AQP4在COPD支气管黏膜的表达及其与患者肺功能、气道黏膜炎症的相关性

目的通过免疫组化法检测支气管黏膜中水通道蛋白-4(aquaporin-4,AQP4)的表达,观察正常组和慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)组支气管黏膜中AQP4表达与气道黏膜炎症及肺功能的关系,明确AQP4在COPD发生、发展中的作用,为COPD的防治开辟新途径。方法选择正常人和COPD患者各30例,测试肺功能,并行支气管镜检查,取得支气管黏膜标本,用免疫组化法检测AQP4表达,HE染色观察支气管黏膜炎症细胞浸润程度。结果COPD组较对照组AQP4表达减弱有极显著差异(P<0.001)。AQP4表达和FEV1/FVC、FEV1/pred%呈正相关(P<0.001),与支气管黏膜炎症严重程度呈负相关(P<0.001)。结论COPD患者AQP4表达减少可能是其肺功能下降及气道炎症加重的原因之一。临床上可以通过改善AQP4治疗COPD。     

QoS awared power and admission controls based on non-cooperative game theory in wireless networks

In order to better accommodate heterogeneous quality of service (QoS) in wireless networks, an algorithm called QeS-aware power and admission controls (QAPAC) is proposed. The system is modeled as u non- cooperative game where the users adjust their transmit powers to maximize the utility, thus restraining the interferences. By using adaptive utility functions and tunable pricing parameters according to QoS levels, this algorithm can well meet different QoS reqniremcnts and improve system capacity compared with those that ignore the QoS differ- ences.     

浅谈九曲小净距隧道的施工

小净距隧道由于隧道净距小．施工时双洞相互影响较大,对隧道围岩特别是中夹岩岩体稳定性有很大的影响。因此,探讨安全、合理、经济的高速公路小净距隧道施工方法十分必要。以九曲小净距隧道为例．介绍小净距隧道的超前支护、洞身开挖、中央岩柱加固、锚喷支护、监控量测等关键工序的施工方法和技术要点。     

A total generalized optimal velocity model and its numerical tests

A car-following model named total generalized optimal velocity model （TGOVM） was developed with a consideration of an arbitrary number of preceding vehicles before current one based on analyzing the previous models such as optimal velocity model （OVM）, generalized OVM （GOVM） and improved GOVM （IGOVM）. This model describes the physical phenomena of traffic flow more exactly and realistically than previous models. Also the performance of this model was checked out by simulating the acceleration and deceleration process for a small delay time. On a single circular lane, the evolution of the traffic congestion was studied for a different number of headways and relative velocities of the preceding vehicles being taken into account. The simulation results show that TGOVM is reasonable and correct.     

胆囊切除术后患者十二指肠胃反流的研究

目的　观察胆囊切除术后综合征 (postcholecystectomysyndrome,PCS)患者十二指肠胃反流 (duodenogastricre flux ,DGR)的变化 ,探讨胆囊切除后DGR发生情况及其与PCS的关系。方法　 2 0例胆囊切除术后综合征患者行动态 2 4h胃内pH和胆红素 (Bilitec 2 0 0 0 )检测 ,并与 10例胆石症患者和 15例正常对照者作比较。结果　胆囊切除术后综合征组与正常对照组比较 ,碱反流和胆汁反流均不增加。胆石症组碱反流较对照组增加 ,胆汁反流不增加。结论　胆囊切除术后综合征患者十二指肠胃反流并不增加     

原位肝移植术围术期生化变化及麻醉管理

目的　探讨原位肝移植手术的麻醉管理及其代谢指标的变化。方法　择期肝移植患者 11例 ,对其无肝前期 6 0min、无肝期 2 0min、4 0min、新肝灌流恢复期 2 0min、4 0min所采血样行血气 (pH、BE、HCO3 -)、电解质 (K + 、Ca2 + )、血糖、凝血三项 (PT、FIB、APTT)检测。结果　与无肝前期 6 0min相比 ,无肝期 2 0min、4 0minpH、BE值显著下降 ,血K + 、Ca2 + 水平显著降低 ,PT、APTT显著延长 ,FIB显著降低 ,体温显著下降 ,而血糖水平未发生显著性改变 ;新肝灌流恢复期 2 0min、4 0min与无肝期 2 0min、4 0min比较pH、BE、HCO3 -显著升高 ,血K + 、Ca2 + 水平显著升高 ,血糖水平亦显著升高 ,PT、APTT及FIB无明显变化。结论　无肝期较无肝前期及新肝灌流恢复期生化、血流动力学及凝血指标变化更为显著     

陕西省黄陵县克山病病情8年连续观察

目的　观察陕西省黄陵县克山病 8年来病情及相关因素的变化。方法　选择黄陵县的 6个重病村设立监测点 ,该区居民列为监测对象。 1995年至 2 0 0 2年连续 8年对该监测点克山病的发病情况监测及 3～15岁儿童内环境硒水平进行监测。结果　①潜、慢型克山病的检出率 1995、1997、1999、2 0 0 0和 2 0 0 2年依次为 4 .3%、3.6 %、7.5 %、8.0 %和 8.5 % ;②潜在型克山病的新发生率 1995、1997、1999、2 0 0 0和 2 0 0 2年依次为 5 5 .6 /万、5 3.5 /万、19.5 /万、0 /万和 2 5 /万 ;③全县 8年慢型克山病死亡 2 2例 ,15例死于慢性充血性心力衰竭 (占 6 8.2 % ) ,7例死于猝死 (占 31.8% ) ;④病区 3～ 15岁儿童发硒含量 8年均达到非病区水平。结论　陕西省黄陵县克山病的发病呈平稳低发态势 ,但潜在型克山病仍有新发     

猪屎豆、白灰毛豆在海南中线高速边坡生态恢复中的应用

为了研究猪屎豆和白灰毛豆两种灌木在公路边坡生态恢复中的实际应用效果,2012年在海南省中线高速(S21)选择骨架防护、三维网防护、普通喷播3种典型防护形式坡面进行了猪屎豆、白灰毛豆灌木种子不同配比方案恢复试验.试验结果表明,猪屎豆、白灰毛豆两种灌木的株高、冠幅、胸径、生长密度4个生长指标变化特征与前期种子配比情况有直接关系,其中冠幅和胸径指标正相关,但是与株高和生长密度指标负相关.该结果说明这两种灌木在海南省中线高速边坡(包括普通土质边坡和膨胀土劣质边坡)生态恢复中具有可行性,但是应调整灌木种子用量,确保灌木适宜的生长空间,维持灌木健壮的生长势,同时种子应合理搭配以维持后期边坡物种的多样性.这一研究结果可为海南省中线高速边坡生态恢复提供一定的参考.     

Effects of Heat Intensity and Inflow Wind on the Reactive Pollution Dispersion in Urban Street Canyon

This paper investigates the impacts of heating intensity and inflow wind speed on the characteristics of reactive pollutant dispersion in street canyons using the computational fluid dynamic (CFD) model that includes the transportation of NO, NO₂, and O₃ coupled with NO-NO₂-O₃ photochemistry. The results indicated that the heat intensity and inflow wind speed have a significant influence on the flow field, temperature field and the characteristics of reactive pollutant dispersion in and above the street canyon. With the street canyon bottom heating intensity increasing, NO, NO₂ and O₃ concentrations in street canyon are decreased. The O₃ concentration reductions are even more than the NO and NO₂ concentrations. Improving the inflow wind speed can significantly reduce the NO and NO₂ concentrations within street canyons. But the O₃ concentrations have a slight rise with wind speed increasing. The results would be useful for understanding the interrelation among reactive vehicle emissions, and provide references for urban planners.     

大连市常规公交规划思路探讨

城市常规公交系统建设是贯彻公交优先、促进高质量发展的关键.本文从分析大连市常规公交发展现状和面临问题入手,结合城市交通发展趋势,提出常规公交发展目标,在此基础上探讨了新时期常规公交规划要从公交网络、规划目标、服务模式、技术方法等四方面转变思路,强化两网融合和以人为本的思想,增强常规公交的吸引力,促进城市高质量发展.