县级国、省道公路沥青路面维修施工工艺

根据公路沥青路面病害的性质进行了分类,并对不同的病害分类有针对性的提出了处理方法,为保证处理方法的有效性和实用性进一步提出了质量控制措施。     

湾坞特大桥变宽箱梁悬灌施工关键技术

结合温福铁路湾坞特大桥第三联箱梁的施工实践,针对变宽箱梁的构造特点,阐述了变宽箱梁悬灌施工过程中将原使用的挂篮走行装置及锚固系统进行改进、对箱梁两侧不平衡重采取压重等技术措施,解决了变宽箱梁悬灌施工时挂篮行走和该桥线形控制的难题。     

火山岩熔空洞地区高等级公路建设现状与展望

针对火山岩熔空洞地区公路建设相关研究成果,总结了火山岩熔空洞地区的形成过程及其物理、力学性质和工程特点,分析了火山岩熔空洞地区易产生的路基病害.在此基础之上,对该地区的公路建设进行了展望.     

多年冻土路基病害及防治措施探讨

某公路所处区域属高原,人烟稀少、空气稀薄,为季节性冻土及高海拔多年冻土地区,其工程性质随温度、应力和水分变化而变化,针对该种情况,结合本项目特点,重点对冻土路基病害类型及防治措施进行阐述,可为相关施工提供参考。     

海洋环境下的公路隧道口病害防治方法研究

针对浙东海岛公路隧道洞口病害的频发问题,在分析环境影响、发病类型、致病机理的基础上,提出病害“预控”防治理念和方法,通过建立隧道口遭灾模式,确定“最不利条件”下的洞口工程设计参数,对病害实行精准“预控”,并采用系列工程质量控制措施,系统阻断有害因素的生成与累积,最终实现隧道口病害的高效、全程防治。     

The β-amyloid protein induces S100β expression in rat hippocampus through a mechanism that involves IL-1

Objective To explore the effect of β-amyloid protein (Aβ) on S100β expression in rat hippocampus and its mechanisms. Methods At 7 days after bilateral stereotaxis injection of different dose of fibrillar Aβ 25-35 and interluekin-1 receptor antagonist (IL-1ra) into the rat CA1 region, the learning and memory abilities of rats were tested with passive avoidance task. Amyloid deposition was detected by using Congo red staining technique. Nissl staining and immunohistochemical techniques were used to analyze the number of neurons, and GFAP and the S100β expression in hippocampal CA1 region , respectively. Results After fibrillar Aβ injection, the step-through latency of rats was significantly shortened compared to that of the control group. The GFAP positive astrocytes were found surrounding amyloid deposition. Neuronal loss occurred in the pyramidal cell layer of CA1 region. The number of S100β positive cells in Aβ-treated group was significantly increased compared with that in the control group. After IL-1ra injection, the number of S100β positive cells was significantly decreased. Conclusion Intrahippocampal injection of Aβ 25-35 could cause similar pathologic changes of Alzheimer's disease. Aβ 25-35 was capable of up-regulating S100β expression in a dose-dependent manner. The injection of IL-1ra could attenuate the effect of Aβ on S100β expression.     

OCCURRENCE CHARACTERISTIC OF KASHIN-BECK DISEASE BASED ON NUCLEAR FAMILY PEDIGREES

Kashin Beckdisease (KBD )isanendemicos teochondropathyresultingfromimpairedendochon drialdevelopmentinchildren .Itmanifestswithsecondarychronicdeformitiesandosteoarthrosisinadults.Geographically ,thediseaseoccursmainlyinadiagonalbeltrangingfromthenortheasttothesouthwestofChina (KBDarea) .Thisareaischar acterizedbyalowfoodseleniumcontent .Thereare2 .5millionpatientswithKBDand 30millionpeo pleareatrisk[1] .TheclinicalmanifestationsofKBDareflexionoftheterminalpartofthefingersorcrookedfinger…     

女性阿尔茨海默病与雌激素水平的关系

目的分析女性阿尔茨海默病(AD)患者血清雌激素水平改变以及雌激素水平、初潮年龄、绝经年龄与AD严重程度的关系。方法采用1∶1病例配对的研究方法,通过问卷调查对全部研究对象进行MMSE、ADL、POD、FOM、WISE、HMT抑郁量表等测验;调查研究对象的初潮年龄、绝经年龄、怀孕次数等;用放射免疫法测定血清性激素水平。结果AD组雌二醇(E2)水平明显低于对照组,有显著性差异(P<0.05);AD组血清E2水平与痴呆严重程度和MMSE分值呈正相关(P<0.05);AD组初潮年龄明显大于对照组,绝经年龄明显早于对照组,有显著性差异(P<0.05);怀孕次数两组间比较无统计学差异(P>0.05),但AD组仍少于对照组。结论女性AD患者雌激素水平降低,雌激素缺乏可能是女性AD的危险因素之一。     

蛤蟆岭隧道病害处治

蛤蟆岭隧道为二级公路中隧道，使用过程中出现了衬砌裂缝、渗漏水等病害状况，简要分析了病害成因，并根据病害程度，按分类治理原则，因地制宜，采取了相应的处治方法与措施。     

隧道进口段病害处治研究

隧道的进口段和出口段一般处于围岩较弱和容易出现病害的地方,因此对其进行必要的处治是隧道施工的重点环节。