错台处治技术在水泥混凝土路面的应用

针对水泥混凝土路面错台病害,系统介绍了环氧树脂砂浆薄层修补、增设传力杆预防性养护两种错台处治技术,以更好地指导高速公路路面养护工作。     

Solving resource-constrained multiple project scheduling problem using timed colored Petri nets

To solve the resource-constrained multiple project scheduling problem (RCMPSP) more effectively, a method based on timed colored Petri net (TCPN) was proposed. In this methodology, firstly a novel mapping mechanism between traditional network diagram such as CPM (critical path method)/PERT (program evaluation and review technique) and TCPN was presented. Then a primary TCPN (PTCPN) for solving RCMPSP was modeled based on the proposed mapping mechanism. Meanwhile, the object PTCPN was used to simulate the multiple projects scheduling and to find the approximately optimal value of RCMPSP. Finally, the performance of the proposed approach for solving RCMPSP was validated by executing a mould manufacturing example.     

轻型车用柴油机达国Ⅲ排放试验研究

通过对玉柴2.5L4F国Ⅱ柴油机进行试验优化升级来匹配某轻型车国Ⅲ机的排放要求.试验主要针对电控燃油喷射系统中的喷油器锥角、突出高度、增压器、EGR进行优化升级,结果表明样机能够满足国Ⅲ排放要求.     

车辆工程应用型本科大学生工程素质培养模式的创新与实践

从汽车工业发展对车辆工程应用型本科人才的基本素质要求出发,论述了车辆工程专业应用型本科大学生工程素质培养模式的改革,重点探讨车辆工程专业大学生工程素质培养模式、专业课群构建、教学改革、学生数字化设计和实践创新能力的培养等本科教学问题.     

客运专线运营成本组成要素分析

论述客运专线运营成本的特点,在参考和借鉴国外高速铁路及我国既有线的运营经验及研究成果基础上,重点分析客运专线运营成本中电力、材料、折旧、工资、资本成本5个组成要素的支出科目及成本构成情况,提出控制客运专线运营成本的措施,可以为我国客运专线建设和运营提供参考意见。     

海洛因暴露对子代小鼠海马凋亡相关基因表达的影响

目的 观察子宫内海洛因暴露对小鼠海马caspase-3、Bcl-2和Bax表达的影响,探讨线粒体凋亡通路在海洛因暴露引起子代小鼠神经、行为发育异常中的作用.方法 于小鼠胚龄(embryonic day)E9～E18d时,每天给孕鼠皮下注射海洛因10mg/kg,建立子宫内海洛因暴露的小鼠模型.按出生前处理将仔鼠分为空白组(Con)、盐水组(Sal)和海洛因组(Her).待仔鼠14d时取海马,应用RT-PCR和Western Blot检测caspase-3、Bcl-2和Bax的表达情况.结果 与Con和Sal组相比,Her组仔鼠的caspase-3和Bax的蛋白表达明显增加(P＜0.05),而Bcl-2蛋白表达明显下降(P＜0.05).结论 海洛因暴露可引起子代小鼠海马caspase-3和Bax表达上调,Bcl-2表达下调,提示线粒体凋亡通路可能参与了海洛因损伤小鼠神经行为发育的分子机制.     

Protective effect of glutamine pretreatment on ischemia-reperfusion injury of spinal cord in rabbits

Objective To investigate the effect of glutamine (Gln) on the content of reduced glutathione hormone (GSH) and aminoglutaminic acid (Glu) of spinal cord following ischemia-reperfusion injury. Methods Totally 40 healthy adult male rabbits were randomly divided into five groups: sham-operation group (S group), ischemia-reperfusion injury group (I/R group), low-dose glutamine group (L Gln group), median-dose glutamine group (M Gln group) and high-dose glutamine group (H Gln group). After glutamine preconditioning, the model of spinal cord ischemia-reporfasion injury was established according to Zivin's method. The general status of animals was observed and the changes of Jacobs scoring were recorded in each group. Malondialdehydes (MDA), GSH, Glu and superoxide dismutase (SOD) activity in lumbar spinal cord tissues were determined using chemical colorimetry. The neuron number and deviation rate in spinal cord anterior horn were observed histopathologically. Results There was no significant difference between L Gin group and I/R group in behavior scoring, SOD activity, content of MDA and Glu, neuron number and deviation rate of spinal cord (P>0.05); however, there was a significant difference in GSH content of spinal cord (P<0.05). M Gln group and I/R group differed significantly (P<0.05) in behavior scoring, SOD activity, content of MDA, Glu, GSH, neuron number and deviation rate of spinal cord. Between H Gln group and M Gln group, there was no significant difference in behavior scoring, content of MDA and Glu, SOD activity, neuron number and aberration rate in spinal cord (P>0.05), whereas there was a significant difference in SOD activity and Giu content (P<0.05). Conclusion Pretreatment with medium-dose glutamine has a protective effect on spinal cord ischemia-reporfasion injury in rabbits, which may be related to the maintenance of GSH content, increase of SOD activity and reduction of MDA.     

样本复杂性估计算法优化神经网络结构

在神经网络结构寻优中,样本复杂性估计算法是期望在寻优之前先对问题的规模有所估计,进而根据规模给出一个结构,使之不用从最小结构开始一一尝试。频域分析及仿真实验结果均证明了此算法的有效性。     

公路施工的安全保障设施及设备

重点阐述了公路施工中,特别是道路的养护和维修施工时,保障安全生产的设施和设备合理配置的重要性.     

大堰河桥荷载试验分析

大堰河桥是一座跨径25 m的简支波形钢腹板组合箱梁公路桥。对大堰河桥进行有限元仿真分析并实施实桥荷载试验。结果表明,大堰河桥设计施工安全可靠,研究可为今后同类型桥梁的修建提供参考。