中铁快运货物包装的管理创新与实践

1中铁快运包装管理目前存在的主要问题1.1包装作业不规范一是现场人员责任心不强,操作不正确,未能完全按照包装标准进行规范作业。二是对客户已包装、但不符合运输条件的货物未正确引导客户采取二次包装。据不完全统计,中铁快运每年因包装不合格所造成的理赔事故几乎     

汽车零部件包装器具标识设计

鉴于汽车生产的批量性及其零部件属性的多样化,以物流包装标识基本理论为基础,对汽车生产过程中所需的托盘、工位器具、塑料箱、纸包装等包装器具进行标识设计。使用结果表明,所设计的标识设计合理、布置恰当、易于识读。     

冠状动脉支架内再狭窄发生机制的研究进展

经皮冠状动脉介入术是目前治疗冠状动脉粥样硬化性心脏病的主要有效的治疗手段,血管支架尤其是药物洗脱支架极大程度上改善了冠心病患者的疗效和预后。与支架相关的病理主要表现为支架内再狭窄引起的进行性心绞痛和支架内血栓导致的急性心肌梗死。支架内再狭窄是由生物、机械、技术及与患者自身相关的复杂相互作用介导形成的病理性新生内膜增生,有关其发病机制的研究正不断深入。本文通过血管内皮损伤、血管平滑肌细胞增殖迁移、血管外基质重构、炎症反应以及新生动脉内膜粥样硬化等方面对其进行综述,深入探讨其形成的影响因素及临床意义。     

儿茶酚-O-甲基转移酶基因多态性rs4680对抗精神病药物疗效的影响

目的应用Meta分析的方法探讨儿茶酚-O-甲基转移酶(COMT)基因的主要单核苷酸多态性(SNP)rs4680对抗精神病药物疗效的影响。方法检索Pubmed、Embase、Cochrane Library、中国知网和万方数据库,收集所有研究rs4680与抗精神病药物疗效的关系的文献,提取相关数据并用Stata14.0软件在显性模型下进行统计分析。以合并比值比(OR)和95%可信区间(95%CI)确定相关性;进行敏感性分析考察结果的稳定性;绘制漏斗图考察发表偏倚的大小。结果共纳入13篇研究,包含1 439例精神分裂症患者。合并结果显示,在显性模型下,rs4680显著影响抗精神病药物的疗效,与GG基因型携带者相比,AA或AG基因型携带者使用抗精神病药物治疗后获得的应答率更高(OR=1.31,95%CI:1.04~1.66),Egger检验未发现显著的发表偏倚(P=0.082),敏感性分析发现去掉漏斗图中离群的两个小样本研究后,合并结果无显著性差异(OR=1.25,95%CI:0.98~1.58),表明meta分析结果存在一定的不稳定性。结论 rs4680可能会影响抗精神病药物的疗效,由于受到研究数目的限制以及不稳定性因素的存在,本结果仍需进一步验证。     

Impurity profiling and in-process testing of drugs for injection by fast liquid chromatography

Liquid chromatography (LC) is considered by many as a mature technique. Nonetheless, LC technology continues to evolve driven by the need for high-throughput and high-resolution analyses. Over the past...     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

38000dwt杂货船危险货品清单与船舶优化设计

38000dwt杂货船的总体设计中,需要尽可能多地考虑船东的运输利益,载运的货物品种尽可能地多样并保障安全。该船初步设计阶段就考虑了载运各种危险货物对船舶环境的需求,介绍了几种比较特殊货品的要求,通过该杂货船各类形式比较全的货品清单探讨该类型的船舶设计特点。整个设计工作中,结合危险品货物运输规则及船东的要求,采用切合实际且经济实用的船舶配置,实现船舶的多用途性能。     

运一台冰箱咋就这么难?

笔者有一台9成新的西门子冰箱,在北京西客站附近的苏宁电器购买时价格3000多元,用了6个月后,因为举家搬迁,这台冰箱就面临着2种命运:要么低价贱卖,要么运回老家。这台冰箱身高156厘米,宽55厘米,长55厘米,上下双开门,电子温控,雪白的冰箱壁,打开冰箱门,就可以看到箱体里晶莹剔透的托盘和抽屉,虽不属于奢侈华丽的贵族冰箱,但对一介平民来讲,也算是台高品质的家用电器了。笔者权衡再三,决定     

F关于《国际船舶安全载运包装的辐放射性核燃料、钚和高放射性废料（INF）规则》修正案生效的公告

国际海事组织海上安全委员会第79届会议于2004年12月10日以MSC178（79）号决议通过了《国际船舶安全载运包装的辐放射性核燃料、钚和高放射性废料（INF）规则》（以下简称“INF规则”）的修正案。