T2DM患者外周血单个核细胞中NF-κB的表达变化及其相关因素的探讨

目的探讨无并发症的2型糖尿病(T2DM)患者外周血单个核细胞(PBMC)中核因子-κB/p65(NF-κB/p65)、核因子-κB抑制蛋白α(IκB-α)表达水平的变化及其与氧化应激、糖代谢等因素的关系。方法以无并发症T2DM患者30例、非糖尿病对照(NDM)30例为研究对象,测定其PBMC中NF-κB/p65、IκB-α蛋白表达水平,血清丙二醛(MDA)、超氧化物歧化酶(SOD)及糖化血红蛋白(GHb)等指标变化。结果与NDM组相比,T2DM患者NF-κB/p65表达升高;MDA水平升高,SOD活性降低。NF-κB/p65表达与MDA、GHb、稳态模型胰岛素抵抗指数呈正相关,与SOD呈负相关。T2DM患者与NDM间IκB-α蛋白表达无统计学差异。结论无并发症的T2DM患者PBMC中NF-κB/p65表达升高,其表达水平与氧化应激、血糖控制水平相关。     

U.S. import/export container flow modeling and disruption analysis

International containerized freight movement is a vital part of the supply chain for many companies, and a critical element of moving consumer goods to points of retail sale within the U.S. Containerized imports also present a clear security concern (e.g., terrorists attempting to ship “dirty bombs,” chemical, biological or even nuclear weapons, into the U.S. in a shipping container). The goal of the research presented here is to create a modeling tool for analyzing flows of U.S. imports and exports of containerized freight, and the potential changes in those flows under a variety of conditions (e.g., port disruptions, extensive security-related delays, etc.). Our focus is on movements through maritime container ports, and not overland movements between the U.S. and Canada or Mexico.The network model, referred to as the System for Import/Export Routing and Recovery Analysis (SIERRA), represents container movements between the U.S. and 46 other countries that account for the vast majority of U.S. imports and exports. The SIERRA model is a network equilibrium model that predicts flows between foreign countries and North American ports, the total volumes handled (import and export) by each port, the modal volumes (truck and rail) moving domestically into and out of each port, and volumes between each port and a set of transportation analysis zones within the U.S.     

水面舰艇基本通信能力的效能评估

水面舰艇的基本通信能力是舰艇通信系统效能的重要方面,根据通信设备的工作特性,对舰艇的基本通信能力按业务类型分类,并运用层次分析法的思想构建了指标体系,对水面舰艇的基本通信能力进行效能评估.结果证明了该方法的可行性,此方法也可为下一步系统通信效能分析提供参考.     

Correcting for endogeneity in behavioral choice models with social influence variables

While psychologists and behavioral economists emphasize the importance of social influences, an outstanding issue is how to capture such influences in behavioral models used to inform urban planning and policy. In this paper we focus on operational models that do not require explicit knowledge of the individual networks of decision makers. We employ a field effect variable to capture social influences, which is calculated as the percent of population in the peer group that has chosen the specific alternative. We define the peer group based on socio-economic status and spatial proximity of residential location. As in behavioral economics and psychology, the concept is that one is influenced by the choices made by one’s peers. However, using such a social influence variable in a behavioral model causes complications because it is likely endogenous; unobserved factors that impact the peer group also influence the decision maker, yielding correlation between the field effect variable and the error. The contribution of this paper is the use of the Berry, Levinsohn, and Pakes (BLP) method to correct the endogeneity in a choice model. The two-stage BLP introduces constants for each peer group to remove the endogeneity from the choice model (where it is difficult to deal with) and insert it into a linear regression model (where endogeneity is relatively easier to deal with). We test the method using a mode choice data set from the Netherlands and readily available software and find there is an upward bias of the field effect parameter when endogeneity is not corrected. The procedure outlined presents a practical and tractable method for incorporating social influences in choice models.     

层间水对水下双层结构撞击历程的影响分析

双层壳体结构是潜艇等大型水下结构的重要结构形式,潜艇结构的水下碰撞是潜艇的主要事故形式,然而,针对双层壳体的潜艇结构水下碰撞问题的研究工作目前却极为有限.文中首先提出潜艇碰撞问题,并对其碰撞特征进行分析,然后针对潜艇水下碰撞环境下,层间水对碰撞历程的影响和双层结构的碰撞特点进行了理论分析,在数值仿真计算的基础上,着重讨论了双层板结构在碰撞过程中,层间水对撞击速度、碰撞力以及双层板吸能特性的影响,分析结果显示,层间水对双层壳板撞击历程的影响主要体现在两方面:一是接触初始阶段,耐压壳板将由于层间水的存在,与非耐压壳板组成抗冲击弹簧体系参与抗冲击作用,吸收冲击能量,这对于双层壳板的防撞性能是有利的;二是非耐压壳板穿透后,层间水的影响主要体现为水对耐压壳板的粘附作用,耐压壳板的抗撞能力显著下降.     

平台支撑的潜艇内部平面舱壁极限强度的模型试验研究

为了研究平台支撑的潜艇内部平面舱壁极限强度,根据实艇舱壁结构,按1∶2的缩尺比设计制作了一个舱壁模型,采用内压试验方法进行了模型极限承载能力的试验.利用国际通用的大型非线性有限元分析软件MSC/MARC,对舱壁模型进行了几何/材料的双重非线性的有限元分析,试验值与有限元分析计算值吻合良好.通过对模型试验结果的分析,得出了一些对指导潜艇平面舱壁结构设计有实用价值的结论.     

海上沉船碍航概率风险评估

为对我国沿海水域沉船进行科学的风险评估及处置决策,确保通航船舶水上安全和畅通,基于事件树方法分析了通航船舶碰撞沉船事故的发生过程和机理,建立了沉船碍航概率风险评估模型.假定通航船舶在航路中的航迹线服从正态分布,根据沉船位置确定了通航船舶驶入碰撞航路的几何概率.根据国内外事故资料确定通航船舶发生异常而避碰失败的基准偏航概率,并考虑了风、流、能见度和交通密度等因素进行修正.通过对实际沉船碍航特性的评估,验证了该方法对沉船管理和处置决策具有实用性和可操作性.     

符汶大桥体外预应力加固技术研究

"5.12"地震后四川地区大量桥梁受到不同程度破坏,以符汶大桥的体外预应力筋张拉加固为例,分析了体外预应力加固理论、施工技术,同时总结出体外预应力加固技术在施工中的关键要点,为今后类似桥梁加固提供参考。     

Analysis of impact damage characteristics of marine carbon fiber composite laminates embedded with PEI film北大核心CSCD

[目的]在传统船用碳纤维复合材料层合板层间添加热塑性相材料能有效提升船用复合材料的抗冲击性能,为探究其冲击损伤特性,开展实验研究。[方法]使用光学显微镜观察层合板的热塑性/热固性界面,分析两相材料的结合方式;对不同结构的复合材料层合板进行低、中、高3种不同能量的低速冲击;通过超声C扫描与电子显微镜,对各试件的损伤形貌进行观测,以研究各试件的冲击响应及损伤机理。[结果]结果显示,相较于碳纤维层合板,含热塑性相的船用复合材料层合板具有更好的损伤阻抗;内部嵌膜层合板试件在冲击能量为8和12 J的冲击下,内部分层损伤分别减少了19%和39%,且受到12 J冲击后,内部结构损伤较小,完整性较好。[结论]将PEI热塑性膜嵌于内部能提升层合板的韧性,显著减少内部分层损伤,明显提升内部嵌膜层合板的抗冲击性能。     

Bandgap optimization for chiral acoustic metamaterials based on material selection method北大核心CSCD

［Objectives］This study seeks to expand the bandgap frequency band, reduce the bandgap starting frequency and analyze and optimize the bandgap parameters of acoustic metamaterials. ［Methods］The influence of geometrical and material parameters on the bandgap properties of acoustic metamaterials is analyzed, and a method for maximizing the bandgap width is proposed. The multi-objective optimization problem is converted into a single objective optimization problem by normalizing the bandgap frequency coefficients. Structural material conversion is achieved via the material selection optimization method, and the optimization equations of bandgap parameters are established on the basis of weight-lightening. For chiral acoustic metamaterials, the material properties (density and wave velocity) and geometric parameters (scatterer diameter, ligament thickness and coating thickness) are defined as design variables, and the comprehensive optimization of structural parameters and material selection of acoustic metamaterials based on weight-lightening are implemented. ［Results］The optimization results show that the bandgap width increases by 27.7% and the lower bound frequency decreases by 1048 Hz, thereby achieving the goal of expanding the bandgap width based on lightweight acoustic metamaterials. The acoustic transmission analysis of the finite chiral acoustic metamaterial structure is then carried out to verify the effectiveness of the proposed method. ［Conclusions］The results show that the goal of lightweight acoustic metamaterials can be effectively achieved by integrating the comprehensive optimization of structural parameters and materials. As such, this study provides references for the design of new-type acoustic metamaterials. © 2023 Authors. All rights reserved.