脑胶质细胞瘤患者IL-6的表达及细胞免疫功能的变化

目的　研究脑胶质细胞瘤患者外周血中白细胞介素 6 (IL 6 )的含量、红细胞免疫功能和T淋巴细胞亚群的变化规律 ,探讨它们之间的相互关系及临床意义。方法　采用酶联免疫吸附 (ELISA)法测定患者IL 6的含量 ;免疫黏附法测定红细胞免疫活性及其调节功能 ;链亲和素 过氧化物酶 (S P)一步法测定CD3、CD4、CD8的细胞数。结果　脑胶质细胞瘤组IL 6含量较对照组明显降低 (P <0 .0 5 ) ;红细胞C3b受体 (RBC .C3bR)、红细胞免疫调节促进因子(RFER)亦明显降低 (P <0 .0 0 1) ,而红细胞免疫复合物 (RBC .ICR)、红细胞免疫调节抑制因子 (RFIR)则明显升高 ;CD3、CD4细胞数明显降低 (P <0 .0 1) ,而CD8无明显差异 (P >0 .0 5 )。结论　脑胶质细胞瘤患者出现免疫功能低下 ,检测患者IL 6含量、红细胞免疫功能及T细胞亚群活性在脑胶质细胞瘤的发生、发展、治疗、转归及预后方面具有重要的临床指导意义。     

A Distributed and adaptive framework for provisioning QoS in IPv6 networks

A distributed and adaptive framework （DAF） was proposed for provisioning quality of service （QoS） in IPv6 network. In DAF, per-flow admission control and resource reservation, in conjunction with a new IPv6 flow label mechanism, can be performed instantaneously in a fully distributed and independent fashion at the edge of network without hop-by-hop signaling. The flow label helps in resource reservation and packets forwarding for aggregated traffic on an edge-to-edge path basis. In addition, a bounded directional probing technique for DAF was designed to reconfigure resource reservation adaptively between every pair of edge router for aggregated traffic according to the fluctuation of its traffic load. The simulation results show that DAF provides QoS guarantees to individual flows with minimal overhead, as well as keeping the scalability characteristic like DiffServ.     

MP2P网络的移动节点域间预切换方法

移动P2P网络具有高度动态性,但节点的频繁移动影响整个网络的可达性,降低了网络的服务质量.为了维护节点的可达性需要减少节点移动时的切换时延,为此文中提出了基于超级节点的分层预切换方法HPH.该方法在基于超级节点分层模型的基础上引入移动IPv6的快速切换的思想,对节点的域间移动采用预切换机制,解决网络中因节点频繁移动而带来的负面影响.仿真结果分析表明,较之传统KaZaA切换方法,HPH方法的切换时延降低了20.5％,丢包率降低了10.2％.     

隔离设施对BRT运行速度的影响分析

为了提高BRT的安全运行速度，以增强BRT的安全性、高效性为出发点，通过系统分析有无隔离设施、隔离设施的种类、隔离设施的安装方式以及驾驶员心理等影响BRT运行速度的因素，比较不同路段BRT运行速度的差别。结果表明，BRT在有物理隔离的专用道上的运行速度比无物理隔离专用道上高38．14％，比合用公交专用道高41．49％。     

3,6-[二甲氨基]-二苯骈碘杂六环枸橼酸盐对离体豚鼠心脏钙反常的保护作用

观察了ＩＨＣ－６５对离休豚鼠心脏钙反常的影响，结果表明：ＩＨＣ－６５可使冠脉流出液中ＣＰＫ和蛋白质漏出量比钙反常组明显减少。同时升高心肌ＣＰＫ和ＧＳＨｐｘ活性，减少ＭＤＡ的生成。说明ＩＨＣ－６５对离休豚鼠心脏钙反常有保护作用。其机制可能与抑制脂质过氧化作用有关。     

A problem of limited-access special lanes. Part I: Spatiotemporal studies of real freeway traffic

Most special-use freeway lanes in the US, whether reserved for carpools, toll-paying commuters or both, are physically separated from the adjacent regular-use lanes by some form of barrier. Vehicle movements in and out of a special lane of this type are permitted only at select access points along the route. The barrier at each select point might open for a distance of 400 m or so. Limiting access in this way is said to reduce the “turbulence” that might otherwise occur were the special lane not to have a barrier, such that vehicles could instead enter or exit that lane anywhere along its length.Yet, real freeway traffic studied in spatiotemporal fashion shows that access points are prone to become bottlenecks. The problem occurs when traffic in the regular lanes becomes dense, as commonly happens during a rush. Drivers then seek refuge in the special lane in greater numbers. Since the vehicular maneuvers through the access point are focused within a limited physical space, they can become disruptive and further degrade traffic. Degradation can occur both in the special lane and in the adjacent regular ones. The damage can be worse than when there is no barrier to limit special-lane ingress and egress.The problem is shown to be reproducible across sites and across days at each site. Policy implications are discussed. Select designs and policies to address the problem are thereafter explored in Part II of the paper using traffic simulation.     

U6和let-7a作为定量检测miRNAs的内参在大鼠软骨中稳定性的比较

目的比较U6和let-7a两种内参在RT-qPCR方法检测大鼠股骨头软骨样本microRNAs(miRNAs)的稳定性。方法取软骨生成过程的新生(D0)、断乳(D21)、性成熟(D42)3个时间节点的雌性近交系DA大鼠股骨头软骨,提取总RNA,用RT-qPCR方法分别在U6和let-7a两种内参体系下,检测miR-1、-25、-26a、-140、-146a、-150、-181a、-195、-223、-337等的表达,并与课题组前期获得的二代测序绝对定量结果进行比较,综合评价两种内参的稳定性。结果在D42样本中U6(P=0.045)、let-7a(P=0.021 5)的相对值出现了显著性差异;在两种内参体系中miR-26a、-140、-223、-337的表达趋势相同,miR-1、-146a差异无统计学意义,miR-25、-150、-181a、-195都出现了显著性差异(P<0.05)。综合二代测序绝对定量结果比较,let-7a稳定性优于U6。结论 let-7a稳定性优于U6,更适合做软骨miRNA定量的内参。     

GRAVINER Mark6 OMD监控与管理技术研究

文章针对GRAVINER Mark6 OMD调试和维护管理困难等问题,分析其系统结构、新技术特点,并提出了管理与维护方法及失效时导致曲轴箱爆炸事故处理办法,对船舶机电调试及管理工作有一定的参考意义。     

信控交叉口上游港湾公交停靠站仿真研究

布设于信控交叉口上游处的港湾式公交停靠站是一种常见的设站形式,但对其布设位置并无明确标准。基于Vissim软件进行仿真,分析不同饱和度下的不同设站位置对运行车流的延误影响,找到不同饱和度下的最佳设站位置。通过对乌鲁木齐市南昌路口公交站点进行优化,得出其进口道延误有所减少的结论。     

基于Paramics的ETC专用车道布设位置仿真

研究了高速公路收费站ETC车道的设置位置与整个收费站的运行效率的关系,从而优化车道布置。基于Paramics仿真软件,以上海市某高速公路主线收费站出口为例,以降低车辆运行延误、减少收费站排队长度为优化目标,通过对比新增ETC专用车道分别设置在不同位置下的收费站运行效率,研究ETC专用车道的最佳布设位置。经过分析,在收费车道数较多的情况下,两侧各设置1条ETC车道有利于减少车辆交织,提高收费站的运行效率。