独墩单铰支座曲线梁桥通病分析及治理

针对目前独墩单铰支座曲线梁桥出现的通病 ,就温度对其梁体的变位影响以及预应力等因素对其支座支反力的作用进行了实例剖析。在此基础上探讨此类桥梁的支承体系的病害整治对策 ,并通过加固实例的监测结果予以验证     

波纹钢板套衬解决隧道衬砌掉落病害的效果分析

为解决衬砌起层剥落病害问题,提出使用波纹钢板套衬的衬砌加固方法,即使用化学锚栓将波纹钢板与衬砌混凝土连接,并在中间添加填充材料。考虑衬砌混凝土掉落时波纹钢板单独作用,波纹钢板与化学锚栓共同作用,波纹钢板、化学锚栓和填充层共同作用3种不同工况,针对3种工况建立相应的有限元数值分析模型,并对加固效果进行计算和分析。计算结果表明： 波纹钢板单独作用时结构处于最不利情况,此时波纹钢板顶部挠度为110.2 mm,应力为136.8 MPa,满足变形和受力要求; 当考虑化学锚栓和填充层的作用时,结构响应最小。     

急流槽病害的成因及预防措施

介绍了急流槽病害的分类和成因,提出了急流槽病害的预防措施。     

AQP4在COPD支气管黏膜的表达及其与患者肺功能、气道黏膜炎症的相关性

目的通过免疫组化法检测支气管黏膜中水通道蛋白-4(aquaporin-4,AQP4)的表达,观察正常组和慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)组支气管黏膜中AQP4表达与气道黏膜炎症及肺功能的关系,明确AQP4在COPD发生、发展中的作用,为COPD的防治开辟新途径。方法选择正常人和COPD患者各30例,测试肺功能,并行支气管镜检查,取得支气管黏膜标本,用免疫组化法检测AQP4表达,HE染色观察支气管黏膜炎症细胞浸润程度。结果COPD组较对照组AQP4表达减弱有极显著差异(P<0.001)。AQP4表达和FEV1/FVC、FEV1/pred%呈正相关(P<0.001),与支气管黏膜炎症严重程度呈负相关(P<0.001)。结论COPD患者AQP4表达减少可能是其肺功能下降及气道炎症加重的原因之一。临床上可以通过改善AQP4治疗COPD。     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

Study on T lymphocyte subsets and NK cells in patients with Graves＇ disease combined with type 2 diabetes

Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM.     

高等级公路膨胀土路基病害与处治措施

膨胀土是一种对工程建设有特殊危害的土。针对膨胀土公路路基的破坏形式,分析膨胀土路基破坏的原因,并结合某高速公路膨胀土路基病害探讨膨胀土路基的处治措施,可为此类路基处治提供参考。     

旧水泥混凝土路面的维修改造

探讨水泥混凝土路面维修改造措施和关键技术,分析旧水泥混凝土路面产生反射裂缝的机理,在此基础上,提出旧水泥混凝土路面加铺处治措施和方法。     

105国道新丰段加铺水泥砼路面改造探讨

以105国道新丰段路面大修工程为依据,通过对旧路面的调查,分析了水泥砼路面损坏的原因,并采用了对应的处治措施。     

裸洞隧道病害形成耦合机理分析

裸洞隧道病害的产生主要是地下应力场在损伤、渗流、温度等因素的耦合作用下形成的,是非常复杂的非线性耦合过程。从裸洞隧道开挖后的弹塑性应力场出发,使用Bui损伤模型与地下水渗流场组成的激励-反应耦合系统加以研究病害形成的耦合机理。结果表明,裸洞隧道病害明显产生是损伤和渗流耦合强度因子在0.5左右产生的,随着隧道围岩裂隙的扩展和损伤程度的加剧,围岩塑性区半径随水压力的增加而迅速增大,加速隧道病害的产生,这为探明裸洞隧道病害形成机理研究、治理与防护起到一定的理论指导意义。