2型糖尿病患者一级亲属正常糖代谢人群胰岛素抵抗分析

目的探讨2型糖尿病(T2DM)患者糖耐量正常的一级亲属胰岛β细胞功能及胰岛素抵抗情况,并分析胰岛素抵抗的相关因素。方法选取T2DM患者糖耐量正常的一级亲属63例,根据胰岛素抵抗指数分为胰岛素抵抗组及非抵抗组;选取30例健康体检者作为正常对照组。对所选的93例对象进行血压、血糖、胰岛素、血脂的测定,并计算稳态模型胰岛素抵抗指数(HOMA-IR)及胰岛β细胞功能指数(HOMA-β)。结果①糖尿病患者一级亲属组与对照组相比,胰岛素水平、HOMA-IR、HOMA-β明显升高(P<0.05);②胰岛素抵抗组体质指数、舒张压、甘油三酯、餐后血糖、HOMA-β明显高于胰岛素非抵抗组(P<0.05);③相关分析示胰岛素抵抗与体质指数、舒张压、甘油三酯、餐后胰岛素呈正相关(P<0.01,P<0.05),与空腹血糖、餐后血糖、空腹胰岛素、收缩压、胆固醇无显著相关性(P>0.05)。结论T2DM患者一级亲属存在胰岛β细胞代偿性的高分泌,早期已经出现胰岛素敏感性的下降和胰岛素抵抗。胰岛素抵抗与体重增加、舒张压升高及甘油三酯的升高有关。提示对糖尿病患者一级亲属应严格控制体重、血压及血脂,对减少T2DM具有积极意义。     

饲料加硼对摄入过量氟的实验大鼠骨损伤的预防作用

目的探讨饲料加硼对过量氟摄入的大鼠骨损伤的预防作用。方法24只4-5周龄Sprague-Dawley(SD)大鼠分为:对照组(喂饲基础饲料,饮蒸馏水)、过量氟组[喂饲基础饲料,饮含100mg/LF-(氟化钠221mg/L的蒸馏水)]、硼预防组(喂饲加硼饲料,饮含100mg/LF-的蒸馏水)。实验3月后测量大鼠血清氟、硼含量及血清碱性磷酸酶(alkaline phosphatase,AKP)活性、骨氟和骨总RNA含量、胫骨纵径横径和干重及骨密度(bone mineral density,BMD),并检测大鼠股骨生物力学特性。结果和对照组比较,过量氟组大鼠血清氟、骨氟含量和血清AKP活性显著增高;骨总RNA含量、全身骨骼平均BMD和胫骨BMD降低;胫骨纵径、横径和干重减小;股骨最大负荷减低,最大形变增加。相比过量氟组,硼预防组大鼠血清氟和骨氟含量及AKP活性明显下降;骨总RNA含量、全身骨骼平均BMD、腰椎和胫骨BMD显著增高;胫骨纵径、横径和干重,股骨最大负荷明显增加。3组大鼠血清硼含量无显著性差异。结论大鼠摄入过量氟可出现明显的骨损伤,饲料加硼对此有一定的预防作用。     

广义Kantorovich不等式的范数改进及其统计应用

对于广义Kantorovich不等式,选用适当的矩阵度量并给出相应的界,可以应用在线性模型的参数估计的相对效率问题上。用谱范数作为度量工具,给出广义Kantorovich不等式的的上界改进,并将其应用在线性模型中最小二乘估计的相对效率问题上。     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

密级配沥青混合料AC-10C的适宜压实厚度试验研究

通过对铺筑厚度为20mm～60mm的密级配沥青混合料AC—10C常用施工工艺的分析,建立现场取芯试件空隙率和路面厚度的关系,并得出空隙率随厚度而变化的规律,对修订我国施工规范推荐的压实适宜厚度提出了试验依据。     

基于人工神经网络的湘江最大洪峰流量中、长期预报

将统计相关性分析与模糊方法相结合,识别出影响湘江湘潭站年最大洪峰流量的前期流域降水、大气环流形势等预报因子,通过比较几种改进的BP网络的优缺点,探讨了BP网络建模过程中存在的几个问题,建立了LMBP算法和自适应BP算法相耦合的神经网络中、长期水文预报模型．预报结果表明：预报效果好、精度高,且具有较高的推广和应用价值．     

A total generalized optimal velocity model and its numerical tests

A car-following model named total generalized optimal velocity model （TGOVM） was developed with a consideration of an arbitrary number of preceding vehicles before current one based on analyzing the previous models such as optimal velocity model （OVM）, generalized OVM （GOVM） and improved GOVM （IGOVM）. This model describes the physical phenomena of traffic flow more exactly and realistically than previous models. Also the performance of this model was checked out by simulating the acceleration and deceleration process for a small delay time. On a single circular lane, the evolution of the traffic congestion was studied for a different number of headways and relative velocities of the preceding vehicles being taken into account. The simulation results show that TGOVM is reasonable and correct.     

特立尼达湖沥青灰分的试验分析

对TLA灰分和两种对比矿粉的密度、颗粒组成、比表面积、扫描电镜以及X衍射等试验进行分析.分析结果表明,TLA灰分的密度和比表面积明显大于两种对比矿粉的密度和比表面积;TLA灰分的主要成分为硅酸盐火山灰细粉,其粒径最细、分布均匀,表面粗糙、形状不规则,而两种对比矿粉颗粒较粗,分布不均匀,表面光滑、棱角分明.因此,TLA灰分具有很强的吸附作用,对提高TLA改性沥青的性能起着重要的增劲作用.     

Modeling Feedback Scheme of Empty Cars in Unloading End of Heavy Haul Railway

The transportation organization of heavy haul railway is complex in China, especially, the feedback of empty cars. On the basis of reference to the existing research results, and deep analysis of the characteristics of empty cars distribution of heavy haul railway, the authors construct the feedback schematic model of empty cars in unloading end of heavy haul railway. The minimum quantity of the combined trains and the time for combination is taken as the model goal and solution algorithm on the basis of minimum cost and maximum flow is formulated. Daqin railway is taken as an example and relevant conclusions of feedback scheme of empty cars of heavy haul railway, through an analysis of calculation results, are drawn.     

关联效应对CaCuO2的电荷与自旋密度分布的影响

采用杂化密度泛函方法和哈垂一福克方法对CaCuO2的电荷与自旋密度的分布进行了研究．CuO2层的电子结构具有明显的二维特征．电子间的关联效应使Cu离子的自旋极化被削弱的同时，增强了O离子的自旋极化效应．