土工格栅加筋路堤影响因素研究

在野外修筑了4段连为一体的试验路堤,其中3段含土工格栅加筋层,格栅层间距各不相同.用土压力盒测量了每段路堤底部的竖向土压力.在试验研究的基础上建立有限元模型,模型得到了试验数据的验证.用该模型对土工格栅加筋路堤进行了计算分析,探讨了加筋层间距以及路堤土的内摩擦角、粘聚力和弹性模量对加筋路堤沉降和应力分布的影响规律.得到以下主要结论:(1)加筋路堤的表面沉降随格栅层间距的减小而减小,其根本原因是加筋路堤内部的竖向应力随格栅层间距的减小而降低,而水平应力却随之增加;(2)加筋路堤的整体性和竖向变形的均匀性随格栅层间距的减小而提高,这有利于改善路面结构的受力和变形条件,从而延长路面的使用寿命.     

基于小波变换与支持向量机的舰船水压信号检测方法

采用小波变换与支持向量机相结合对舰船水压场信号建立检测模型.该方法通过对海浪信号进行小波分解并对某一特定低频频段信号重构,利用支持向量机对重构信号建立预测模型,预测误差值作为特征值对舰船水压信号进行检测.通过检测验算表明此方法的有效性,特别是在低信噪比情况下,仍能较好地检测到目标信号.     

基于HLA的船用压水堆运行控制仿真实现

仿真系统在HLA规范下,利用VR-Link/RTI构建分布式网络平台,在VC 程序中对MATLAB和Vega进行联邦成员的改写实现了船用反应堆主回路系统的虚拟仿真.HLA技术的可扩充性和复用性使基于HLA的船用反应堆运行控制仿真能够扩充并能够很好地复用到船用核动力系统虚拟仿真乃至整船的航行控制虚拟仿真中去,是其重要的基础工作.     

VEGF-C、VEGFR-3和podoplanin在食管癌中的表达及其意义

目的观察血管内皮生长因子C(VEGF-C)及其受体3(VEGFR-3)和肾小球上皮细胞整合膜蛋白(podoplanin)在食管癌组织中的表达,分析其与肿瘤淋巴结转移的关系。方法免疫组织化学SP法检测76例食管癌组织中VEGF-C、VEGFR-3和podoplanin的表达及淋巴管密度(LVD)。结果食管癌VEGF-C表达阳性率为63.1%,VEGF-C的表达与食管癌的淋巴结转移、TNM分期有统计学意义(P<0.01,P<0.05),但与患者年龄、肿瘤大小及分化程度无关;癌旁组织淋巴管密度同淋巴结转移、VEGF-C阳性表达间有统计学意义(P<0.01,P<0.05),podo-planin LVD值与VEGFR-3 LVD值相比,具有统计学意义(P<0.01)。结论食管癌组织中VEGF-C表达与肿瘤TNM分期、淋巴管密度和淋巴结转移有关,VEGF-C表达越高,淋巴管密度越大,淋巴结转移可能性越高。癌旁组织LVD同VEGF-C的高表达及淋巴结转移密切相关,食管癌组织中podoplanin标记的淋巴管密度较VEGFR-3标记的淋巴管密度更为精确,是一种更为满意的淋巴管内皮特异性标志物。     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

Role of candesartan against cerebral ischemia and oxidative damage in normotensive rats

Objective Angiotensin Ⅱ (Ang Ⅱ ) contributes to modulating blood pressure by stimulation of Ang Ⅱ AT1 receptors. We devised a rat transient middle cerebral artery occlusion (MCAO) model to assess whether oxidative damage is decreased after pretreatment with Angiotensin Ⅱ AT1 receptor blocker (ARB). Methods After 2 weeks pretreatment with ARB 0. 5 and 1 mg/kg, the male Wister rats were subjected to 2 h middle cerebral artery occlusion (MCAO). At 24 h, the lumen diameter of middle cerebral artery, the plasma level of 8-hydroxy-2'-deoxyguanosine (8-OHdG), and HIF-1 a levels were recorded and compared. Results After pretrcatment with ARB 0.5 and 1 mg/kg, blood pressure did not significantly change compared with that of controls. In the group of candesartan at 1 mg/(kg· day), the lumen diameter was significantly increased compared to that in control group [(86.0±5.0) μm vs. (69.0± 2.1) μm; P<0. 01, n = 6- 8]. The plasma 8-OHdG levels of ARB pretreatment groups were decreased. In immunohistochemical findings, 8-OHdG- and HIF-1α-containing cells in ARB pretreatment groups were decreased. Conclusion Brain ischemia and oxidative damage can be reversed by AT1 receptor blockade in normotensive rats after transient cerebral artery occlusion.     

The role of interleukin-8 produced by tumor induced fibroblasts in the development of cutaneous melanoma

Objective To determine the role of interleukin-8 (IL-8) produced by tumor induced fibroblasts in the development of cutaneous melanoma. Methods B16 melanoma cells induced L929 fibroblasts phenotype was transdifferentiated to myofibroblasts (MF) by co-culture in vitro. MF was monitored by morphology and immunophenotype for a-SMA. The level of IL-8 was detected by ELISA. The effect on B16 cell proliferation rate was estimated using MIT method in vitro. Melanoma implanting model was constructed in C57 mice. Results L929 MF phenotype could be modulated by B16 melanoma cells-derived transforming growth factor-β1 (TGF-β1) and elevated the levels of IL-8. L929 MF did not influence the B16 melanoma cells viability in vitro, but shortened the time of tumor formation and increased the incidence rates of tumors in C57 implanting model mice. Conclusion Fibroblasts can be activated by tumor cells and produce IL-8, which acts as an inflammatory cytokine promoting the development of cutaneous melanoma.     

A bintree energy approach for colour image segmentation using adaptive channel selection

A new hierarchical approach called bintree energy segmentation was presented for color image segmentation. The image features are extracted by adaptive clustering on multi-channel data at each level and used as the criteria to dynamically select the best chromatic channel, where the segmentation is carried out. In this approach, an extended direct energy computation method based on the Chan-Vese model was proposed to segment the selected channel, and the segmentation outputs are then fused with other channels into new images, from which a new channel with better features is selected for the second round segmentation. This procedure is repeated until the preset condition is met. Finally, a binary segmentation tree is formed, in which each leaf represents a class of objects with a distinctive color. To facilitate the data organization, image background is employed in segmentation and channels fusion. The bintree energy segmentation exploits color information involved in all channels data and tries to optimize the global segmentation result by choosing the ＂best＂ channel for segmentation at each level. The experiments show that the method is effective in speed, accuracy and flexibility.     

舰船电力推进电机性能剖析

介绍了综合电力推进的概念、研究发展动态以及舰船电力推进电机的特殊性能要求,剖析了先进感应电机、轴向磁通永磁电机、横向磁通永磁电机、高温超导电机等高性能推进电机的性能特点、拓扑结构及关键技术.在分析推进电机研究应用现状的基础上对其未来发展进行了展望.     

用于模拟螺旋桨负载的双馈电机矢量控制研究

螺旋桨负载模拟是舰船电力推进系统中的重要研究内容.文中利用双馈电机四象限运行以及通过转子侧控制能降低变频器容量的特性,提出了双馈电机能量反馈系统模拟螺旋桨负载特性的方案.采用定子磁链定向的矢量控制策略,利用MATLAB/SIMULINK建立双馈电机模型和控制系统模型,实现不同工况下的稳态和动态特性模拟.仿真结果表明,转矩响应迅速、准确、稳定,采用矢量控制的双馈电机能量回馈系统具有良好的四象限负载特性模拟性能.