Investigation of tailpipe and evaporative emissions from China IV and Tier 2 passenger vehicles with different gasolines

The limited understanding of vehicular emissions in China, especially evaporative emissions, is one obstacle to establishing tighter standards. To evaluate tailpipe and evaporative emissions, two typical China IV vehicles and one Tier 2 vehicle with an onboard refuelling vapour recovery (ORVR) system were selected and tested. One of the China IV vehicles was fuelled with gasoline, E10 and M15, respectively, to investigate the effect of fuel properties on vehicular emissions. For each vehicle, cold-start tailpipe emission tests were conducted first, followed by an evaporation test. Based on the emission factors and real-world vehicle activity data, the annual tailpipe and evaporative hydrocarbon (HC) emissions of each vehicle were calculated and compared. The results show that E10 and M15 significantly reduced the tailpipe CO and particle number (PN) emissions but seriously aggravated the NOx emissions, especially for M15. The hot soak losses (HSLs) and diurnal breathing losses (DBLs) were slightly impacted by the fuel properties. The annual evaporative emissions with E10 and M15 were higher than that with gasoline. The ORVR system effectively controlled the evaporative emissions, especially for DBLs. Evaporative emissions from the China IV vehicles were 1.1–1.4 times the tailpipe HC emissions. Additionally, the evaporative emission factors of the China IV vehicles were almost 50% lower than the standard (2.0 g/test), whereas their annual evaporative emissions were almost 1.8–2.8 times higher than those from the Tier 2 vehicle. Therefore, controlling evaporative emissions currently remains a great need in China, and the ORVR might be a recommended evaporative control technology.     

Environmental and transport effects of warehouse relocationing: evidence from Norway

Reducing traffic volumes and CO2-emissions from freight transport has proven difficult in many countries. Although the increasing suburbanization of warehouses is seen as a relevant land use trend, comprehensive analyses of their impact remain scarce. This study uses real data in modeling transport, costs, environmental and modal effects from warehouse relocations around Oslo and Trondheim (Norway). Results indicate that for Oslo, traffic performance (ton-km), CO2-emissions, and transport costs increase following warehouse suburbanization. For Trondheim, transport performance and CO2-emissions increase less, while transport costs decrease marginally. We conclude that specific case characteristics (geography and trade patterns) are important in determining the strength and direction of effects, and expect that common concomitant developments (warehouse centralization and consolidation) would lead to more pronounced results. Our findings confirm some, but challenge other, findings from the relatively scarcely literature available. Finally, the study's more general insights and observations can help advance similar analyses beyond Norway.     

基于多源数据的公交车能耗碳排放测算模型

公交车能耗碳排放强度与车辆、线路和驾驶员有显著相关关系，为精准刻画其能耗碳排放强度特征，整合OBD监测数据、加油(气)数据、运营排班数据等多源数据资源. OBD监测数据和加油(气)数据呈显著的线性关系，证明修正后的OBD监测数据可满足分析要求. 搭建“速度-能耗碳排放强度曲线”测算模型，幂函数关系的拟合优度R2 =0.972 6 为最高. 实证研究发现，平均速度在10~60 km/h 变化时，液化天然气(LNG)车比柴油车能耗碳排放强度高 3.3%~33.7%，双层车比铰接车高2.4%~13.3%；LNG铰接车在不同线路、相同速度下的强度相差9.6%；不同驾驶员在相同线路的能耗碳排放强度可相差24.2%. 模型为各城市基于多源数据开展公交能耗碳排放目标设定提供数据支撑.     

Caterham Seven 420R v Porsche 911 GT3 RS

在赛道作为一条经验法则,除非420R在打滑,否则其实它根本没用尽全力。它会转向不足——其实有时还挺有用的,如果你非要找到它的极限并再用力推过头一点点的话;但如果你就是入弯时对前胎要求过高那它就那么有帮助了。Seven之妙处在于驾驶者可以立刻知道当前的情况。你完全可以在入弯到     

羟基喜树碱对人胆管癌QBC939裸鼠移植瘤PS2、COX-2的影响

目的探讨羟基喜树碱对人胆管癌QBC939裸鼠移植瘤的乳癌相关肽(PS2)、环氧合酶-2(COX-2)的影响,分析PS2、COX-2与肿瘤发生、发展的关系。方法建立人胆管癌QBC939细胞株裸鼠皮下移植瘤模型,将30只裸鼠随机分成对照组、羟基喜树碱低剂量组和羟基喜树碱高剂量组,观察移植瘤体生长情况,RT-PCR法检测瘤体内PS2、COX-2 mRNA表达。结果与对照组比,羟基喜树碱低、高剂量组都可使移植瘤体的PS2 mRNA表达增高;COX-2 mRNA表达降低,且瘤体生长减慢,与对照组比较差异有统计学意义(P<0.01)。结论羟基喜树碱可降低移植瘤COX-2 mRNA表达,增高移植瘤体的PS2 mRNA表达,并使人胆管癌裸鼠移植瘤生长减慢。     

Study on T lymphocyte subsets and NK cells in patients with Graves＇ disease combined with type 2 diabetes

Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM.     

健胃愈疡颗粒对慢性胃炎伴幽门螺杆菌感染胃黏膜PAF、PS2的表达及对上皮细胞凋亡的影响

目的观察健胃愈疡颗粒(JWYY)对幽门螺杆菌相关性胃炎胃黏膜乳癌相关肽(PS2)和血小板活化因子(plate-let activating factor,PAF)表达的变化,并分析其可能的作用机制。方法80例幽门螺杆菌感染慢性胃炎患者随机分为2组,治疗组42例给予健胃愈疡颗粒治疗,对照组38例给予西药三联药物治疗。应用胃镜下活检胃黏膜组织快速尿素酶和Warthin-Starry染色法检测幽门螺杆菌,应用Western blot检测PS2、PAF表达变化。应用末端转移酶介导的dUTP切口末段标记法(TUNEL)检测细胞凋亡。第4周复查胃镜。结果治疗组凋亡指数明显比对照组减少(P<0.05),治疗组总有效率高于对照组(P<0.05)。Western blot检测显示:JWYY颗粒可上调PS2并下调PAF的表达,而对照组对胃黏膜PS2和PAF的表达影响不大。结论健胃愈疡颗粒治疗幽门螺杆菌(Hp)相关性胃炎可能与杀灭Hp、上调PS2和下调PAF的表达来抑制细胞凋亡有关。     

2型糖尿病患者一级亲属正常糖代谢人群胰岛素抵抗分析

目的探讨2型糖尿病(T2DM)患者糖耐量正常的一级亲属胰岛β细胞功能及胰岛素抵抗情况,并分析胰岛素抵抗的相关因素。方法选取T2DM患者糖耐量正常的一级亲属63例,根据胰岛素抵抗指数分为胰岛素抵抗组及非抵抗组;选取30例健康体检者作为正常对照组。对所选的93例对象进行血压、血糖、胰岛素、血脂的测定,并计算稳态模型胰岛素抵抗指数(HOMA-IR)及胰岛β细胞功能指数(HOMA-β)。结果①糖尿病患者一级亲属组与对照组相比,胰岛素水平、HOMA-IR、HOMA-β明显升高(P<0.05);②胰岛素抵抗组体质指数、舒张压、甘油三酯、餐后血糖、HOMA-β明显高于胰岛素非抵抗组(P<0.05);③相关分析示胰岛素抵抗与体质指数、舒张压、甘油三酯、餐后胰岛素呈正相关(P<0.01,P<0.05),与空腹血糖、餐后血糖、空腹胰岛素、收缩压、胆固醇无显著相关性(P>0.05)。结论T2DM患者一级亲属存在胰岛β细胞代偿性的高分泌,早期已经出现胰岛素敏感性的下降和胰岛素抵抗。胰岛素抵抗与体重增加、舒张压升高及甘油三酯的升高有关。提示对糖尿病患者一级亲属应严格控制体重、血压及血脂,对减少T2DM具有积极意义。     

EGFR、Ku70、NF-κB及Bcl-2在Graves病中的表达及意义

目的研究Graves病患者细针穿刺组织中EGFR、Ku70、NF-κB和Bcl-2基因的表达水平,探讨其在Graves病发生发展中的作用。方法 Graves病组患者59例,平均年龄(44.66+12.94)岁,其中男16例,女43例;甲状腺结节周围正常甲状腺组织标本27例为对照组,平均年龄(44.64+14.27)岁,其中男6例,女21例。采用实时荧光定量逆转录-多聚酶链反应(RT-PCR)法检测EGFR、Ku70、NF-κB和Bcl-2在Graves病及对照组甲状腺组织中的表达,t检验分析基因表达水平差异;Pearson相关法分析基因表达与临床特征及相关血清学指标之间的关系。结果上述基因在对照组及Graves病甲状腺组织中都有不同程度的表达。Graves病患者组织中EGFR及Ku70的表达水平明显高于对照组甲状腺组织(1.752±0.660 vs.0.859±0.125,P<0.05;3.304±0.402 vs.0.768±0.102,P<0.001);NF-κB及Bcl-2的表达水平明显低于对照组甲状腺组织(0.578±0.066 vs.0.884±0.085,P<0.001;0.834±0.086vs.1.235±0.261,P<0.05)。Graves病组织中NF-κB与Bcl-2表达水平呈正相关(r=0.399,P<0.001)。Graves病组织中Ku70的表达水平与血清TgAb水平呈正相关(r=0.263,P<0.05),而其他基因表达与相关血清学指标无关(P均>0.05)。结论 Ku70、EGFR、NF-κB、Bcl-2介导的信号转导通路可能参与了Graves病的发生、发展过程。