描述有效的原料药

尽管癌症治疗在过去的十多年取得了显著进展，但肿瘤学仍属于目前最不能满足临床需要的学科领域。在过去十多年里，临床药理学的进步和研发活动方面的巨大投资使得“癌症治疗”发展为“治疗过程研究”的数量急剧增加。但事实上，癌症和其他慢性疾病一样，治疗效果都很差，由此很多大型医药公司和生物制药公司都比以往更大力度的投入资金，用于肿瘤学和其他强效候选药物的研发上。[第一段]     

另类选择Acura MDX

田在美国全面改进了7座高级SUVAcuraMDX。第二代AcuraMDX配备最大输出功率为223kW（6000r／rain）的V型6缸发动机．以及可以带4轮驱动力控制的”SHAWD《SuperHandlingAll-WheeDrive）”。该车的发动机在美国市场是输出功率最高的自然吸气V6发动机。     

Towards comfort-optimal trajectory planning and control

ABSTRACT

This paper describes a method to analyse and evaluate different trajectory planning methods and controller types for usage in automated vehicles. Its application is shown by using a novel trajectory planning approach considering comfort aspects (based on Rapidly Exploring Random Tree (RRT)), two different controllers to follow the planned path (cascade controller and flatness based controller) and a simulation method to obtain resulting lateral vehicle accelerations. The method is used to plan and drive a trajectory through a roundabout. It can be seen that the lateral accelerations of the controller-driven vehicle are in the range of the values used for planning. However, the results of both controllers show differences in lateral deviation and in smoothness of lateral accelerations. The simulation results are then compared to real-world test drives in the same roundabout. The measured lateral accelerations are in the same range as well but show a smoother progression than the two controller models.     

Identification of potential sites for deep-ocean waste isolation with a geographic site-selection model

Identification of optimal sites for the isolation of waste on the abyssal seafloor was performed with two approaches: by the traditional method of map overlays of relevant attributes, and by a specially developed, automated Site-Selection Model (SSM). Five initial, Surrogate Sites, identified with the map-overlay approach, were then compared with the more rigorously produced scores from the SSM. The SSM, a process for optimization of site locations, accepts subjective, expert-based judgments and transforms them into a quantitative, reproducible, and documented product. The SSM is adaptable to any siting scenario. Forty-one factors relevant to the isolation scenario, including 21 weightable factors having a total of 123 scorable categories, have been entered into the SSM. Factors are grouped under project definition, unique environments, anthropogenic, geologic, biologic, weather, oceanographic and distance criteria. The factor scores are linked to a georeferenced database array of all factors, corresponding to 1°×1° latitude–longitude squares. The SSM includes a total of 2241 one-degree squares within 1000 n.m. of the U.S. coasts, including the western North Atlantic, the Gulf of Mexico, and the eastern North Pacific. Under a carefully weighted and scored scenario of isolation, the most favorable sites identified with the SSM are on the Hatteras and Nares Abyssal Plains in the Atlantic. High-scoring sites are also located in the Pacific abyssal hills province between the Murray and Molokai Fracture Zones. Acceptable 1° squares in the Gulf of Mexico are few and of lower quality, with the optimum location on the northern Sigsbee Abyssal Plain. Two of the five Surrogate Site locations, on the Hatteras and Sigsbee Abyssal Plains, correspond to the best SSM sites in each ocean area. Two Pacific and a second Atlantic Surrogate Site are located in low-scoring regions or excluded by the SSM. Site-selection results from the SSM, although robust, are an initial attempt to quantify the site-selection process. The SSM database exposes a significant lack of high-quality information for many areally mappable attributes on the abyssal seafloor, particularly bottom-current speed and measures of biologic productivity and flux. Terminologies and classifications of some measures, such as sediment types, suffer from parochialism and vary by ocean. Considerable research is needed even for a broad understanding of the environmental measures required to make sound societal decisions about use of the abyssal seafloor for disposal or other purposes.     

软件将是导航硬件商生存之本

2008年导航市场将进入洗牌阶段。随着许多国际大品牌GARMIN、TOMTOM等都纷纷进入中国市场瓜分导航市场的这块蛋糕，中国的中、小品牌生存空间将受到挤压，甚至，许多小品牌在今年或明年将有可能会消失。那么，怎么才能继续生存并有比较好的前景呢？     

严峻问题

今年关于太平洋航线有两个不确定因素,即美国进口量增长将会大大放缓,同时美国出口量会继续增加.因此,几乎所有其他的问题都是不确定的:进口量是否会增长还是会减少?     

Evaluation of factors for carrier selection in the China Pearl River delta

The efficient integration of logistics modes is critical for international cargo shipping. The local transportation connecting to the export port then plays a vital role in such integration. This paper investigates the problems of carrier selection in the China Pearl River delta area, with respect to international shipping. The analytical hierarchy process (AHP) model is constructed based on a comprehensive industrial interviews and statistical analysis. Rather than simply ranking the given alternatives, we use AHP is used to analyse the weakness and strength of impacting factors in carrier selection. The model is implemented under different types of shipper. Seven criteria are statistically summarized from the questionnaire for evaluating eight different modes. The results are useful to those liner companies serving the PRD region in relationship to port selection and fleet deployment.