表面状态对60Si2CrVAT弹簧钢疲劳性能的影响

对表面脱碳与喷丸状态不同的60Si2CrVAT弹簧钢进行了疲劳性能对比试验,结果表明:860℃-50min加热,试样表层形成约0.1mm的脱碳层,但未观察到对疲劳寿命产生明显影响;适度喷丸在试样表层形成压应力使疲劳寿命大大提高;过度喷丸虽使表面粗糙度减小,但使表层材料受到损伤,因此疲劳寿命平均值降低.     

Role of candesartan against cerebral ischemia and oxidative damage in normotensive rats

Objective Angiotensin Ⅱ (Ang Ⅱ ) contributes to modulating blood pressure by stimulation of Ang Ⅱ AT1 receptors. We devised a rat transient middle cerebral artery occlusion (MCAO) model to assess whether oxidative damage is decreased after pretreatment with Angiotensin Ⅱ AT1 receptor blocker (ARB). Methods After 2 weeks pretreatment with ARB 0. 5 and 1 mg/kg, the male Wister rats were subjected to 2 h middle cerebral artery occlusion (MCAO). At 24 h, the lumen diameter of middle cerebral artery, the plasma level of 8-hydroxy-2'-deoxyguanosine (8-OHdG), and HIF-1 a levels were recorded and compared. Results After pretrcatment with ARB 0.5 and 1 mg/kg, blood pressure did not significantly change compared with that of controls. In the group of candesartan at 1 mg/(kg· day), the lumen diameter was significantly increased compared to that in control group [(86.0±5.0) μm vs. (69.0± 2.1) μm; P<0. 01, n = 6- 8]. The plasma 8-OHdG levels of ARB pretreatment groups were decreased. In immunohistochemical findings, 8-OHdG- and HIF-1α-containing cells in ARB pretreatment groups were decreased. Conclusion Brain ischemia and oxidative damage can be reversed by AT1 receptor blockade in normotensive rats after transient cerebral artery occlusion.     

混凝土梁损伤识别的试验研究

由于目前基于桥梁动力信息的损伤识别方法存在不少问题,本文尝试性地采用结构自重作为损伤识别分析的外部信息,在此基础上分析混凝土裂缝损伤对结构的哪些响应变量有重要影响,以及影响的性质有什么不同,从而找到能较好的反映结构损伤的物理量。通过光纤传感器和传统电测应变片的对比试验,验证了光纤传感器用于损伤识别的可行性。     

基于ANSYS实体模型对小跨径钢筋混凝土简支梁旧桥的模态分析

基于ANSYS实体模型,介绍宽跨比大于1,桥面连续的小跨径简支梁旧桥实体模型的建模要点,说明材料本构关系的选择方法.对比现场动载试验,分析桥梁结构损伤对动力特性的影响,重点分析梁体法向裂缝的影响因素,并详细介绍运用ANSYS实体模型模拟、分析梁体法向裂缝的方法.以现场实测桥梁为例,进一步研究上述方法的工程可行性.     

钢筋混凝土桥梁检测与损伤评价

当前钢筋混凝土桥梁结构的病害大量出现,需要研究其结构检测与损伤评价的方法,根据评价预测的深度,其目标可分为4个层次.分类综述了桥梁结构检测与损伤评价的方法体系,分析了其存在的主要问题和提出了以后的发展重点.     

褪黑素对低硒饲料大鼠肝脏损伤的影响

目的　研究褪黑素对克山病病区低硒粮喂养的大鼠肝脏损伤的影响及其可能机制。方法　将SD大鼠分为3组 ,分别用低硒饲料、低硒饲料加硒、低硒饲料加褪黑素灌胃饲养 ,观察大鼠体质量增加情况。 12周时检测血Se、血GSH Px活性、肝组织MDA水平及肝组织病理损伤情况。结果　 12周时低硒组大鼠的体质量增加明显低于其他两组 ,血Se、血GSH Px活性较加硒组 (对照组 )显著降低 ,肝组织MDA及光镜下肝脏病变检出率均明显高于其他两组。加硒组与褪黑素组MDA无显著差异 ,光镜下两组均未见肝坏死。结论　褪黑素可预防克山病病区低硒粮引起的大鼠肝脏损伤 ,其保护作用可能与抗氧化机制有关。     

EXPRESSION OF NESTIN AND GLIAL FIBRILLARY ACIDIC PROTEIN IN DIFFERENT PERIOD AFTER SPINAL INJURY IN ADULT RATS

Objective To study the expression of Nestin and glial fibrillary acidic protein (GFAP) in different period after spinal injury in adult rats. Methods Animal moels were created by artery clamp. Expression of Nestin and GFAP in different period ( 1,3,5days; 1-8 weeks) and different area( injury locus and its surrounding tissue ) after spinal injury were observed pathologicaly using immunofluorescence and LeicaQ5001W imaging processing system.Results There was expression of Nestin and GFAP in injured area 1 day after injury. The expression increased not only in in injured area but its sourrounding 3--7 days later and gradually got to peak value. As the time went on, expression of Nestin and GFAP dereased. Conclusion Spinal injury can induce the expression of Nestin. Nerve stem cell has response to spinal injury. There is positive correlation between expression of Nestin and hyperplasia of reactivity astrocyte. Nerve stem cell maybe invovled in the repair of central nervous system (CNS).     

船舶疲劳强度校核分析

船体结构因磨损、裂纹等缺陷，导致疲劳强度不足，引发重大事故，为此从保障航运生产安全的实际要求出发，对基于S-N曲线校核船舶疲劳强度的原理给出了详细的说明。     

沥青混合料有效温度的计算和应用

笔者从沥青路面的疲劳开裂和车辙两大病害出发，分析了温度对沥青混合料和沥青路面设计的影响，并以沥青混合料疲劳和车辙试验为基础，以陕西省的气候温度状况为例，按照损伤等效原则计算出陕西省典型地区的沥青路面疲劳和车辙有效温度，为沥青路面设计提供参考．     

箱涵裂缝形成机理的三维损伤有限元分析（2）

笔者尝试实现损伤理论有限元的结合(损伤有限元)，并运用于对整体结构的损伤进行分析衡量、为此，以应变为损伤变量定义了新的内变量-损伤度，并在此基础上修正了J．Mazars的本构方程建立新的损伤本构方程．进而形成一种用于结构整体的强度校核方法．将这一方法运用于重庆市沙滨路排污管道试验段砼箱涵的裂缝形成的损伤机理分析和强度校核，实践证明是可行的、本方法的发展对损伤力学运用于工程实际具有重要意义．