急性髓细胞白血病FLT3-ITD基因突变的检测及其临床意义

目的 探讨急性髓细胞白血病(acute myeloid leukemia,AML)患者人Fms样酪氨酸激酶3内部串联重复(Fms-like tyrosine kinase3-intenal tandem duplication,FLT3-ITD)基因突变及其临床意义.方法 采用聚合酶链反应-变性高效液相色谱(polymerase chain reaction-denaturing high performance liquid chromatography,PCR-DHPLC)方法检测60例初治AML患者和10例对照组骨髓FLT3-ITD基因突变.结果 60例AML患者FLT3-ITD突变阳性率21.67%(13/60),10例对照组均未检测到该突变;FAB各亚型FLT3-ITD突变率不同,有M3型突变率较高的趋势;FLT3-ITD阳性组外周血白细胞数、骨髓白血病细胞比例高于FLT3-ITD阴性组(P<0.01);FLT3-ITD阳性组完全缓解(CR)率低于FLT3-ITD阴性组(P<0.05).结论 FLT3-ITD基因突变多见于M3患者,FLT3-ITD阳性者具有外周血白细胞数、骨髓白血病细胞比例高、CR率低的特点.FLT3-ITD基因突变可作为预测AML预后的一个指标.     

Union examination of AFP, AFU, AFPL3 and γ-GT in early diagnosis of primary liver cancer

Objective To explore the significance of union examination of blood serum liver cancer tracers in the early diagnosis of liver cancer. Methods We observed and compared the level of blood serum liver cancer tracers armor embryo protein (AFP), crag algae glycosidase (AFU), armor embryo protein heteroplasmon (AFPL3) andγ-Gu Anxian transferase (γ-GT) in early time for primary liver cancer patients and hepatitis liver cirrhosis patients and those chronic hepatitis B patients who had liver cancer family history. Results Finally among the 30 patients in the early liver cancer group, 23 were positive with AFP, 20 with AFU, 15 with AFPL3 and 21 with γ-GT. Five were found positive with blood serum AFP, AFPL3, AFU and γ-GT at the same time; 5 with AFP, AFPL3 and γ-GT; 5 with AFP, AFU and AFPL3; 7 with AFP, AFU andγ-GT. By contrast, in the control group, among the 30 hepatitis liver cirrhosis patients and those chronic hepatitis B patients with liver cancer family history, 11 were found positive with AFP, 3 with AFPL3, 12 with AFU and 14 with γ-GT. None of the patients were found positive with union examination of AFP, AFPL3, AFU and γ-GT in the blood serum at the same time. Conclusion The union examination of AFP, AFU, AFPL3 and γ-GT is significant to the early diagnosis of primary liver cancer.     

3S技术集成及其在公路测设中的应用

介绍了GPS,RS,G IS以及3S集成技术的定义、内容、特征;并阐述了4种集成方式及其在公路测设中的应用,为开发和推广3S技术提供参考。     

纯六方相钛酸锌粉体制备和表征

采用溶胶-凝胶法,用Ti（OC4H9）4、Zn（NO3）2.6H2O、无水乙醇、冰醋酸等原料,利用直接升温和保温-升温两种方法合成超细的六方相ZnTiO3粉体.利用TG-DSC、XRD、SEM等测试分析手段对凝胶的热分解、相转变以及粉体结构形貌进行了表征.实验结果表明：ZnTiO3凝胶的热分析中,前躯体的热重变化主要分为三个阶段,其中DSC曲线在770820℃和850930℃间有多个小的吸热放热峰出现,对应于复杂的相变.在粉体制备过程中,先于700℃保温3 h再850℃加热5 h的处理,可以获得单一的六方相Zn-TiO3粉体.     

Voxelizating 3D mesh models with gray levels

A novel algorithm to voxelize 3D mesh models with gray levels is presented in this paper. The key innovation of our method is to decide the gray level of a voxel according to the total area of all surfaces contained by it. During the preprocessing stage, a set of voxels in the extended bounding box of each triangle is established. Then we travel each triangle and compute the areas between it and its set of voxels one by one. Finally, each voxel is arranged a discrete gray level from 0 to 255. Experiments show that our algorithm gets a comparatively perfect result compared with the prevenient ones and approaches the original models in a more accurate way.     

西安地铁盾构施工对古城墙影响

针对西安地铁2号线盾构施工下穿古城墙问题,在考虑城墙损伤的前提下,采用三维弹塑性有限差分法FLAC 3D软件模拟了不同加固措施工况下盾构施工对西安城墙北门的影响,得出了盾构掘进过程中城墙的沉降规律,并对该规律进行了分析.研究结果表明,采取钻孔灌注桩及化学注浆复合加固措施可以有效地保证城墙安全,为西安地铁2号线的施工及保护古城墙提供了指导性的建议,并为日后有关黄土地区的盾构施工提供了参考.     

WiMAX技术在船舶通讯中的应用研究

本文主要对作为3G技术之一的WiMAX技术应用在航海通信中的可行性进行了分析,对采用WiMAX技术的AIS系统在通信方式上提出了新的解决方案,为整个航海通讯提供了新的通信模式。     

网络化数控加工3D浏览器的研制

建立了网络化数控加工系统结构,研制出适于网络化数控加工的3DS浏览器,可浏览3D场景中的所有信息,并可将CAD／CAM系统中复杂的三维零件实体导入该浏览器中．另外,该浏览器还可将各工步的数控代码以图形化格式贴合在所需加工工件的实体表面上,使本地数控机床操作者清晰识别异地所传各工步的数控代码．     

FEMUR SHAPE RECOVERY FROM VOLUMETRIC IMAGES USING 3-D DEFORMABLE MODELS

IntroductionThe rupture of the anterior cruciate ligament( ACL) has become the most common knee in-juries.In operation of ACL reconstruction,thesurgeons have to find the optimal attachmentpoints resulting in a low anisometry of the graft,while preventing impingement between the graftand the femoral notch.Markus Fleute andStéphane lavallée[1] proposed a real- time systemfor computer- assisted ACL surgery.A recentadvance in surgery is minimally invasive tech-nique that can avoid the large…     

AN EFFECTIVE HUMAN LEG MODELING METHOD

IntroductionFFD is a widely used technique in the field ofsolid modeling and computer animation.Seder-berg and Parry introduced the conceptof FFD[1] ,and Barr provided the basic deformation methodfor FFD[2 ] .Although there are several versionsof FFD in the related literature[3～ 6 ] ,they havethe same basic idea:1 Constructa lattice space.The space can be of any shape,not restricted toparallel- piped cube[5 ] .2 Embed the object intothe lattice space.In other words,impose a localcoordi…