Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10

Objective To map a mouse deafness gene.identify the underlying mutation and develop a mouse model for human deafncss.Methods Genetic lindage cross and genome scan wer used to map a novel mutation named hypoplasia of the membranous labyrinth (hml),which causes hearing loss in mutant mice.Results ① hml was mapped on mouse Chr 10 (～43 cM from the centromere) suggests that the homologous human gene is on 12q22--q24, which was defined on the basis of known mouse-human homologies (OMIM,2004). ② This study has generated 25 polymorphic microsateUite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500 kb area.     

Estimation of Load-Induced Damage and Repair Cost in Post-Tensioned Concrete Rocking Walls

Post-tensioned concrete rocking walls might be used to avoid severe seismic damage at the base of structural walls, decrease residual drift, and lessen post-earthquake repair costs. The prediction of load-induced damage to the rocking wall resulting from seismic loading can provide an extremely valuable tool to evaluate the status and safety of structural concrete walls following earthquakes. In this study, the behavior and the damage state of monolithic, self-centering, rocking walls, as a new type of concrete rocking wall, are investigated. The nonlinear mechanical behavior of the wall is first modeled numerically, and subsequently the mechanical parameters from the numerical simulation are used to generate the local damage index. The results from the damage index model are compared with the full-scale test results, confirming the viability of the numerically based damage index method for estimating the seismically induced damage in concrete walls. Moreover, the estimated damage can be utilized as a qualitative and quantitative scale to assess the status of the wall following seismic loading events. Finally, an equation is proposed to estimate the repair cost based on the predicted damage state for the studied structural system.     

A Practice-Based Coupling of the Precautionary Principle to the Large Marine Ecosystem Fisheries Management Concept with a Policy Orientation: The Northeast United States Continental Shelf as a Case Example

This article addresses interdisciplinary sustainable aspects of fisheries as part of ocean management. Human-caused impacts and their role as modifiers of living marine resources is discussed. The research note also theorizes about contemporary global change and its prospective biological consequences, especially when coupled with human-induced factors in coastal marine waters. Also addressed is the management and ecological aspects of fish stock populations as part of a large marine ecosystem (LME) in the Northeast United States continental shelf of the Atlantic Ocean with suggestions for an interdisciplinary policy orientation paradigm to foster the sustainability of marine life in the sea.     

EFD and CFD for KCS heaving and pitching in regular head waves

The KCS container ship was investigated in calm water and regular head seas by means of EFD and CFD. The experimental study was conducted in FORCE Technology’s towing tank in Denmark, and the CFD study was conducted using the URANS codes CFDSHIP-IOWA and Star-CCM+ plus the potential theory code AEGIR. Three speeds were covered and the wave conditions were chosen in order to study the ship’s response in waves under resonance and maximum exciting conditions. In the experiment, the heave and pitch motions and the resistance were measured together with wave elevation of the incoming wave. The model test was designed and conducted in order to enable UA assessment of the measured data. The results show that the ship responds strongly when the resonance and maximum exciting conditions are met. With respect to experimental uncertainty, the level for calm water is comparable to PMM uncertainties for maneuvering testing while the level is higher in waves. Concerning the CFD results, the computation shows a very complex and time-varying flow pattern. For the integral quantities, a comparison between EFD and CFD shows that the computed motions and resistance in calm water is in fair agreement with the measurement. In waves, the motions are still in fair agreement with measured data, but larger differences are observed for the resistance. The mean resistance is reasonable, but the first order amplitude of the resistance time history is underpredicted by CFD. Finally, it seems that the URANS codes are in closer agreement with the measurements compared to the potential theory.     

A new efficient EDI system for container cargo logistics

There have been many efforts to develop a logistics information system in the Korean logistics industry. In spite of these efforts, there are many points which need improvement in the Logistics Information System, of which function is the electronic data communication without added value. This paper aims to describe some of the main problems and the successful factors which are being found in the evolution of the present EDI systems for clearing import/export container cargoes, with special reference to Singapore, Korea, and Japan. Following this, leaving legal issues aside, to suggest workable guidelines for designing a new efficient EDI system for container cargo logistics. As a result of the review, the following successful factors are drawn: (a) the planning, requirement analysis and design of EDI are critical, as it provides a framework for its implementation; (b) as the data of customs clearance are an integral part of a logistics EDI system, the inclusion of customs in the system design is essential; (c) the sharing system of cargo data as the framework of the logistics EDI is efficient for data interchange; (d) the EDI software for the user has been developed and provided by an EDI network operating company; and (e) to facilitate communication between trading partners and the transport sector, it is necessary to adopt a global message standard, such as EDIFACT.     

Overview of intelligent ship route optimization methods北大核心CSCD

智能船舶航线优化在学术界和工业界均受到越来越多的关注。针对智能船舶航线优化问题,从航线设计方法和航线优化算法这2个层面,分别阐述各种设计方法和优化算法的特点。结合近5年来的最新研究成果,在分析国内外智能船舶航线优化技术发展现状的基础上,将航线设计方法归纳为3种,即基于气象数据的航线优化、基于油耗模型的航线优化以及基于航线库或航路点库的航线优化,剖析其技术内涵及应用情况;深入分析改进的等时线法、动态规划法、图形搜索算法、智能算法、人工智能和机器学习算法的特性及不足,总结归纳将各类算法应用于智能船舶航线优化时存在的主要问题。最后,简要展望智能船舶航线优化的发展趋势,为未来在该领域的研究提供一定的思路。     

Quantifying uncertainty in high-resolution coupled hydrodynamic-ecosystem models

Marine ecosystem models are becoming increasingly complex and sophisticated, and are being used to estimate the effects of future changes in the earth system with a view to informing important policy decisions. Despite their potential importance, far too little attention has been, and is generally, paid to model errors and the extent to which model outputs actually relate to real-world processes. With the increasing complexity of the models themselves comes an increasing complexity among model results. If we are to develop useful modelling tools for the marine environment we need to be able to understand and quantify the uncertainties inherent in the simulations. Analysing errors within highly multivariate model outputs, and relating them to even more complex and multivariate observational data, are not trivial tasks. Here we describe the application of a series of techniques, including a 2-stage self-organising map (SOM), non-parametric multivariate analysis, and error statistics, to a complex spatio-temporal model run for the period 1988–1989 in the Southern North Sea, coinciding with the North Sea Project which collected a wealth of observational data. We use model output, large spatio-temporally resolved data sets and a combination of methodologies (SOM, MDS, uncertainty metrics) to simplify the problem and to provide tractable information on model performance. The use of a SOM as a clustering tool allows us to simplify the dimensions of the problem while the use of MDS on independent data grouped according to the SOM classification allows us to validate the SOM. The combination of classification and uncertainty metrics allows us to pinpoint the variables and associated processes which require attention in each region. We recommend the use of this combination of techniques for simplifying complex comparisons of model outputs with real data, and analysis of error distributions.     

Large oil tankers and the Baltic marine environment: A statistical survey

The short Baltic export route for Russian oil is an attractive source of supply for the European energy market. The article examines the Russian oil export trade in the Baltic based on Automatic Identification System (AIS) data from 2005 matched with supplementary data. The first part of the article gives a survey of activities and characteristics of 261 large crude oil tankers, their flag states and owner countries. The second part views the data in the context of accidental oil spill risk. Greek and Russian owners are leading carriers in this trade. Russia plays a double leading role as oil exporter and shipowning country, securing major cargo shares for nationally owned vessels, while also giving a preferential spot in the trade to Greek owners. Where environmental aspects are concerned, previous research has linked vessel characteristics with the risk of casualty. Knowledge of flag, age, ownership and activity levels adds useful information about environmental risk. The data show that flags associated with very high casualty or detention probabilities were represented by 18% of the activity in this trade. Older vessels have a similar share, and at this particular time probably represent the more serious threat of accidental oil spills.     

Assessment of diesel combustion noise overall level in transient operation

Combustion noise in passenger cars powered with direct injection (DI) diesel engines is frequently the main reason why end-users are reluctant to drive this type of vehicle. Thus, the great potential of diesel engines for environment preservation — due to their lower CO₂ emissions — could be missed. This situation worsens with the current design trends (engine downsizing) and the emerging new diesel combustion concepts (Homogeneous Charge Compression Ignition-HCCI, Premixed Charge Compression Ignition-PCCI, etc.), which are intrinsically noisy. This negative feature can be even more critical in transient operation due to the contribution of the temporal changes of both source and transmission path on engine noise. Therefore, combustion noise must be considered as an additional essential factor in engine development, together with performance, emissions and driveability. Thus, suitable evaluation procedures that can be integrated into the global engine development process in a timely and cost-effective manner are imperative. Regarding the evaluation procedures, most of the work available in the literature addressed combustion noise at steady operation. To surpass this limitation, two possible approaches — adapted from the classical and multiple regression methods — for the overall level assessment of combustion noise in transient conditions are evaluated in this paper.