦参碱干预后,TIMP-1水平显著低于常规治疗组,而MMP-9水平则显著高于常规治疗组(P<0.05)。结论氧化苦参碱可下调TIMP-1水平,恢复MMP-9水平,保持MMP-9/TIMP-1平衡,减少细胞外基质(ECM)沉积,防止肾间质纤维化。     

地铁车站与周边开发共建的差异沉降控制分析

阐述了地铁设施变形控制标准及共建建筑的差异沉降机理和规律。介绍了沉降计算方法和控制差异沉降的设计方法。结合上海轨道交通某地下车站与大型地下室共建、实施一体化设计施工的工程实践来探讨地铁车站与开发地块建筑共建的差异沉降控制技术。研究表明,选择合理的沉降计算方法及参数对工程差异沉降进行预估分析,并根据分析结果在设计上采取相应的技术措施,可将综合工程对地铁车站产生的差异沉降影响控制在地铁设施保护要求范围之内。