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Fekih  Mariem  Bellemans  Tom  Smoreda  Zbigniew  Bonnel  Patrick  Furno  Angelo  Galland  Stéphane 《Transportation》2021,48(4):1671-1702
Transportation - Spatiotemporal data, and more specifically origin–destination matrices, are critical inputs to mobility studies for transportation planning and urban management purposes....  相似文献   
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Despite its rarity, Dinophysis acuminata is in terms of economic impact, the first toxic algal species along the coasts of Western Europe. It is observed at low levels (< 20 cell l− 1) all the year round but toxic events occur mainly in late spring and summer. D. acuminata ecophysiology is largely unknown due to the inability to culture it. Therefore, standard biomass models based on inorganic nutrition are largely inadequate. Presently, any progress in describing the conditions of population growth of this species will be a step forward to prediction of harmful events at the coast. This species has been observed at increased, albeit low cell densities in retentive eddies located in pycnocline layers. A concentration build-up of one species results from the balance between growth and loss processes, one of the latter being dispersal. The scales of interest for a D. acuminata population are of the order of 10 nautical miles on the horizontal and duration of 10 days, for a reported achievable growth rate of 0.6 day− 1. A three dimensional (3D) hydrodynamical model of the Bay of Biscay has been elaborated to reproduce hydrological structures over the last decade. We attempt here to relate the existence of retentive structures revealed from simulations under realistic forcing conditions and the toxic coastal events recorded in the 10-year time series of the French plankton monitoring network database. The eddies in the coastal area appear to be directly related with the Dinophysis coastal events and they may be a potential effective tool to predict those.  相似文献   
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During the February 1981 cruise FIBEX MD-25 between 30–50°E and 61–64°S, hydrography showed the presence of two gyres, confirmed by the geostrophic circulation relative to 1000 m from Levitus climatology, at the borders of these gyres concentrations of highly morphologically differentiated krill were found. Gaussian component analysis of krill samples, pooled by sectors, showed three cohorts of Euphausia superba in the western sector and one in the eastern sector. Across the sampling area, Thysanoessa macrura and E. superba occurred at separate stations. Analysis of cohorts in T. macrura separated two size groups in both the western and the eastern sectors. The use of a Differentiation Index (D.I.) [Färber-Lorda, J., 1990. Somatic length relationships and ontogenetic morphometric differentiation of Euphausia superba and Thysanoessa macrura of the southwest Indian Ocean during summer (February 1981). Deep-Sea Res. 37, 1135–1143.], based on somatic lengths, allows studying certain morphological differences within the populations sampled. Morphologically different and bigger males II (D.I. from 2.8 to 3.5) were present only in the southern transect while smaller males I (D.I. from 3.5 to 5.0) were present over the entire area. Biochemical composition of both species showed significant differences among stations for protein, lipids, and carbohydrates. A significant difference in lipid content was found between males I, and males II. For T. macrura, percentage of lipid content in mature animals was much higher than that in E. superba. The D.I. size distribution showed that when populations of E. superba were highly differentiated (corresponding to mature animals) in morphology, lipid content was high, and they were located near a gyre. Differences in morphometry can influence distribution of the species, because different developing stages have different swimming capacities. It is shown that, together with hydrography and trophic conditions, lipid content and morphometry of krill populations, are different but complementary aspects that help to understand krill ecology and distribution.  相似文献   
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每一个加工工艺的目标应该是在保持高生产率和低生产成本的同时,尽可能提高安全性和可预见性。为此,需要考虑以下几个因素:工件的材料、形状和尺寸、机床、CAM系统、工件和刀具的夹紧、切削刀具的选择及使用情况(见图1)。  相似文献   
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Demographic ageing is a key societal challenge in Europe as well as in many other western and non-western societies. A crucial dimension concerns elderly daily mobility patterns. While still partaking fewer and shorter trips than younger generations, today’s elderly have been found increasingly (auto)mobile. Although the elderly benefit from the independence, freedom of movement, and social inclusion, concerns may rise regarding the environmental and accessibility impacts of this induced mobility. The present study adds to the expanding literature on elderly mobility, an integrated analysis of the effects of socio-demographic, health, trip, spatial and weather attributes on elderly mobility. Utilizing travel diary data for Greater Rotterdam, The Netherlands, trip frequencies and transport mode choices of the elderly are analysed by means of zero-inflated negative binomial models as well as multinomial logit regression models, and contrasted to the non-elderly subpopulation to explore (dis)similarities. While the results show common determinants, the models also highlight important differences in the magnitude of the estimated coefficients and factors only influencing transport patterns for the elderly. Embedded in the context of an aging population, the empirical findings assist policy-makers and planners in several respects: For transportation plans and programs it is critical to recognize mobility needs of the elderly. As the seniors are becoming increasingly automobile, the results call for strategies to encourage older people to use more physically active and environmentally friendly transport modes such as public transport, walking and cycling.  相似文献   
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This study provides a large-scale micro-simulation of transportation patterns in a metropolitan area when relying on a system of shared autonomous vehicles (SAVs). The six-county region of Austin, Texas is used for its land development patterns, demographics, networks, and trip tables. The agent-based MATSim toolkit allows modelers to track individual travelers and individual vehicles, with great temporal and spatial detail. MATSim’s algorithms help improve individual travel plans (by changing tour and trip start times, destinations, modes, and routes). Here, the SAV mode requests were simulated through a stochastic process for four possible fare levels: $0.50, $0.75, $1, and $1.25 per trip-mile. These fares resulted in mode splits of 50.9, 12.9, 10.5, and 9.2% of the region’s person-trips, respectively. Mode choice results show longer-distance travelers preferring SAVs to private, human-driven vehicles (HVs)—thanks to the reduced burden of SAV travel (since one does not have to drive the vehicle). For travelers whose households do not own an HV, SAVs (rather than transit, walking and biking) appear preferable for trips under 10 miles, which is the majority of those travelers’ trip-making. It may be difficult for traditional transit services and operators to survive once SAVs become available in regions like Austin, where dedicated rail lines and bus lanes are few. Simulation of SAV fleet operations suggest that higher fare rates allow for greater vehicle replacement (ranging from 5.6 to 7.7 HVs per SAV, assuming that the average SAV serves 17–20 person-trips per day); when fares rise, travel demands shift away from longer trip distances. Empty vehicle miles traveled by the fleet of SAVs ranged from 7.8 to 14.2%, across the scenarios in this study. Implications of mobility and sustainability benefits of SAVs are also discussed in the paper.  相似文献   
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多形体筛查     
开发一种药物并将其推入市场并不是一件容易的事情,尤其是我们当前所处的环境是在西方的生产标准之下。法律环境和公众意念都对制造业有了很强烈的要求。很少有其它的行业,在被要求快速无误工作的同时,还要面对如此详细的审查和规章制度。那些因操作程序或设计不精确导致后期药物研发终止或临床试验冗余的公司,面临着艰巨的增加上市产品、树立和维持投资者信心的挑战。  相似文献   
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With the advent of electric vehicles with multiple motors, the steady-state and transient cornering responses can be designed and implemented through the continuous torque control of the individual wheels, i.e., torque-vectoring or direct yaw moment control. The literature includes several papers on sliding mode control theory for torque-vectoring, but the experimental investigation is so far limited. More importantly, to the knowledge of the authors, the experimental comparison of direct yaw moment control based on sliding modes and typical controllers used for stability control in production vehicles is missing. This paper aims to reduce this gap by presenting and analyzing an integral sliding mode controller for concurrent yaw rate and sideslip control. A new driving mode, the Enhanced Sport mode, is proposed, inducing sustained high values of sideslip angle, which can be limited to a specified threshold. The system is experimentally assessed on a four-wheel-drive electric vehicle. The performance of the integral sliding mode controller is compared with that of a linear quadratic regulator during step steer tests. The results show that the integral sliding mode controller significantly enhances the tracking performance and yaw damping compared to the more conventional linear quadratic regulator based on an augmented singletrack vehicle model formulation.  相似文献   
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