重载车辆对路面的动荷冲击作用分析

根据达朗贝尔原理建立了车辆动荷载作用模型,借助Matlab数学工具重点分析了车辆动载在不同载重条件下的变化特征。研究结果表明,在不平整路面上运行的车辆会产生较静载更为显著的动荷作用,动荷系数在较大范围内变化,最大值可达1.8以上;由于车速、载重、路面平整度等多因素交互作用,高速重载交通对路面的破坏作用不可忽视。     

Impurity profiling and in-process testing of drugs for injection by fast liquid chromatography

Liquid chromatography (LC) is considered by many as a mature technique. Nonetheless, LC technology continues to evolve driven by the need for high-throughput and high-resolution analyses. Over the past...     

监理在桥梁施工中的作用

将结合当前公路桥梁建设过程中的实际情况,分析工程监理在公路桥梁施工过程中的作用,希望能够为今后的相关研究提供一定的借鉴意义。     

国内外规范关于水流作用下护底块石稳定质量计算方法对比

关于水流作用下护底块石的稳定质量计算，国内外均开展了大量研究，并总结提出多种计算理论，各国规范也给出不同的计算方法。因研究条件和背景有所不同，采用各种计算方法往往得到不同的计算结果，给设计人员带来较多不便。针对上述问题，梳理国内外常用规范中给出的计算方法，并结合工程案例进行对比分析，总结不同方法之间的差异以及适用条件。结果表明，水深是影响护底块石质量的敏感因素，计算方法选取时应重点考虑该因素；美国规范考虑的影响因素较为全面，具有较好的适用性；但在强紊动的水流条件下，建议对照国际通用手册中的Pilarczyk法和Escarameia & May法综合评估确定块石质量。     

档案学学科体系的作用与学科体系结构的特征

档案学的学科体系是一个历史性的概念。就目前而言,档案学的体系结构主要应包括档案学的分支学科的构成。档案学的学科体系问题,是档案学发展到一定历史阶段后,档案学自身建设所要研究的一个重要课题。一方面,对档案学学科体系的研究可以使学界对档案学的整体发展状况有一个全面概观的了解,具有良好的学术价值;另一方面,对档案学学科体系的研究也可以为档案学自身的建设和发展提供一个客观的思想导向。     

U241E型自动变速器电控系统的原理分析

广汽丰田凯美瑞2.0轿车采用了四速电控U241E型自动变速器,换挡手柄共有7个位置:P(驻车)、R(倒挡)、N(空挡)、D(行车挡)、3(中速挡)、2(中速挡)和L(低速挡)。该变速器主要由液力变矩器、机械传动机构、液压控制系统和电子控制系统等四部分组成。液力变矩器的主要作用是将发动机的动力适时地通过液力或机械的方式传递给后续机械传动部件;     

公路路面施工的质量控制

最近几年中，公路建设方面虽有了较明显的进步，施工质量也在很大程度上得到了提高，但是，公路交通上仍出现了较大的事故。这些公路交通事故的发生，不仅仅对国家的经济发展产生了阻碍作用，而且威胁着广大人民的生命财产安全。导致此类交通事故发生的客观原因是特殊的气候条件，但最根本的还是施工方在施工中对质量方面的问题没有进行严格的整治。所以我们必须对工程的施工质量足够重视，认真总结之前的教训，吸取经验，为日后公路交通的建设打好稳固的理论与实践基础。     

钢箱梁桥地震响应的有限元分析

针对典型的工程实例,基于大型有限元软件,采用纤维模型模拟梁柱单元,建立了钢箱梁桥的三维有限元模型,合理选取了强震记录,进行了罕遇地震作用下桥梁结构的弹塑性时程分析,为桥梁结构抗震设计和提高抗震安全性提供了科学依据和重要参考.     

Effects of rosiglitazone on rabbit atherosclerosis

We sought to validate magnetic resonance imaging(MRI) for documenting the effects of rosiglitazone on rabbit atherosclerosis and the possible mechanism by treatment on the lesions.24 New Zealand white rabbits were randomly divided into normal group, control group and treatment group.After 4 weeks, all rabbits underwent MRI.After examination, the number of circulating endothelial progenitor cells(EPCs) and level of lipid, glucose, nitric oxide(NO) and superoxide anion(O-2·) were measured.MRI demonstrated the regression of atherosclerotic lesions by rosiglitazone which has good correlation with histopathology.Treatment not only increased the level of EPCs and NO, but also raised the ability of inhibition of O2-·.MRI is a promising noninvasive technology to detect the effects of therapeutic interventions.Rosiglitazone slows the progression of atherosclerosis that may in part attribute to its improvement of mobilization of EPCs and the reduced oxidative stress.     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.