面向模具制造企业的CAD/CAE/CAM集成模型研究

本文分析了模具制造企业的实际，对汽车覆盖件模具CAD/CAE/CAM集成系统的关键技术、运行模式等进行了理论探讨性研究，并给出了模具制造企业CAD/CAE/CAM一体化系统集成的部分模型描述。     

小细胞肺癌及其配对的正常肺组织差异表达蛋白质的双相电泳-飞行时间质谱研究

目的应用比较蛋白质组学方法分析小细胞肺癌(SCLC)与其配对的正常肺组织差异表达蛋白质,为阐明SCLC发病机制、筛选其早期诊断标志物提供有益的思路。方法应用双相电泳(2-DE)分离6例SCLC及其配对的正常肺组织可溶性总蛋白;应用基质辅助激光解吸电离飞行时间质谱(MALDI-TOF-MS)获得差异蛋白点的肽质量指纹图谱(PMF);通过Mascot软件查询NCBI或SWISS-PROT数据库鉴定蛋白质。结果每张图谱约检测到800多个蛋白质点。经匹配分析,肺癌组织之间和正常肺组织之间凝胶图像的匹配率分别为75.5%和78.2%;选择14个背景清晰、重复性及分辨率较好、蛋白表达差异明显的点进行质谱分析,结合表观分子量及等电点(pI),初步鉴定了11种(六类)蛋白质:①与蛋白质降解通路有关的蛋白质:蛋白酶体α亚单位3型、蛋白酶体β亚单位2型及β亚单位5型;②自由基/抗氧化剂类:锰-超氧化物歧化酶(Mn-SOD)、过氧化氢酶(CAT)和黄素还原酶(FR);③细胞骨架类:原肌球蛋白-3(Tpm-3);④与能量代谢有关的蛋白质:硫氧还蛋白过氧化物酶(TPX1);⑤分子伴侣:抑制素(PHB),内质网蛋白ER29(Erp29);⑥其他:可溶性NSF黏附蛋白(alpha SNAP)。结论应用2-DE及MALDI-TOF-MS方法分离并初步鉴定了11种(六类)蛋白质;这些蛋白质与SCLC发生发展密切相关,部分可能成为SCLC诊断及治疗的分子靶点。     

History of wheel/rail contact mechanics: from Redtenbacher to Kalker

The history of wheel/rail contact mechanics is an integrated part of contact mechanics. Problems of wheel/rail contact (damage phenomena and influence of contact mechanics on vehicle dynamics, especially on vehicle stability) have been investigated since the middle of the 19th Century. In 1855, Redtenbacher was the first to consider head checking. Stability investigations started with Boedecker (1887) and were continued by Carter (1916); however, they were not recognized at that time. Stability analysis was only considered to be an integrated step in vehicle design in about 1955 when stability problems started to occur in practice. The scientific foundations of our present investigations are based on Heinrich Hertz, Frederick William Carter and Hans Fromm. The key contributors to research in the last fifty years in the field of wheel/rail contact mechanics are Joost Kalker and Ken Johnson.     

Intelligent drug delivery system using UML diagrams analysis

A novel intelligent drug delivery system potential for the more effective therapy of the diabeticswas proposed, and the composition of system was analyzed. Based on the design of micro-electro-mechanicalsystems (MEMS), an iterative modeling process was introduced. Unified modeling language (UML) was em-ployed to describe the function requirement, and different diagrams were built up to explore the static model,the dynamic model and the employment model. The mapping analysis of different diagrams can simply verifythe consistency and completeness of the system model.     

基于Pro/E塑料顾问分析的塑料盒盖注射模具设计

针对传统模具设计的弊端,提出了采用模流分析技术对模具进行优化设计的思想。以Pro/E塑料顾问为平台,以塑料盒盖零件为实例,对其浇口位置进行计算机模拟分析,并在此基础上对塑料产品进行注射成型工艺模拟分析。综合分析结果有针对性地优化模具设计方案,避免了设计中的盲目性,提高了塑料产品的成型质量,减少了缺陷的产生,降低了生产成本,缩短了生产周期。     

基于组合校正的城市轨道交通列车轮轨黏着控制方法研究

为提高城市轨道交通列车轮轨黏着力的控制,针对传统组合校正法存在的缺点,对参考速度进行延时补偿、筛选及步长限制,尽可能保证参考速度的准确性;对加速度提取采用低通加高通滤波器的方法,以降低噪声影响;黏着控制过程中,根据设定周期时间内速度差估算当前轨面黏着情况,实时调整下一周期判据阈值;根据上一调节周期触发空转时刻锁存转矩和当前加速度,以及转速差采用分段斜率的方法进行转矩调节。试验结果表明:上述控制方法转矩波动小,列车运行平稳,黏着利用率得到有效提高。     

FOB条件下进口商指定货代无单放货的风险防范

FOB术语的优点在于核算报价简单,工作量较小,不需要太多的国际贸易知识和经验,但是FOB交易条件下,由买家租船订舱,对于买家来说,他们更信任关系密切合作多的货代而不是卖方,所以他们会指定他们自己合作的货代发货,货代因为被买家指定而为了更好的服务买家会对买家言听计从,包括放货,所以FOB条件存在着致命的缺陷,那就是——钱货两空.如何规避FOB术语下买方指定货代的风险？本文将着重进行这方面的探讨.     

Assessing social equity in distance based transit fares using a model of travel behavior

The goal of this study is to develop and apply a new method for assessing social equity impacts of distance-based public transit fares. Shifting to a distance-based fare structure can disproportionately favor or penalize different subgroups of a population based on variations in settlement patterns, travel needs, and most importantly, transit use. According to federal law, such disparities must be evaluated by the transit agency, but the area-based techniques identified by the Federal Transit Authority for assessing discrimination fail to account for disparities in distances travelled by transit users. This means that transit agencies currently lack guidelines for assessing the social equity impacts of replacing flat fare with distance-based fare structures. Our solution is to incorporate a joint ordinal/continuous model of trip generation and distance travelled into a GIS Decision Support System. The system enables a transit planner to visualize and compare distance travelled and transit-cost maps for different population profiles and fare structures. We apply the method to a case study in the Wasatch Front, Utah, where the Utah Transit Authority is exploring a switch to a distance-based fare structure. The analysis reveals that overall distance-based fares benefit low-income, elderly, and non-white populations. However, the effect is geographically uneven, and may be negative for members of these groups living on the urban fringe.     

客车品牌整合营销传播中的项目管理应用研究

将项目管理的思想引入到客车行业的品牌整合营销传播之中,重点分析研究客车品牌整合传播中的进度控制和成本管理,以提高客车品牌营销的管理水平和传播效果。