CATIA-V5的知识工程优化功能在汽车产品开发上的应用

知识工程优化是通过捕捉、优化设计意图，使用户可以按目标进行优化设计的一种优化方法。介绍了与知识工程优化有关的概念和采用CATIA—V5软件知识工程优化功能进行产品优化设计的流程，并以油底壳体积优化设计和刮雨器的结构功能优化设计为例，提出了CATIA—V5知识工程优化的方法。     

金属带式无级变速器电液控制系统的试验研究

通过对金属带式无级变速液压控制系统功能进行分析，把该系统分为夹紧力控制和速比控制系统。设计了金属带式无级变速器电—液控制系统，对控制阀特性进行了研究，为夹紧力控制系统和速比控制系统分别设计了控制器。最后对所设计的CVT控制系统进行了实车道路试验，取得了较好的效果。     

CARD/1系统在互通立交设计绘图上的应用与开发

通过对CARD/1系统在T型（Y型）互通式立体交叉设计绘图上的二次开发，使T型（Y型）互通式立体交叉的设计绘图达到一体化。     

An optimal data-splitting algorithm for aircraft scheduling on a single runway to maximize throughput

In this research, we present a data-splitting algorithm to optimally solve the aircraft sequencing problem (ASP) on a single runway under both segregated and mixed-mode of operation. This problem is formulated as a 0–1 mixed-integer program (MIP), taking into account several realistic constraints, including safety separation standards, wide time-windows, and constrained position shifting, with the objective of maximizing the total throughput. Varied scenarios of large scale realistic instances of this problem, which is NP-hard in general, are computationally difficult to solve with the direct use of commercial solver as well as existing state-of-the-art dynamic programming method. The design of the algorithm is based on a recently introduced data-splitting algorithm which uses the divide-and-conquer paradigm, wherein the given set of flights is divided into several disjoint subsets, each of which is optimized using 0–1 MIP while ensuring the optimality of the entire set. Computational results show that the difficult instances can be solved in real-time and the solution is efficient in comparison to the commercial solver and dynamic programming, using both sequential, as well as parallel, implementation of this pleasingly parallel algorithm.     

HXD1型机车自动驾驶系统设计与应用

主要介绍HXD1型交流传动电力机车的自动驾驶系统方案设计与应用情况,以机车改动最小、成本最低为原则,通过加装自动驾驶系统设备、通信及供电线缆实现自动驾驶功能。通过机车自动系统的成功运用,降低了人工劳动强度,杜绝了人为失误因素,提升了机车操纵水平和操纵一致性。     

基于灰色残差GM（1，1）模型的道路交通量预测的研究

道路交通体系是一个多因素、多层次、多目标的复杂系统。其中交通量信息系统具有明显的层次复杂性,结构关系的模糊性,动态变化的随机性,指标数据的不完全和不确定性。由于技术方法、人为因素、自然环境变化的影响,造成各种数据误差、短缺甚至虚假现象,系统的作用机制不明确,系统的状态、结构、边界关系难以精确描述,属于典型的灰色系统。在作量化、模型化、实体化研究时,能作为反映系统主要动态特征的数据是很少的。由于环境对系统的干扰,系统信息中原始数据序列往往呈现离乱情况,离乱数列即为灰色数列或称灰色过程,灰色理论利用那些较少的或不确切的表示系统行为特征的原始数据序列作生成变换后建立微分方程,对灰色过程建立的模型称为灰色模型（Greymodel）,简称GM模型。本文从理论上介绍了GM（1,1）模型和灰色残差GM（1,1）模型建立的一般过程,然后将其应用于交通量预测的实际例子中。预测结果表明,该方法是可行的。     

Flow Stress Model of Stainless Steel OCr13Ni5Mo at Elevated Temperature

For a more accurate forming calculation and numerical simulation of hydraulic turbine blade,experimental studies on the flow stress of stainless steel OCr13Ni5Mo were carried out upon Gleeble-1500 thermal simulator under different deformation conditions.The results then were analyzed and the effects of all influencing factors were summarized consequently.New mathematic models were conceived.Utilizing the software Matlab,regression coefficients were calculated by the least square method.The model has an eminent capability of curve-fitting performance with impact structure whose correlation coefficient is up to 0.908 0 and the cosine coefficient is 0.995 8.All mathematic models and process parameters can be used in engineering calculations or computer simulations.     

生存素在5-氟尿嘧啶诱导人绒癌细胞株JAR凋亡中的作用

目的探讨生存素(survivin)在化疗药物5-氟尿嘧啶(5-Fu)诱导的人绒癌细胞株(JAR)凋亡中的作用。方法用JAR细胞株进行培养传代,以不同浓度5-Fu作用于JAR细胞,MTT方法观察5-Fu对JAR细胞生长的抑制情况,流式细胞仪检测细胞凋亡率,用逆转录聚合酶链(RT-PCR)和免疫印迹技术(Western-blot)方法检测survivin基因和蛋白的表达。结果①5-Fu对JAR细胞的生长具有抑制作用,并有浓度和时间的依赖性;②5-Fu诱导JAR细胞凋亡,凋亡率随浓度而增加;③5-Fu作用后survivin基因和蛋白表达减少,随浓度增加而减少。结论5-Fu可能是通过降低survivin表达水平,诱导JAR细胞凋亡。     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

5-羟色胺转运体基因多态性和抑郁症的发病、性别、严重程度及自杀行为的相关性

目的探讨中国汉族人群5-羟色胺转运体启动区(5-HTTLPR)基因多态性和抑郁症的发病、性别、严重程度及自杀是否相关。方法应用聚合酶链式反应(PCR)扩增技术测定150例抑郁症患者和150例正常对照者的5-HT-TLPR基因型和等位基因,分别验证各种基因型与中、重度抑郁症发病、性别及自杀行为的相关性。结果病例组SS、LS基因型及S等位基因频率均高于对照组(26.0% vs.20.0%;52.7% vs.46.0%;52.3% vs.43.0%;P均<0.05);两组性别分层比较,女性S等位基因频率高于对照组(55.3% vs.43.6%,P<0.05);病例组严重程度分层比较差异无统计学意义(P>0.05);病例组有无自杀行为分层比较,有自杀行为患者SS基因型频率(37.3% vs.20.2%)及S等位基因频率(61.8% vs.47.5%)均高于无自杀行为患者(P<0.05);抑郁自杀组性别分层比较未显示显著性差异(P>0.05);抑郁自杀组病情程度分层比较,重度抑郁自杀者SS基因型频率(42.5% vs.18.2%)及S等位基因频率(68.7% vs.36.4%)均高于中度抑郁自杀者(P<0.05)。结论在中国汉族人群中,5-HTTLPR多态性和抑郁症相关。S等位基因可能是抑郁症的易感基因,特别是女性,SS型可能是抑郁症易感基因型;S等位基因可能是抑郁症患者自杀的危险基因,SS基因型人群可能是抑郁症患者自杀的危险人群,特别是携带S等位基因的重度抑郁症患者更易自杀。