LEISHMANIA PROMASTIGOTES EVADE INTERLEUKIN 12 INDUCTION BY MACROPHAGES AND STIMULATE A BROAD RANGE OF CYTOKINES FROM CD_（4）~（＋

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用动物模型定位、克隆复杂性疾病的易感基因:以类风湿关节炎动物模型为范例(续前)

3在大鼠关节炎模型上定位克隆易感基因在大鼠关节炎模型定位克隆易感基因,如图1所示:是将经典的纯系育种分离技术,结合congenic和重组系的建立,窄化易感区域,定位克隆基因,最终确定基因变异、功能变化和关节炎表型的关系[34-35]。具体步骤见图1。图1在大鼠关节炎模型上,定位克隆关节炎易感基因流程图Fig.1 Identification of susceptible genes to arthritis in rat models3.1选择亲代近交系,建立关节炎模型在数种关节炎模型中,用于进行基因定位克隆的模型有:胶原诱导性关节炎、油诱导性关节炎和Pristane诱导的关节炎。我们的研究工作主要…     

Numerical analysis of the dynamic interaction between wheel set and turnout crossing using the explicit finite element method

A three-dimensional (3-D) explicit dynamic finite element (FE) model is developed to simulate the impact of the wheel on the crossing nose. The model consists of a wheel set moving over the turnout crossing. Realistic wheel, wing rail and crossing geometries have been used in the model. Using this model the dynamic responses of the system such as the contact forces between the wheel and the crossing, crossing nose displacements and accelerations, stresses in rail material as well as in sleepers and ballast can be obtained. Detailed analysis of the wheel set and crossing interaction using the local contact stress state in the rail is possible as well, which provides a good basis for prediction of the long-term behaviour of the crossing (fatigue analysis). In order to tune and validate the FE model field measurements conducted on several turnouts in the railway network in the Netherlands are used here. The parametric study including variations of the crossing nose geometries performed here demonstrates the capabilities of the developed model. The results of the validation and parametric study are presented and discussed.     

One-dimensional model on fuel penetration in diesel sprays with gas flow

In diesel engine, spray penetration is usually changed by in-cylinder gas flow. Accurate prediction on diesel spray with gas flow is important to the optimal design of diesel fuel injection system. This paper presents a theory investigation focusing on the penetration of diesel spray with gas flow. In order to understand the effect of gas flow on the penetration of diesel spray, a one-dimensional spray model is developed from an idealized diesel spray, which is able to predict the spray behavior under different gas flow conditions. The ambient gas flow is simplified as ideal flow that has only constant flow velocity along x-axial and y-axial directions of spray. The x-axial and y-axial directions are respectively defined as along and vertical spray directions. The main assumption is that the y-axial direction gas flow has no effect on the penetration of spray along x-axial direction. The principles of conservation of mass and momentum are used in the derivation. Momentum of in-cylinder air flow is also taken into consideration. Validation of the model at stable condition is achieved by comparing model predictions with experimental measurements of diesel spray without gas flow from Naber's experiments. Furthermore, CFD simulations on penetration of diesel spray with gas flow were performed with the commercial code AVL-fire. The onedimensional model is validated by the penetration results with gas flow from CFD calculation. Results show that a reasonable estimation of the spray evolution can be obtained for both with and without ambient gas flow conditions.     

Estimation of maximum road friction coefficient based on Lyapunov method

With the real time and accurate information of motor torque and rotation speed of the four-in-wheel-motordrive electric vehicles, a slip based algorithm for estimating maximum road friction coefficient is designed using Lyapunov stability theory. Modified Burckhardt tire model is used to describe longitudinal slip property of the tire. By introducing a new state variable, a nonlinear estimator is proposed to estimate the longitudinal tire force and the maximum road friction coefficient simultaneously. With the appropriate selection of estimation gain, the convergence of the estimation error of the tire longitudinal force and maximum road friction coefficient is proved through Lyapunov stability analysis. In addition, the error is exponentially stable near the origin. Finally the method is validated with Carsim-Simulink co-simulation and real vehicle tests under multi working conditions in acceleration situation which demonstrate high computational efficiency and accuracy of this method.     

基于神经网络的高温下（后）预应力损失分析

提出了基于神经网络的高温下(后)预应力损失的评价方法.针对影响高温下(后)预应力损失的复杂多变性和相当强的不确定性,建立了基于神经网络的高温下(后)预应力损失模型.运用神经网络强大的自适应、自组织、自学习的能力以及高度的非线性映射性、泛化性和容错性的特点,通过对训练样本的神经网络学习,建立了预应力损失与温度、初始有效预应力以及高温条件的网络关系,最终实现了对测试样本的预应力损失预报.     

A fundamental investigation of tilt control systems for narrow commuter vehicles

One way of addressing traffic congestion is by efficiently utilizing the existing highway infrastructure. Narrow tilting vehicles that need a reduced width lane can be part of the solution if they can be designed to be safe, stable, and easy to operate. In this paper, a control system that stabilizes the tilt mode of such a vehicle without affecting the handling of the vehicle is proposed. This control system is a combination of two different types of control schemes known as steering tilt control (STC) and direct tilt control (DTC) systems. First, different existing variations of both STC and DTC systems are considered and their shortcomings analysed. Modified control schemes are then suggested to overcome the deficiencies. Then a new method of integrating these two control schemes that guarantees smooth switchover between the controllers as a function of vehicle velocity is proposed. The performance of the proposed STC, DTC, and integrated systems is evaluated by carrying out simulations for different operating conditions and some experimental work. The design of a second-generation narrow tilting vehicle on which the developed control system has been implemented is presented.     

基于图论的列车运行径路分析与构造

采用图论及系统结构的分析方法,提出列车运行径路的表达、组织方法和列车运行径路的构造原理,方法。从而效清晰全面地表面路局列车运行径路,并使数据冗余尽可能的少。     

论研究与开发费用的会计处理

本文对企业研究与开发费用的现行会计处理方法,即全部费用化和部分资本化作了分析,并指出了这两种处理方法存在的缺点。提出了在知识经济时代,随着企业研究开发费用投入的不断增加,对研究开发费用的会计处理应采用全部资本化处理方法的观点。