基于机载LiDAR数据构建的DEM抽稀算法研究

LiDAR数据构建的DEM数据量庞大,给数据的存储和处理带来诸多不便。如何对DEM进行抽稀,得到一个易于处理和操作的DEM是一个值得研究的问题。在分析、对比国内外多种DEM抽稀方法的基础上,提出了基于坡度的抽稀算法。实验表明,基于坡度的抽稀算法能够得到较好的抽稀结果,且对DEM精度影响较小。     

siRNA AGAINST SURVIVIN SUPPRESSES THE PROLIFERATION OF PANCREATIC CANCER CELL PC-2 AND INDUCES ITS APOPTOSIS

Survivinis a member of the inhibitor of apop-tosis family,whichinhibits cell apoptosis and regu-lates cell division.Survivin is expressed in embry-onic tissues as well as in the majority of humancancers,but is not expressed in most nor mal adulttissues.The highly cancer-specific expression ofSurvivin,coupled withits i mportance in inhibitingcell apoptosis and in regulating cell division,makesit a useful diagnostic marker and ideal target forcancer treat ment[1].RNAi is a process of post trans…     

THE HUMORAL AND CELLULAR IMMUNE RESPONSES INDUCED BY HPV18L1-E6/E7 DNA VACCINES IN MICE

Objective To construct eukaryutic expression vector of HPV18 L1- E6, E7 chimeric gene and examine the humorul and cellular immune responses induced by this DNA vaccines in mice. Methods The C-terminal of major rapsid protein L1 gene and mutant zinc finger domains of early E6/7 oncogenes in HPV18 were integrated and inserted into eukaryotic expression vector pVAX1 to generate vaccines pVAX1-L1E6Mxx, ETMxx. CHO cells were transiently transfected with the individual construct. Target protein expressions in the lysate of the transfected cells were measured by ELISA and immunocytochemistry After BALB/c mice were vaccinated with various recombinant plusmids（pVAX1- L1-E6M3 or pVAX1-L1-E7M3 ） and immunie adjuvants （pLXHDmB7-2 or LTB） through different administration routes （intramuscular or intranasal） , the great cellular immune responses were produced us revealed by delayed-type hypersensitivity （DTH） and lymphocyte proliferation, and the expression of IL-4 and IFN- 7 cells in CD4^＋ and CD8^＋ subpopulations. Results The highly efficient expression of pVAX1-L1E6Mxx, E7Mxx vector in host eukaryotic cells were demonstrated both by ELISA and immunocytochemistry. The level of specific serum IgG against HPV in experiment groups mice was much higher than that of control group, and intranuscular immunization group had the highest antibody level. Intramuscular immunization groups were superior to intranasal immunization groups in DTH response, splenocyte proliferation and CD8^＋ IFN-γ^＋ cells number, but CD4^＋ IL4^＋ cell number was higher in intranasul immunization groups. The immunization groups using pLXHDmB7.-2 as adjuvant were superior to other groups in immunorespouse. Conclusion These DNA vaccines produce remarkable cellular and humorul immune responses in the mouse and may provide us prophylatic and therapeutic candidates for HPV induced cancer treatment.     

HOV车道的设计应用研究

随着我国汽车工业的不断发展，城市的机动车数量不断增加，在带来经济效益的同时，也产生了许多交通问题。通过对HOV设计应用的研究，阐述了在我国目前的发展形势下，将HOV理念引入城市交通管理是实现城市道路可持续发展的需要，也是城市用地集约化配置的需要；同时指出，我国实行HOV优先的可能。论文借鉴多方式出行选择Iogit模型对HOV车道的设置进行了探讨。     

On the perceived justice of urban road pricing: An empirical study in Lyon

Various methods of restricting automobile traffic, by price (tolls) or by quantity (odd/even license plates or limited days of traffic), are tested in a survey (N ～ 400) about attitudes toward traffic restrictions in Lyon, France. Ordered probit models with random-effects panel allow us to estimate the survey respondents’ perceptions of these methods, as well as the roles of individual socio-demographic characteristics in the formation of these perceptions. Both the restriction of automobile traffic and its regulation by congestion (waiting in line) are widely considered unjust by the respondents, regardless of whether they work and whether they are drivers or non-drivers. Their attitudes towards tolls justified by the pollution caused by automobile traffic are less negative. As regards compensation, in addition to emergency vehicles and those that transport people with limited mobility, respondents believe car-pooling ought to benefit of a toll exemption. The support for a reduced rate for low-income users shows a concern for justice to which it will be necessary to respond. The respondents’ socio-professional status, level of education, car use or non-use, and residence inside or outside of the toll zone clearly play a role in their perceptions of these methods of regulation and compensation.     

Impact of different shopping stages on shopping-related travel behaviour: analyses of the Netherlands Mobility Panel data

From the moment e-shopping emerged, there have been speculations about its impact on personal mobility. A fair amount of research has already been carried out on Internet shopping itself as well as on its consequences for mobility. Most studies focus on the overall impact of online shopping on personal mobility. However, little is known about how personal shopping mobility can be characterised when differentiating its constituent stages, being browsing/orienting, comparing, selecting and purchasing products, and how this is affected by e-shopping. This will be the main topic of this paper. We will investigate this using recently collected data from the Netherlands Mobility Panel [in Dutch: MobiliteitsPanel Nederland (MPN)]. It is the unique combination of reported shopping trips in the three-day travel diary, the large amount of personal and household characteristics combined with the detailed information from the e-shopping questionnaire that enables us to perform this research. Using factor analysis, we explore the underlying factors related to the browsing and selection behaviour prior to the purchase of a product. Using these factors as a starting point, we apply cluster analysis resulting in three homogeneous groups of shoppers with different pre-purchase shopping behaviour. The groups differ clearly with respect to personal and household characteristics, in the frequency with which they buy and sell products online and in their perception of (dis-)advantages of online shopping. Once relevant groups have been distinguished and characterised, differences in shopping-related mobility between them are studied in two different ways. Firstly, we analyse statements from shoppers on how their shopping-related mobility has changed. Secondly, we analyse shopping trips reported in the three-day travel diary. Only one group, which consists of shoppers that rely on the Internet to search for product information, compare prices and get new product ideas, states that their shopping-related travel behaviour has changed since they started shopping online. Approximately 50% of all shoppers experienced no difference in their shopping mobility. The analysis of actual shopping mobility using the travel diary data showed only minor differences in shopping-related travel behaviour between the identified groups. Finally, we fit a multi-variate linear regression model of shopping trip distance to determine if (e)-shopping characteristics influence trip distances. The frequency with which people shop online as well as some stated changes in shopping-related travel behaviour (shopping in a similar manner and shopping longer) turn out to influence non-grocery shopping trip distance. No significant influence could be found of shopping cluster membership on shopping trip distances.

     

A fractional perspective to the modelling of Lisbon’s public transportation network

Transportation - Urban growth originates multiscale spatial patterns, such as those of transportation networks. Here, the public transportation network (PTN) of the city of Lisbon is analysed from...     

Determining bicycle infrastructure preferences – A case study of Dublin

This paper examines infrastructure preferences for cyclists and determines the factors that have the greatest influence on the correlation between the level of cycling confidence and preferred types of infrastructure and route characteristics. A stated preference survey is used to gauge preferences for a range of infrastructure types and route characteristics in Dublin. Facilities that were segregated from traffic are the preferred form of cycling infrastructure, regardless of cycling confidence. Routes through residential streets and parks are the second choice, where no specific infrastructure is provided with the exception of improvements in way-finding.     

A velocity and payload dependent emission model for heavy-duty road freight transportation

The paper develops a forecasting model of emissions from traffic flows embracing the dynamics of driving behavior due to variations in payload. To measure of emissions at the level of individual vehicles under varying payloads a portable emission measurement system is used. This paper reports on a model based on data at the level of individual vehicles for a representative road trajectory. The model aggregates the data to the level of a homogeneous flow dependent of velocity and specific power, which is dependent on payload weight. We find a lean specification for the model that provides emission factors for CO₂, NO_x, HC, CO, and NO₂. The results indicate that, in comparison with earlier models, NO_x emissions in particular tend to be underestimated.     

Assessment of Vulnerability and Integrated Management of Coastal Dunes in Veracruz,Mexico

Dune systems are essential to the ecological balance and sediment inputs of coastal environments and they provide numerous environmental services; however, their existence is threatened by natural and human stressors that contribute to their degradation. Future impacts are expected to be greater because of global climate change in association with further rises in sea level. Beaches and dune systems occupy large areas along the coastline of the state of Veracruz on the Gulf of Mexico. The aim of this study is to establish the intrinsic vulnerability of nine dune fields in Veracruz to current and future impacts and to assess their integrated management status. These dune–beach systems are more vulnerable to the effects of economic activities and land use change than to those induced by natural forces. Results show that six of these dune systems have medium vulnerability and an ecological conservation policy should be adopted; the other three, with high or very high vulnerability, are candidates for a restoration policy.