监测空气中的微生物

可靠有效的监控无菌室洁净室和监管区的空气质量是生物技术或制药业环境规划中重要的一部分。这不仅是美国和欧洲的良好生产规范（GMP）要求，而且提供了生产期间环境聩量管理的重要信息。此外，持续-陛监测能使操作人员发现微生物污染空气的趋向性，授予其权力给予干涉。并在必要时发表紧急情况的声明。     

Travel plans for new developments: a global review

A travel plan is a mechanism for delivering a package of transport measures at a site to manage car use and encourage the use of more sustainable forms of transport. In recent years, travel plans have been required for new infill and greenfield developments through the land-use planning and approvals process, predominantly in the United Kingdom, the United States, continental Europe and Australia. This paper contributes to the literature by providing a global review of travel plans for new developments. The results show that while travel plans for new developments share a common set of elements with those for pre-existing sites, differences within each element are notable, particularly in the types of travel plan measures adopted, processes for managing the travel plan, and approaches to monitoring and review. Results of previous evaluations have varied considerably, although most have reported a reduction in car driver trips of 10–20 percentage points. Despite this, most evaluations lack rigour, with a paucity of robust evidence. Key success factors identified by the literature, such as the provision of an explicit policy supporting the role of travel plans, should be embedded within the travel planning process where possible to ensure best outcomes for new developments.     

Large eddy simulations for quasi-2D turbulence in shallow flows: A comparison between different subgrid scale models

In this study, the performance of the horizontal large eddy simulation module, developed at the University of Leuven (HLES-KULeuven module) is assessed. A comparison between different subgrid scale models has been carried out. The study is concerned with the non-rotating and unstratified flows. The results of the simulation for an oscillatory backward facing (BFS) flow are presented in case of an expanding flume based on a one-length scale approach and a two-length scale approach. Three subgrid scale (SGS) models have been tested: Smagorinsky SGS model (Smagorinsky, J., (1963). General circulation experiments with the primitive equations, I. the basic experiments. Monthly Weather Review, 91(3), 99–164), Uittenbogaard SGS model (Uittenbogaard, R.E., and van Vossen, B., (2004). Subgrid-scale model for quasi-2D turbulence in shallow water. Shallow Flows. Jirka and Uijttewaal (Eds.), Taylor & Francis Group, London, ISBN 90 5809 700 5) and a proposed two-length scale approach. The first two models are considered to be a one-length scale models. A simulation without a subgrid scale model for the horizontal mixing has also been conducted. In all simulations, a quadratic friction model parameterizes the dissipation produced by the 3D-subdepth scale turbulence. The two-length scale concept uses a newly mixing length formulation for the quasi-2D turbulence and doesn't depend on the filter width in contrast to the one-length scale approach, in which the mixing length is function of the filter width. The outputs of the HLES-KULeuven module have been compared with the experimental data taken from Stelling, G.S., and Wang, L.X., (1984). Experiments and computations on separating flow in an expanding flume. Dept. Civil Engineering, Delft University of Technology, Report 2–84.). The two-length scale approach has been validated with experimental data from SERC Flood Channel Facility at HR Wallingford. In general, there is a qualitative agreement with the experimental data. It has also been found that the two-length scale approach produces more elongated and less isotropic vortex than the one-length scale models.     

Assessment of large transport infrastructure projects: The CBA-DK model

This paper presents a newly developed decision support model to assess transport infrastructure projects: CBA-DK. The model combines use of conventional cost–benefit analysis to produce aggregated single point estimates, with quantitative risk analysis using Monte Carlo simulation to produce interval results. The embedded uncertainties within traditional CBA such as ex-ante based investment costs and travel time savings are of particular concern. The paper investigates these two impacts in terms of the Optimism Bias principle which is used to take account of the underestimation of construction costs and the overestimation of travel time savings. The CBA-DK methodological approach has been used to apply suitable probability distribution functions on the uncertain parameters, thus resulting in feasibility risk assessment moving from point to interval results. The proposed assessment model makes use of both deterministic and stochastic based information. Decision support as illustrated in this paper aims to provide assistance in the development and ultimately the choice of action, while accounting for the uncertainties surrounding transport appraisal schemes. The modelling framework is illustrated by the use of a case study appraising airport and runway alternatives in the capital of Greenland – Nuuk. The case study has been conducted in cooperation with the Home Rule Authorities of Greenland.     

Book reviews

Road haulage licensing and EC Transport Policy. By K. J. Button. (Aldershot: Gower Publishing Co., 1984.) [Pp.127.] £14.50.

Bicycles and Public Transportation: New Links to Suburban Transit Markets. By Michael A. Replogle. (Bicycle Federation, Washington DC, 1983.) [Pp. 171.] US$15.95.

Urban Transport in ASEAN. By V. Setty Pendakur. (Institute of Southeast Asian Studies — Research Notes and Discussions Papers Series No. 43, 1984.) [Pp. 65] $4.50 ISBN 9971–902–67–2.

The World Railway System. By Bernard de Fontgalland (Cambridge Univerisity Press, 1984.) [Pp. 209.] £16.00.     

Cost allocation by uniform traffic removal— Theoretical discussion and example highway cost applications

We propose four properties for equitable roadway cost allocations: (a) allocated costs should be based on full cost recovery, (b) allocated costs must be non-negative for any traveler group, (c) cost allocations should be additive, and (d) cost allocations should be consistent where equivalency factors among traffic categories exist. For cases with well-behaved cost functions, the uniform traffic removal technique discussed here uniquely satisfies these four properties and should be used whenever the four allocation properties are desired. Example applications as well as cases in which cost functions are not well behaved are discussed.     

Applications of Random-Utility-based Multi-region Input–Output Models of Transport and the Spatial Economy

Abstract

An introduction to random-utility-based multiregional input–output models used for the purpose of spatial economic and transport interaction modelling is provided. The main methodological developments and important results of a dozen applications from the years 1996–2013 are described. This is followed by an outlook of potential future directions. Further research is mainly needed in five areas: (a) overall validation of the method, perhaps through back-casting applications on infrastructure plans with observed trade impacts; (b) extensions of trade coefficient models to add realism and improve accuracy; (c) the use of multi-scale modelling to capture interdependencies between geographical scales and to improve the representation of exports and imports; (d) improvements in the representation of price effects, as well as innovation and technological progress, by way of variable technical coefficients; and (e) a deeper investigation of the algorithm used to include elastic selling prices.