常规公交引导TOD模式的应用——以蓬莱市为例

传统TOD模式提供了一条土地与交通协调发展的有效途径,我国很多大城市结合自身情况在规划中引进TOD理念,取得了成功的实践经验。对于正在蓬勃发展的小城市,应当建立常规公交引导的TOD模式,作为可持续发展的重要手段。     

新型胫骨动力加压交锁髓内钉治疗不稳定骨折的力学性能分析

目的 研制具备动力加压功能的新型胫骨交锁髓内钉,并分析其在胫骨不稳定骨折治疗中的可行性及力学性能.方法 男性健康成人防腐尸骨胫骨湿标本45根,随机分左右侧进入不同实验组,按骨折髓内钉及加压钢板内固定的标准手术操作进行内固定后,于胫骨结节上缘至踝关节平面连线中点锯断,制成骨折端间隙环形扩大至5 mm的不稳定骨折模型.新型髓内钉组:新型胫骨髓内钉25套,直径8 mm,长度280 mm.对照组:分为进口髓内钉对照组及AO加压钢板对照组,其中髓内钉对照组为orthofix胫骨髓内钉10套,规格与实验组相同;胫骨8孔AO加压钢板10套为钢板对照组.各组分别进行轴向压缩试验、三点弯曲试验及扭转试验,对不稳定骨折模型的不同内固定方式的抗轴向压缩、抗侧弯、抗旋转力学性能进行测试比较.结果 不稳定骨折情况下,钢板对照组的抗轴向压缩能力最差,新型髓内钉组的抗短缩能力不及髓内钉对照组,组间差异有统计意义(P<0.01).新型髓内钉组的抗侧弯稳定性明显优于髓内钉对照组,3组中钢板对照组抗侧弯性能最优,组间差异有统计意义(P<0.05).随骨折稳定性的下降各组抗扭转性能均有不同程度下降.新型髓内钉组的抗扭转性能次于钢板对照组而优于髓内钉对照组(P<0.05).结论 新型髓内钉的综合力学性能具有明显优越性,其力学性能可保证骨折端的复位和固定要求.     

Relationship between the acid-suppression efficacy of proton pump inhibitors and CYP2C19 genetic polymorphism in patients with peptic ulcer

Obiective To investigate acid-suppression efficacy of proton pump inhibitors(PPls) in relation to CYP2C19 genetic polymorphism on patients with peptic ulcer. Methods By an open, randomized and control trial, fifty nine patients with active peptic ulcer were randomly assigned to receive one of three PPIs on a single dose (20 mg of each drug): omeprazole group (n=19), rabeprazole group (n=20) and esomeprazole group (n=20). lntragastric pH was recorded 1 hour before and 24 hours after administration. CYP2C19 genotype was tested in all patients. Resuits The EMs/PMs ratio of each group was 16/3,17/3 and 17/3, respectively. The total time that intragastric pH＞4, time percent pH＞4 and median pH in PMs patients were significantly higher than those in EMs patients of omeprazole group (P＜0.05). But all these differences were not found in rabeprazole group and esomeprazole group. The pH of nocturnal acid breakthrough (NAB) in both rabeprazole group and esomeprazole group was higher than that of omeprazole group, while there was no significant difference between rabeprazole group and esomeprazole group. Gonclusion The acid-suppression efficacy of omeprazole is highly dependent on CYP2C19 genetic polymorphism, while CYP2C19 genetic polymorphism may have a little influence on the acid-suppression efficacy of rabeprazole and esomeprazole. The acid-suppression action of rabeprazole and esomeprazole is superior to omeprazole, especially on night acid secretion.     

Relationship between the expression of matrix metalloproteinase-9 and angiogenesis in glioma and its clinical significance

Objective To explore the role and significance of matrix metalloproteinase-9 (MMP-9) in angiogenesis through observing the relationship between the expression of MMP-9 and microvessel density (MVD) in glioma. Methods The expressions of MMP-9 and CD34 in 10 cases of normal brain tissues and 58 cases of glioma (14 cases of grade Ⅰ , 20 cases of grade Ⅱ , 15 cases of grade Ⅲ, and 9 cases of grade Ⅳ ) were detected by immunohistochemical streptavidin-peroxidase technique. The positive cells of MMP-9 and the positive microvessels were examined under binocular light microscope. Results The positive expression of MMP-9 in glioma was located in the tumor-cell cytoplast and endothelial cells. The positive rate of MMP-9 in glioma of grade Ⅰ, Ⅱ, Ⅲ and Ⅳ was 42.9%, 65.0%, 86.7% and 88. 9%, respectively. The expression of MMP-9 was obviously higher than that of normal brain tissues (P<0.01) and positively correlated with glioma malignancy (rz =0. 597, P<0.05). MVD was correlated with glioma malignancy (H=47. 865, P<0. 05). The expression of MMP-9 was significantly correlated with MVD (rz =0.897, P<0.01). Conclusion The expressions of MMP-9 and MVD are correlated with glioma malignancy, which may be helpful in judging the malignancy, invasion and prognosis. MMP-9 plays an important role in angiogenesis of glioma and accelerates glioma malignancy development by promoting angiogenesis.     

从供给侧发力,打造泉州幸福公交

近几年,泉州公交贯彻中央供给侧结构性改革思路,在提升运营效率、提升服务水平、提升整体效能、减低综合成本等方面积极探索供给侧结构性改革,取得显著成效。     

物理康复联合小青龙汤治疗儿童哮喘缓解期肺脾气虚证的效果

目的 探讨物理治疗联合中医培土生金法治疗儿童哮喘缓解期肺脾气虚证的效果及对血清学指标的影响。方法 择2018年5月—2020年5月于我院就诊的哮喘缓解期患儿130例,随机分为联合组(n=65)与物理组(n=65),物理组采用物理治疗、孟鲁司特钠咀嚼片治疗,联合组给予物理治疗和基于培土生金法的小青龙汤,两组均治疗3个月。比较两组治疗疗效,治疗前及治疗后胸闷(发作)、咳嗽、气喘、喉间喘鸣主要中医症状积分。记录治疗前(T0)、治疗1、2、3个月后(T1、T2、T3),治疗后第6、9个月随访(T4、T5)中医综合征平均评分。并于治疗前及治疗后采集患儿血清并检测肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、免疫球蛋白E(immunoglobulin, Ig E)、白细胞介素6(interleukin 6,IL-6)水平。结果 治疗后联合组患儿治疗总有效率(86.15%)高于物理组(73.85%)(χ²=4.333,P<0.05)。治疗后气喘、喉间痰鸣的中医证候积分均降低且联合组低于物理组(P<0.05)。T3、T4及T5联合组中医证...     

关于不同人群感染新型冠状病毒的恢复期康复治疗

新型冠状病毒感染(简称新冠感染)患者恢复期仍有多种功能障碍,康复治疗的及时介入对促进患者功能改善及提高日常生活能力具有重要临床意义。本文基于目前循证医学证据及临床实践,对单纯新冠感染患者和既往有功能障碍合并新冠感染者(如神经功能障碍、慢性疼痛、骨关节疾病等)的不同人群在新冠感染恢复期的康复治疗及注意事项进行了归纳总结,以期为新冠感染患者恢复期的康复治疗提供临床参考。     

考虑应激避让行为的自行车轨迹预测

非机动车道空间受限时,常规自行车被超车场景下骑行者为确保自身安全会产生应激避让行为。为明确其在被超车时的应激反应,并根据行为特性设计非机动车道,构建一种面向应激行为分类的自行车轨迹预测模型。该模型从频域角度分解自行车被超车时的动力学特性,依据踏频值范围将避让行为分为匀速、加速和减速行为,利用鲸鱼算法改进长短期记忆神经网络模型,分别对分类后的骑行轨迹进行预测。应用所构建预测模型对西安市2415次超车事件的分析结果显示,发生冲突时选择上述3种避让行为的骑行者占比分别为11.3%、38.3%和50.4%。匀速避让的预测轨迹全程波动较小,平均横向位移为0.15 m;加速避让轨迹表现为横向位移较大,平均达0.83 m;减速行为预测轨迹平缓度介于两者之间,横向位移为0.47 m。3种预测情况下的均方根误差分别为0.0619、0.0513和0.0587,拟合优度值分别为0.9589、0.9774和0.9687。与未考虑应激行为分类的结果相比,所构建模型的预测精度分别提升了11.07%、13.22%和12.21%。     

排队论在地铁自动售检票系统中的应用

自动售检票(AFC)终端设备配置的合理性是车站高效、安全运营的关键,目前AFC终端设备的计算依据相关规范,以分期满足近、远期高峰小时预测客流量,未考虑乘客到达的规律和设施服务的随机性.考虑到客流到达的特性,引入排队论的概念,建立排队模型,通过计算可直接得出不同情况下的排队时间、服务时间等指标,直观的反应了设备配置对应的...     

常规潜艇燃料电池AIP的方案设计

介绍了燃料电池AIP的发展概况、特点,分析了我国常规潜艇采用燃料电池AIP的可能性及必要性。在此基础上,对燃料电池常规潜艇AIP进行方案设计,利用海军部系数法计算并选取模块功率,确定了燃料电池耗氧率以及根据续航力计算需要的储氧量,分析了3种不同规格的燃料电池功率模块对水下性能如续航力、续航时间和巡航航速的影响。方案设计结果表明,燃料电池AIP系统在我国常规潜艇中具有可行性,且在水下续航力、巡航时间等性能上比一般常规潜艇优越。