盐渍土的工程性质及其施工技术

结合盐渍土的形成及工程性质,分析盐渍土地区道路路基的病害特征,研究表明,盐渍土的特殊工程性质易造成路基溶陷、翻浆和次生盐溃土等病害,并从路基填料、含水量控制、路基压实和排水等方面提出盐渍土地区道路路基的施工技术及施工注意事项。     

改性乳化沥青纤维同步碎石封层技术的应用

改性乳化沥青纤维具有良好的抗滑性能和防水性能,有效地延长了道路的使用寿命.鉴于此,结合工程实例,详细地阐述了某公路项目出现的病害,同时探讨病害处理方法,并提出采取改性乳化沥青纤维同步碎石封层技术对公路进行预防性养护,以提高路面处理效果.     

黄石高速公路路面技术状况检测评价

依据公路养护规范,对黄石高速公路路面的病害进行检查,并对其综合技术状况进行评定,指出该线路面整体技术状况指数表现优良,局部路段路面病害相对较多.这可为相关方确定养护方案提供参考.     

海南地区高速公路沥青路面改建关键技术应用研究

以海南西线高速公路路面改建工程为依托,介绍了海南地区高速公路路面改建关键技术。面层以下基层以及土基的检测与判别、基层病害处治以及原沥青路面再生回收利用是沥青路面改建的关键技术。FWD弯沉盆数据D20-D60指标可以作为基层松散的判定指标,PSSI指数小于53时,需要对路基进行处治。泡沫沥青厂拌冷再生较适合海南地区路面再生回收利用方案。     

AQP4在COPD支气管黏膜的表达及其与患者肺功能、气道黏膜炎症的相关性

目的通过免疫组化法检测支气管黏膜中水通道蛋白-4(aquaporin-4,AQP4)的表达,观察正常组和慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)组支气管黏膜中AQP4表达与气道黏膜炎症及肺功能的关系,明确AQP4在COPD发生、发展中的作用,为COPD的防治开辟新途径。方法选择正常人和COPD患者各30例,测试肺功能,并行支气管镜检查,取得支气管黏膜标本,用免疫组化法检测AQP4表达,HE染色观察支气管黏膜炎症细胞浸润程度。结果COPD组较对照组AQP4表达减弱有极显著差异(P<0.001)。AQP4表达和FEV1/FVC、FEV1/pred%呈正相关(P<0.001),与支气管黏膜炎症严重程度呈负相关(P<0.001)。结论COPD患者AQP4表达减少可能是其肺功能下降及气道炎症加重的原因之一。临床上可以通过改善AQP4治疗COPD。     

The changes of neuronal activity of the zone incerta in a rodent model of Parkinson＇s disease

Objective To study the changes in neuronal activity of the zone incerta (ZI) following the unilateral lesion of the nigrostriatal pathway. Methods Eiectrophysiological recordings of ZI neurons were made in normal rats and in two groups of rats at different time intervals after injection of 6-hydrodopamine (6-OHDA) into the pars compacta of snbstantia nigra by extracellular recording in vivo. Results The results showed a significant increase in the mean firing rate of ZI during the second and fourth weeks after 6-OHDA lesion [-n=32, (3.6±2. 2)Hz, P<0.001; n=35, (9.3±6.6)Hz, P<0. 001, respectively] compared to that of normal rats [n=39, (9.2±5.2)Hz]. However, no significant change was observed between two groups of 6-OHDA-lesioned rats. With regard to firing pattern, 7.7%(3/39) of ZI neurons discharged regularly, 82.1% (32/39) irregularly and 10. 3% (4/39) in bursts in normal rats. During the second week after 6-OHDA lesion, the regular, irregular and bursting firing neurons recorded in the ZI were 9.4% (3/32), 59. 4% (19/32) and 31.3% (10/32), and during fourth week, the regular, irregular and bursting firing neurons were 14.3% (5/35), 57.1% (20/35) and 28. 6% (10/35), respectively. The firing pattern of the neurons in the three different groups did not change significantly. Conclusion These results suggest that the firing rate of ZI neurons in 6-OHDA-lesioned rats is increased significantly, which may contribute to the pathophysiology of Parkinson's disease.     

Study on T lymphocyte subsets and NK cells in patients with Graves＇ disease combined with type 2 diabetes

Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM.     

高速公路水泥混凝土路面质量问题探讨

当前水泥混凝土路面在高速公路建设中的应用比较普遍,就其在施工和养护中出现的各种病害、裂缝产生的过程,混凝土原材料、配合比、水灰比、施工操作等对质量的影响,以及产生外观质量缺陷的原因进行了比较全面的评述。     

上皮型钙粘附蛋白和层粘连蛋白在妊娠滋养细胞疾病中的表达及意义

目的探讨上皮型钙粘附蛋白(E-cad)和层粘连蛋白(LN)在妊娠滋养细胞疾病(GTD)中的表达及意义。方法应用免疫组织化学(SP法)检测74例GTD中E-cad和LN的表达情况。结果在GTD中,E-cad的正常表达率和LN强表达率分别为37.8%(28/74)和64.86%(48/74),显著低于正常绒毛组织。在葡萄胎(HM)、侵蚀性葡萄胎(IM)及绒毛膜癌(CC)中E-cad的正常表达率分别为53.3%、31.25%和16.67%;LN的强表达率分别为80%、56.25%和50%。随着GTD恶性程度的增加,E-cad的正常表达率及LN的强表达率逐渐降低,且与正常绒毛组织有显著差异。结论E-cad及LN的表达与GTD的发生、恶变及侵袭有关系;对E-cad与LN表达的监测有助于预测GTD的发展趋势及提示治疗效果。     

新疆盐渍土路基设计探讨

通过分析盐渍土的工程性质及其对公路路基的病害类型,论述盐渍土地区道路设计中需要考虑的一些问题,并提出相应的对策,以满足盐渍土地区路基设计要求,保证道路的安全及可靠.