白术挥发油治疗癌性恶病质的实验研究

目的研究白术挥发油治疗癌性恶病质的效果并探讨其可能机制。方法通过C57BL6小鼠接种Lewis(小鼠肺腺癌)建立癌性恶病质动物模型。实验动物分5组:模型对照组、正常对照组、白术水煎剂组(DA)、白术挥发油组(VOA)、康莱特组(KLT)。观察癌性恶病质鼠治疗后的生理状况(体重、摄食量等)并采用RIA检测血清TNF-α及IL-6水平。结果①各治疗组小鼠生理状况明显改善、摄食量增加,体重增加仅见于KLT组,但均未恢复到正常水平。②VOA组与DA组小鼠血清TNF-α、IL-6水平均较模型组明显降低,VOA优于DA组。KLT虽然能使TNF-α水平降低,但却明显提高了IL-6水平。结论白术挥发油具有明显的抗癌性恶病质的作用,其机制可能与其能抑制肿瘤生长、调节血清细胞因子TNF-α、IL-6的异常升高有关。     

大鼠脊髓损伤后MAP-2的表达及与运动功能恢复的相关性

目的研究大鼠脊髓损伤后MAP-2表达的变化及与运动功能恢复的相关性。方法健康成年Wistar大鼠36只,随机取6只作为正常对照组,余30只制作成脊髓打击伤动物模型,随机分为5组,每组6只。伤后1、3、7、14、28d取材,应用免疫组织化学方法观察MAP-2的表达,采用计算机图像分析系统,进行定量分析;用改良的Tarlov评分、斜板试验观察大鼠脊髓损伤后运动功能的恢复情况及MAP-2的表达和二者的相关程度。结果大鼠脊髓损伤后MAP-2的表达在损伤后1-14d呈进行性升高,并在损伤后14d达到高峰,损伤后28d较损伤后14d明显下降(P<0.01),但仍明显高于正常对照组(P<0.01),呈高水平表达;大鼠脊髓损伤后1-28d改良的Tarlov评分、斜板试验进行性升高,并在损伤后28d达到高峰,但仍明显低于正常对照组(P<0.01)。MAP-2的表达和改良的Tarlov评分、斜板试验在损伤后呈正相关(|r1|=0.81,P<0.01;|r2|=0.79,P<0.01)。结论大鼠脊髓损伤后MAP-2的表达和运动功能的恢复呈正相关,MAP-2很可能参与了大鼠脊髓损伤后运动功能的恢复。     

单索面宽幅矮塔斜拉桥拉索作用下主梁剪力滞效应分析

矮塔斜拉桥主梁一般采用箱型截面形式,它不仅受轴向压力,还要承担相当部分的弯矩和剪力,所以其受力复杂,空间应力的不均匀现象十分严重.并且随着箱梁的宽度的增大剪力滞效应更加严重.文中以西江特大桥为研究背景,采用有限元理论,通过建立拉索锚固区梁段空间有限元模型,研究分析宽幅主梁在成桥阶段的受力特性和剪力滞效应,以及在索力纵向力作用下桥面正应力分布情况和传递角度.结果表明该桥的主梁受力合理,剪力滞效应不明显.索力的纵向分力在宽幅箱梁中的传递角度为39.3°,该桥的设置后浇带的施工方法满足主梁的受力特性要求.     

京通快速路公交专用车道建设效果评估

为评估京通快速路公交专用车道的建设效果,在介绍公交专用车道建设背景与方案的基础上,对比分析了公交专用车道开通前后京通快速路及其周边路网的交通运行状况,并对乘客满意度进行了调查。评估结果显示,京通快速路公交专用车道开通后,交通走廊的公交吸引力明显增强,早高峰公交专用车道内公交运行速度超过50 km.h-1,公交客流量增长0.8万人次,整体交通运行效率和道路资源利用率有所提升,保障了大多数居民的出行利益。     

城市交通组织优化实践——以太原市为例

交通组织优化是城市交通管理的重要技术手段.为研究交通供给策略与交通需求管理在城市交通组织优化中的指导作用,对交通供给策略、交通需求管理和交通组织优化的概念进行解析.然后,结合交通供给策略与交通需求管理在太原市城市交通组织优化过程中的应用,对比分析增加交通供给与控制交通需求前后的道路交通量变化及交通组织优化效果.最后指出...     

浅埋偏压、冲沟地质条件下公路隧道进洞方案研究

由于山区地形复杂多变,线路展线困难,洞口浅埋偏压、冲沟、降水等不利因素制约着高速公路隧道进洞施工。隧道进洞施工安全和洞口稳定是隧道安全施工的有利保障。结合株岭隧道右线进口工程现场地质条件,研究制定了明挖暗进和盖挖施工相结合的施工方案,确保了隧道安全施工。     

电动汽车电液并行制动系统研究

在对传统汽车液压制动系统进行适当改造的基础上,提出了一种适合于电动汽车使用的电液并行制动系统结构,并设计了相应的并行制动力分配方案.鉴于施加再生制动力引起制动稳定性的变化,通过整车的仿真分析,提出了系统改进的技术方案.最后用台架试验对系统的可行性和有效性进行验证.     

Knock in dual-fuel diesel combustion with an E85 ethanol/gasoline blend by multi-dimensional simulation

In this paper, knocking combustion in dual-fuel diesel engine is modeled and investigated using the CFD code coupled with detailed chemical kinetics. The ethanol/gasoline blend E85 is used as the primary fuel in a dual-fuel combustion concept based on a light-duty diesel engine equipped with a common-rail injection system. The E85 blend is injected and well mixed with intake air in the intake manifold and is ignited by the direct injection diesel fuel. A 46-species, 187-reaction Multicomponent mechanism is adopted to model the auto-ignition process of the E85/air/diesel mixture ahead of the flame front. Based on the model validation, knocking combustion under boost and full load operating condition for 0 %, 20 %, 50 %, as well as 70 % E85 substitute energy is simulated. The effects of E85 substitute rate and two stage injection strategies on knock intensity, power output, as well as location of the auto-ignition initiation is clearly reproduced by the model. The calculation result shows that, for a high E85 rate of 50 % and 70 % with single injection strategies, the most serious knock and the origin of auto-ignition always occurs far away from where the flame of diesel spray is first generated, at the center of combustion chamber, due to higher pressure wave, relatively richer E85 mixture and longer distances of flame propagation. The two stage injection strategies with a small amount of diesel pilot injection ahead of the main injection primarily influence the ignition behavior of the directly injected fuel, leads to a lower pressure rise rate and a reduced propagation distance, both of which contribute to the attenuation of knock intensity for a higher E85 rate.     

Lateral stability control of dynamic steering for dual motor drive high speed tracked vehicle

In this paper, the torque and power required by dual motors for electric tracked vehicle during dynamic steering maneuvers with different steering radiuses are analyzed. A steering coupling drive system composed of a new type of center steering motor, two Electromagnetic (EM) clutches, two planetary gear couplers, and two propulsion motors is proposed for the dual motors drive high speed electric tracked vehicle (2MHETV), which aims to improve its lateral stability. An average torque direct distribution control strategy based on steering coupling and an optimization-distribution-based close-loop control strategy are designed separately to control the driving torque or regenerative braking torque of two propulsion motors for vehicle stability enhancement. Then models of the 2MHETV and the proposed control strategy are established in Recudyn and Matlab/Simulink respectively to evaluate the lateral stability of dynamic steering for the 2MHETV with different steering radiuses on hard pavement.The simulation results show that the lateral stability of the 2MHETV can be significantly improved by the proposed optimization-distribution-based close-loop control strategy based on steering coupling system.     

四路信号控制交叉口交通事故预测模型研究

通过对北京郊区四路信号控制交叉口进行实地调查,在获取事故数据及道路几何要素、环境要素、交通流要素等大量数据的基础上,利用相关性分析寻找出与交通事故相关性显著的影响因素,并采用AIC原则分析法确定模型形式,分别建立了四路信号控制交叉口死亡人数、受伤人数、事故次数预测模型。模型的建立有助于对交叉口进行安全分析诊断及预测交叉口的交通事故发生规律。