亚硒酸钠对小鼠脾细胞DNA合成的影响

本文通过1次和多次给小鼠不同剂量的亚硒酸钠,以~3H-TdR掺入脾细胞DNA为指标,同时进行全血硒浓度测定,观察了补硒对小鼠体内细胞DNA合成的影响以及与血硒浓度的关系。结果表明:①亚硒酸钠对脾细胞DNA合成呈双相作用,低剂量促进其合成,高剂量则产生毒性抑制作用,毒性作用短暂、可逆,与1次大剂量有关。②多次给硒,最终血硒浓度与毒性作用之间不呈正相关。③补硒的单次剂量和方式影响稳态血硒浓度水平。     

OBSERVATION OF THE EFFECT OF S－（－）USNIC ACID SODIUM ON TRICHOMONAS VAGINALIS BY TRANSMISSION ELECTRON MICROSCOPE

ＯＢＳＥＲＶＡＴＩＯＮＯＦＴＨＥＥＦＦＥＣＴＯＦＳ－（－）ＵＳＮＩＣＡＣＩＤＳＯＤＩＵＭＯＮＴＲＩＣＨＯＭＯＮＡＳＶＡＧＩＮＡＬＩＳＢＹＴＲＡＮＳＭＩＳＳＩＯＮＥＬＥＣＴＲＯＮＭＩＣＲＯＳＣＯＰＥＷｕＪｉｅ；ＺｈａｎｇＭｉｎｒｕ；ＤｉｎｇＤｏｎｇｎｉ...     

国产透明质酸钠治疗膝关节退行性关节病的对照研究

目的　通过临床随机对照研究检验国产透明质酸钠治疗膝关节退行性关节病的效果及不良反应 ,为该病治疗寻找新的途径。方法　应用临床随机对照方法将患者分成治疗组与对照组 ,治疗组应用透明质酸钠 ,对照组应用醋酸强的松龙 ,均行膝关节腔注射 ,每周 1次 ,每次剂量分别为 2 0mg和 75mg ,5次为一个疗程 ,治疗前、后观察临床症状及检测关节滑液中白细胞介素 6 (IL 6 )水平及蛋白总量的变化。结果　两种药物均可有效缓解膝关节退行性关节病的临床症状 ,治疗组显效率 5 2 .78% ,有效率 4 4 .4 4 % ,无效率 2 .86 % ;对照组显效率 39.2 9% ,有效率 4 2 .86 % ,无效率 17.86 %。两种药物均可显著降低关节滑液内IL 6的含量 ,但治疗组降低幅度更大。结论　应用透明质酸钠治疗膝关节退行性关节病疗效明显 ,无严重不良反应。     

具有液晶相的四烷氧基苯并菲-1,4-二醌的合成

研究合成了 6,7,10,11-四戊氧基苯并菲-1,4-二醌和 6,7,10,11-四庚氧基苯并菲-1,4- 二醌两个新化合物,经核磁氢谱和碳谱、质谱、IR 及元素分析等测定,对其结构进行了表征。该类化合物在紫外可见光区 250～630 nm 的范围有光吸收。采用偏光显微镜和示差扫描量热仪对其性能进行了研究,结果表明,该材料具有液晶性。此外,本文对该类化合物的合成方法也进行了改进,利用亚硝酸钠/三氟乙酸/二氯甲烷体系替代了常用的硝酸铈铵/四氢呋喃/水体系,反应时间可从原来的 2 h 缩短至 15 min,并在室温下完成;在合成中间体 1,2-二甲氧基-6,7,10,11-四烷氧基苯并菲时,采用二氯甲烷作为溶剂,将三氯化铁与 3,3＇,4,4＇-四烷氧基联苯的摩尔比从 8∶ 1 提高到 10∶1,反应时间可从原来的 5 h 缩短至 2 h。     

海底隧道注浆材料试验研究及工程应用

通过试验分析了普通硅酸盐水泥—水玻璃和矿渣硅酸盐水泥—水玻璃浆液的基本性能。利用正交试验设计方法,以抗压强度为主要指标,对浆液的配比进行了优化设计。通过对两种浆液材料同龄期试块抗压强度的对比发现,矿渣硅酸盐水泥的抗海水腐蚀性能明显好于普通硅酸盐水泥。将优化配比后的浆液用于青岛胶州湾服务隧道地表注浆加固,收到了良好的效果。     

岸桥照明采用LED光源的可行性研究

LED普通照明技术发展较快,LV-LED灯具突破了散热技术瓶颈,HV-LED芯片采用高电压低电流技术,降低了热量,提高了光效。采用LV-LED芯片的400WLED灯和HV-LED芯片的300WLED灯与在用岸桥所采用的1000W高压钠灯相比,在初投资、节能、环保方面,LED灯有优势。     

武广客运专线边坡支护结构中锚固体抗腐蚀性的技术措施

针对边坡支护结构中锚固体腐蚀是引起结构破坏失效的重要因素,其主要表现为锚固用水泥砂浆灌浆不足、浆体自干燥收缩裂缝大、抗环境水侵蚀能力差等方面。以武广客运专线为研究背景,针对锚固体易出现的腐蚀情况和特点设计试验,考察锚固用水泥砂浆的流动性、匀质性、自收缩性能及抗硫酸盐侵蚀性能等因素,提出改善锚固体抗腐蚀性能的技术措施。结果表明:粉煤灰、矿渣等矿物掺合料和新型外加剂KS-Ⅰ能够有效提高水泥砂浆的工作性能和抗侵蚀能力,满足工程应用的需要。试验结果为武广客运专线锚固结构防腐设计提供了依据,并可为类似设计提供技术储备。     

Biogeochemistry of sulfur in a sediment core from the west-central Baltic Sea: Evidence from stable isotopes and pyrite textures

The biogeochemistry of the sulfur cycle in a ca. 5-m-long sediment core from the eastern slope (221 m water depth) of the Landsort Deep in the west-central Baltic Sea was investigated by analyzing the solid phase records of sulfur isotopes and pyrite textures, besides selected main and minor elements. The sediments were deposited during post-glacial history of the Baltic Sea when the basin experienced alteration of brackish (Yoldia Sea, Littorina Sea) and freshwater (Baltic Ice Lake, Ancylus Lake) conditions. The stable isotopic composition of total sulfur was analyzed as a function of depth. In selected samples pyrite (FeS₂), greigite (Fe₃S₄), and barite (BaSO₄) fractions were separated for isotope analyses. Pyrite textures were analyzed by SEM and optical microscopy.Microbial reactions associated with the oxidation of organic matter resulted in assemblages of authigenic sulfide minerals which for the post-Ancylus Lake brackish water environment are dominated by pyrite and for freshwater environments by Fe-monosulfides. The sulfur isotopic composition of the brackish water Littorina Sea sediments (δ³⁴S between −40 and −27‰ vs. V-CDT) is believed to be determined by cellular sulfate reduction rates and reactions involving intermediate sulfur species. The availability of reactive iron and decomposable organic matter as well as sedimentation rate and the chemocline position are important variables upon the δ³⁴S values of sulfides in brackish water environment. The syn-depositional abundance of sulfur and organic matter, and transport of dissolved sulfur species vs. rates of microbial reactions determine δ³⁴S in the freshwater sediments. The upper part of the Ancylus Lake sediments is sulfidized by downward diffusing H₂S and/or sulfate from overlying brackish water sediments. Minor concretionary barite formation in the freshwater sediments is most likely due to the reaction of pore water sulfate diffusing downward from brackish water sediments with barium desorbed from freshwater sediments. The size distribution of pyrite framboids in the brackish sediments indicates that the formation mainly occurred from anoxic pore waters, although some pyrite formation in an anoxic water column cannot be excluded.     

A SIX－YEAR RETROSPECTIVE STUDY ON THE RELATIONSHIP OF SODIUM－LITHIUM COUNTERTRANSPORT WITH BLOOD PRESSURE AND SODIUM SENSITIV

ＡＳＩＸ－ＹＥＡＲＲＥＴＲＯＳＰＥＣＴＩＶＥＳＴＵＤＹＯＮＴＨＥＲＥＬＡＴＩＯＮＳＨＩＰＯＦＳＯＤＩＵＭ－ＬＩＴＨＩＵＭＣＯＵＮＴＥＲＴＲＡＮＳＰＯＲＴＷＩＴＨＢＬＯＯＤＰＲＥＳＳＵＲＥＡＮＤＳＯＤＩＵＭＳＥＮＳＩＴＩＶＩＴＹＩＮＣＨＩＬＤＲＥＮ（牟...     

成年大鼠脑组织蛋白聚糖的提取与分离

本文以成年大鼠脑组织为实验对象，应用层析、酶解及电泳技术对３种提取方法２种提取剂提取蛋白聚糖的效果进行分析比较。结果表明：①用４ｍｏｌ／Ｌ盐酸胍提取脑蛋白聚糖的量均显著高于用ＰＢＳ，其蛋白质与蛋白聚糖之比却均低于ＰＢＳ．②ＰＢＳ能提取脑组织中的可溶性蛋白聚糖，４ｍｏｌ／Ｌ盐酸胍既能提取脑组织中的可溶性蛋白聚糖也能提取难溶性蛋白聚糖。③脱脂处理能降低脑蛋白聚糖的提取率，④脑蛋白聚糖经ＰＢＳ提取后，再经４ｍｏｌ／Ｌ盐酸胍提取，沉淀物中其含量甚微。