STUDY ON THE THERAPEUTIC EFFECTS OF GINSENOSIDE Rg-1 AND GASTRODINE ON AD MODEL RATS INDUCED BY β-AMYLOID PEPTIDE (25-35)

Objective To study the therapeutic effects of Ginsenoside Rg-1 and Gastrodine on rats model of Alzheimer's disease(AD). Methods Aggregated β-Amyloid peptide (25-35) was injected into the lateral ventricle of rats to establish AD models. Ginsenoside Rg-1, Gastrodine and Ginsenoside Rg-1+Gastrodine were intraperitoneally injected into rats of each test group(Ginsenoside Rg-1∶10mg/kg·day; Gastrodine 100mg/kg·day) for 4 weeks, the rats of control group received equal volume of saline. Passive avoidance task and Morris maze test were done to assess the ability of learning and memory. The content of superoxide dismutase (SOD), malondiadehyde (MDA), total-antioxidative capability (T-AOC), Choline acetyltransferase (ChAT) and acetylcholinesterase (AchE) in brain tissue were measured. Results Ginsenoside Rg-1 and Gastrodine significantly improved learning and memory deficits in the rats with AD induced by β-Amyloid peptide (25-35) (P<0.05). Ginsenoside Rg-1+Gastrodine group were better than Ginsenoside Rg-1 group and Gastrodine group (P<0.05). Ginsenoside Rg-1 reduced the increase of SOD, MDA, but inhibited the decrease of T-AOC, AchE and ChAT; Gastrodine reduced the increase of SOD, MDA, while inhibited the decrease of T-AOC. Gastrodine could also prevent the activity of ChAT and AchE decline in AD rats. Conclusion Both Ginsenoside Rg-1 and Gastrodine have therapeutic effects on rats with AD; Ginsenoside Rg-1 and Gastrodine injection at the same time were better than only using one of them. Their mechanisms might different. Ginsenoside Rg-1 can not only inhibit peroxidation but also increase the activity of AchE and ChAT in brain tissue, while Gastrodine can inhibit peroxidation only, but it can't prevent the decline of ChAT and AchE activity in AD rats.     

Changes in the shelf macrobenthic community over large temporal and spatial scales in the Bohai Sea, China

Over the past 20 years, the Bohai Sea has been subjected to a considerable human impact through over-fishing and pollution. Together with the influence of the Yellow River cut-off, the ecosystem experienced a dramatic change. In order to integrate available information to detect any change in macrobenthic community structure and diversity over space and time, data collected during the 1980s and the 1990s from 3 regions of the Bohai Sea (Laizhou Bay, 16 stations, 37–38°N, 119–120.5°E; central Bohai Sea, 25 stations, 38–39°N, 119–121°E; eastern Bohai Bay, 12 stations, 38–39°N, 118.5–119°E) were reanalyzed in a comparative way by means of a variety of statistical techniques. A considerable change in community structure between the 1980s and the 1990s and over the geographical regions at both the species and family level were revealed. After 10 years, there was a considerable increase in abundance of small polychaetes, bivalves and crustaceans but decreased number of echinoderms. Once abundant in Laizhou Bay in the 1980s, a large echinoderm Echinocardium cordatum and a small mussel Musculista senhousia almost disappeared from the surveying area in the 1990s. Coupled with the increased abundance was the increased species richness in general whereas evenness was getting lower in central Bohai Sea and Bohai Bay but increased in Laizhou Bay. K-dominance plot showed the same trend as evenness J′. After 10 years, the macrobenthic diversity in the Bohai Sea as a whole was slightly reduced and a diversity ranking of central Bohai Sea > Laizhou Bay > eastern Bohai Bay over space was also suggested. Sediment granulometry and organic content were the two major agents behind the observed changes.     

酵母菌活性物质及多糖对红细胞免疫粘附能力的影响

用 CD35单抗阻断实验研究酵母菌活性物质 (yeast competence products,YCP)和酵母多糖(zymosan A,ZA)增强红细胞免疫粘附能力并探讨其作用机理。结果显示 :YCP和 ZA组在 CD35单抗阻断前 RBC· C3 b RR率分别为 2 4 .73± 2 .72 ,2 2 .82± 3.6 6 ,与对照组 (12 .33± 1.0 7)比较有非常显著性差异 (P <0 .0 0 1)。CD35单抗阻断后 RBC· C3 b RR率分别为 6 .4 5± 1.86、6 .4 5± 1.2 9,与阻断前比较有非常显著性差异 (P <0 .0 0 1)。提示 YCP和 ZA能增强红细胞免疫粘附能力 ,其机理可能与红细胞膜上 CR1表达增强有关。     

35kV小型化变电站完善改造工程的建议

随着当前农网改造的逐步深化,35kV小型化变电站将被改造成"无人值班,有人值守"的变电站,文中提出了四点值得注意的问题,并给出了相关建议.     

日产坎顿工厂的生产管理

从多方视角介绍了日产汽车公司美国坎顿工厂的建设背景和投产情况,简要概括了坎顿工厂所采取的提高劳动生产率的生产集中化战略。     

地铁用35kV交流电力电缆结构与参数选择分析

本文结合相关工程经验,分析了地铁供电系统35 kV交流电力电缆结构及性能,介绍了导线及线芯截面、电缆绝缘水平、导体屏蔽及金属屏蔽层截面、电缆及阻燃类别等项参数选择并提出选择建议,对电缆选择设计有一定的参考价值。     

35CrMnSiA高强度螺栓断裂失效分析

采用理化实验对实装实验中断裂的35CrMnSiA高强度螺栓进行了失效分析.结果表明,该型螺栓在实装实验中发生的断裂不同于其在预装中发生的氢脆断裂,符合应力腐蚀断裂的特征.结合螺栓实际受力情况、工作环境综合分析,得出了螺栓在实装实验中发生的断裂属于海洋大气环境造成的应力腐蚀断裂.提出了以更换镀层、提高成品的检测和分选能力来提高螺栓抗延迟断裂能力.     

揭开B＆W35MC主机缸盖与缸套的水套漏水达6年之久谜底

文章介绍了B＆W35MC主机水套漏水的发生以及解决过程。因主机水套漏水不仅给轮机部管理带来相当大的麻烦，而且容易导致机械设备甚至船舶更大的险情与事故发生。通过解剖水套漏水这起故障，其深刻的教训告诫我们：只有采取认真、细致和正确的工作态度，才能科学管理与维护机械设备。     

基于GPRS的多点无线实时温度检测系统

针对传统温度检测系统中存在的温测上限低、功耗大、传输速率低等问题，采用新型薄膜铂温度传感器设计了一种基于GPRS的多点无线实时温度检测系统，并使用正反馈型线性校正电路进一步提高了系统的测量准确度。多次测试结果表明，该系统具有高度的准确性、灵敏性和实用性。     

城市轨道交通35kV母线保护配置方案

结合城市轨道交通中压供电网络的接线形式,分析了目前地铁工程供电系统中压网络保护配置方案中存在的不足,提出了几种母线保护的配置方案,并进行了方案比较及经济分析。重点分析了基于GOOSE网络的35kV母线保护方案。