缓解期慢性阻塞性肺病患者最大呼吸压力测定及其临床意义

为探讨缓解期COPD患者呼吸肌功能，用Black法测定了167例缓解期COPD患者及277例同年龄组健康查体者最大呼吸压力（MEP和MIP）。结果：国人50～70岁健康者MEP男性（9．80±2．40）kPa，女性（7.11±2.33）kPa；MIP男性（6．16±2.32）kPa，女性（4．40±1．93）kPa。COPD患者仅男性MIP显著低于对照组（P＜0.01），余与对照组无显著差异（P＞0.05）。MIP降低主要受肺容量影响，而MEP无此现象。说明效解期COPD患者无呼吸肌疲劳。     

Graves病LATS刺激因子的免疫组织化学研究

用长效甲状腺刺激因子抗血清PAP法,对70例弥漫性毒性甲状腺肿的甲状腺组织,进行了免疫组织化学研究。结果发现70例中长效甲状腺刺激因子阳性者56例(80%),阴性者14例(20%)。甲状腺上皮细胞膜上长效甲状腺刺激因子的阳性反应,支持长效甲状腺刺激因子与TSH受体相结合。淋巴细胞亦有阳性反应,与淋巴细胞产生长效甲状腺刺激因子有关。认为长效甲状腺刺激因子与甲亢的病因有关,它是一种自身免疫性疾病。     

新建兰新铁路新疆段沿线盐渍土盐胀特性、机理与防治对策

以新建兰新铁路第二双线(新疆段)盐渍土为研究对象,通过室外、室内综合勘测试验,研究哈密地区盐渍土盐胀特性。试验结果表明:从总体规律来看,盐渍土盐胀过程主要集中在-5～10℃,;含水量-盐胀率曲线呈抛物线,盐胀率最大时含水量为15%左右。通过不同压实度状态下盐胀量试验得出:随压实度增大,盐胀量增大,但压实度低于90%时,盐胀量随压实度升高不明显。分析盐渍土盐胀机理:硫酸盐渍土盐胀作用主要由Na2SO4等易溶盐结晶前后体积变化引起。提出盐渍土防治结构模式:采用控制填料含盐量和压实度、路基填高、排水、坡面加固防护、路基包坡、铲除基础底层盐渍土层、换填粗颗粒渗水土、路基本体采用A组填料等综合性防护措施。     

病害隧道结构安全性评价模型与方法

基于结构-荷载法隧道计算理论,分别建立了隧道衬砌结构厚度不足、材料劣化及背后空洞3种病害结构计算模型,并进行了工程实例分析,阐述了病害隧道结构安全性评价的具体方法.研究结果表明:隧道结构病害的存在,改变了其整体刚度和受力状态,降低了整体承载能力.所建立的病害结构安全性评价模型能够综合考虑隧道常见病害对结构的影响,弥补了...     

高速铁路无砟轨道填方路堤病害加固设计与效果分析

以某无砟轨道客运专线铁路高填方路基沉降异常病害整治为工程背景,采用多综合手段探明了填方路基沉降异常病害的形成机理,通过现场试验对不破板条件下无砟轨道客运专线铁路高填方沉降异常加固设计方法进行方案比选,结合现场多种测试方法对注浆加固无砟轨道客运专线铁路高填方路基沉降异常病害的效果进行了检测分析。研究表明:填料质量和路基渗水软化是造成无砟轨道客专路基沉降异常的主要原因;在客运专线无砟轨道已铺设完成的情况下,经工艺试验和研究,采取袖阀管结合小导管注浆的加固高填方路基;不仅可以保证加固过程中轨道板的变形量,也可以使加固后路基的路基满足后续运营及相应的设计和规范要求;研究成果对同类型无砟轨道铺设后填方路基沉降异常处置有借鉴与参考价值。     

北疆新建铁路沿线重要病媒生物调查及其防控对策

目的了解北疆新建铁路沿线重要病媒生物的群落结构、地理分布和侵害情况。方法鼠类调查采用夹夜法;蚊类调查采用灯诱法、吸蚊器;蝇类调查采用笼诱法;蜚蠊调查采用粘捕法。结果北疆新建铁路沿线主要病媒生物类群有鼠类6科16属20种,具有重要流行病学意义的种类有灰旱獭、长尾黄鼠、大沙鼠以及褐家鼠等;蚊类发现3属5种,主要有米赛按蚊、里海伊蚊、凶小库蚊、尖音库蚊、刺扰伊蚊;蝇类发现4科13种,主要有家蝇、丝光绿蝇、厩腐蝇、麻蝇、夏厕蝇等;蜚蠊类均为德国小蠊。结论应加强对北疆新建铁路沿线病媒生物及其相关传染病的预防控制工作,为确保新建铁路的安全运营及沿线职工的健康安全,起到积极的促进作用。     

THE STUDIES OF SERUM IL-6,INF-αAMONG CHRONIC KESHAN DISEASE PATIENTS

Inrecentyears ,researchershavepaidmoreat tentiononthedamagemechanismofKeshandis ease ,especiallyininflammatoryreactionandimmu nologydisorder .Cytokine ,whichisakindofsmallmoleculeproteinorpolypeptide ,secretedmainlybyactivatedimmunocyte ,andwhichhasaspecialbio logicalfunction ,amongwhich ,IL 6 ,TNF αbe longtotheforeinflammatorycytokine ,whichplayanimportantroleintheoccurrenceandmaintenanceofimmunityandinflammation .InordertosearchthefunctionofcytokineinKeshandisease ,wehavetestedserumIL 6 …     

THE PROTECTIVE EFFECTS OF THE TOTAL SAPONIN OF DIPSACUS ASPEROIDES ON THE APOPTOSIS OF HIPPOCAMPAL NEURONS INDUCED BY β-AMYLOID PROTEIN

Objective To investigate the effects of the total saponin of Dipsacus asperoides (tSDA) and ginsenoside Rb1 (GRb1) on the apoptosis of primary cultured hippocampal neurons induced by β-amyloid protein (Aβ). Methods Primary cultured hippocampal neurons, the cultures were pretreated with tSDA and GRb1 on 10d for 24 hours respectively. Then the cultures were treated with 35μmol·L-1 Aβ25-35 for 24 hours, observed the changing of survival rate of neurons and the apoptosis of neurons with biochemical analysis combining immunofluorescent cytochemical double-staining technique. Results Hippocampal neurons were treated with 35μmol*L-1 Aβ for 24 hours, and survival rate of neurons downed to 52.6%. When neurons were pretreated by tSDA and GRb1, survival rate of neurons increased 11% to 15%. The findings of immunofluorescent cytochemical double-staining indicated that apoptotic neurons were obviously more than that of the blank group, reaching 43.9%.When neurons were pretreated by tSDA and GRb1, apoptotic neurons were downed to 16.6%, 10.8% respectively. Conclusion tSDA had the same effects as GRb1, protecting the neurons, antagonizing neurotoxicity of Aβ, increasing survival rate of neurons, and reducing apoptotic neurons induced by Aβ.     

气象因素对风湿性心脏病合并心力衰竭的影响

本文将我院过去25年风心病住院病人资料和本地区气象变化加以联系,结果发现,风心病因心力衰竭收住的人数与气压、气温和降水量几个气象要素密切有关,随气象要素在若干年内的大体变化,病人人数在25年内形成了相对应的4个高峰,高峰期伴发风湿活动率增加,患者平均年龄下降,各期因几个气象要素在时间和强度方面的组合不同而特点不同。     

STUDY ON THE THERAPEUTIC EFFECTS OF GINSENOSIDE Rg-1 AND GASTRODINE ON AD MODEL RATS INDUCED BY β-AMYLOID PEPTIDE (25-35)

Objective To study the therapeutic effects of Ginsenoside Rg-1 and Gastrodine on rats model of Alzheimer's disease(AD). Methods Aggregated β-Amyloid peptide (25-35) was injected into the lateral ventricle of rats to establish AD models. Ginsenoside Rg-1, Gastrodine and Ginsenoside Rg-1+Gastrodine were intraperitoneally injected into rats of each test group(Ginsenoside Rg-1∶10mg/kg·day; Gastrodine 100mg/kg·day) for 4 weeks, the rats of control group received equal volume of saline. Passive avoidance task and Morris maze test were done to assess the ability of learning and memory. The content of superoxide dismutase (SOD), malondiadehyde (MDA), total-antioxidative capability (T-AOC), Choline acetyltransferase (ChAT) and acetylcholinesterase (AchE) in brain tissue were measured. Results Ginsenoside Rg-1 and Gastrodine significantly improved learning and memory deficits in the rats with AD induced by β-Amyloid peptide (25-35) (P<0.05). Ginsenoside Rg-1+Gastrodine group were better than Ginsenoside Rg-1 group and Gastrodine group (P<0.05). Ginsenoside Rg-1 reduced the increase of SOD, MDA, but inhibited the decrease of T-AOC, AchE and ChAT; Gastrodine reduced the increase of SOD, MDA, while inhibited the decrease of T-AOC. Gastrodine could also prevent the activity of ChAT and AchE decline in AD rats. Conclusion Both Ginsenoside Rg-1 and Gastrodine have therapeutic effects on rats with AD; Ginsenoside Rg-1 and Gastrodine injection at the same time were better than only using one of them. Their mechanisms might different. Ginsenoside Rg-1 can not only inhibit peroxidation but also increase the activity of AchE and ChAT in brain tissue, while Gastrodine can inhibit peroxidation only, but it can't prevent the decline of ChAT and AchE activity in AD rats.