The study of correlative factors to resistin and its regression equation in type 2 diabetes

Objective To study the changes of resistin and the relationship between resistin and other indexes in patients with type 2 diabetes mellitus. Methods Seventy patients with type 2 diabetics were chosen and divided into three groups according to weight index and 15 healthy persons were chosen as controls. ELISA was adopted to determine resistin concentration. Oxydase method was adopted to measure blood sugar. Radio immunoassay was used to measure insulin level. Results Resistin concentration of patient groups r(23.06±9.34)μg/L ] was significantly higher than that of control group [( 9. 89±4. 47) μg/L, P<0. 01 ]. Resistin was positively related to body mass index (r = 0.4 467) and fat distribution (r= 0. 3 314, P<0.01). Resistin was also positively correlated to the area under the curve of sugar tolerance (r=0. 7 063, P<0. 01), negatively related to the insulin resistance index (r=-0. 4 154, P<0.01), but not related to area under the curve of synchronous insulin release (P>0. 05). And a formula was obtainted : Resistin=- 15. 869 0. 339×GAUC 0.790×BMI. Conclusion The level of reslstin in type 2 diabetics is higher. And reslstin is related to other factors. This formula is of great significance for clinical study of diabetic's disor- ders.     

COX-2蛋白表达与口腔鳞癌侵袭转移的关系

从COX-2的生物学特性，可知促进口腔鳞癌侵袭转移的机制为促进肿瘤新生血管的生成、刺激肿瘤细胞的增殖、抑制肿瘤细胞的凋亡、促进肿瘤的浸润和转移、抑制机体的免疫反应、参与前致癌物的活化。（可应用COX-2抑制剂防治肿瘤）     

ATS在CA6121URN2城市客车冷却系的设计

ATS具有结构简单、布置方便、节省能源、保护环境、可提高发动机工作寿命等诸多优点。近年来,在客车发动机冷却系统中得到越来越多的应用。目前ATS的不足之处在于价格昂贵,在大功率发动机的配套上使用受限。本文是ATS在CA6121URN2城市客车冷却系设计中的应用实例。     

汽车传动轴CO_2气体保护焊接工艺研究

在对B480QZR和40Cr两种不同钢材的焊接性能分析的基础上,研究和制定了B480QZR+40Cr异种钢焊接接头的工艺方案,通过采用CO2气体保护焊的焊接实践,或得了较好的焊接接头质量,满足了传动轴产品的设计和使用要求。     

二维矩形块布局的交叉熵方法实现

给定一个小矩形块集和一个固定宽度而高度变化的大矩形的二维布局问题,就是将这矩形集中的所有矩形正交布置于这个大矩形中,并且保证矩形块之间不发生重叠,目的就是使得布局后这个大矩形块的高度最小.本文提出通过DROP或DROPF（DROP FILL）的启发式解码策略与交叉熵算法相结合求解该类问题.试验结果显示,算法稳定有效,较经典元启发式算法在提高空间利用率上有较大提高.     

V(D)J重组起始阶段的研究进展与展望

重组激活基因(recombination activating gene)1和2编码的RAG1和RAG2蛋白通过对V(D)J重组起始阶段的调节作用,使得抗原受体基因重排严格地按组织、细胞发育阶段进行。本文将就RAG蛋白结合和催化断裂抗原受体基因机制作简要介绍。这些新发现明确了体内V(D)J重组发生的部位以及其出现错误时可能发生的地方,提示V(D)J重组机制不仅对淋巴细胞正常发育起关键性作用,而且对基因组不稳定性和淋巴系统恶性肿瘤的发生也具有重要意义。     

肾母细胞瘤中ERCC1、TUBB3、TOP2A mRNA的表达及临床意义

目的探讨核苷酸切除修复交叉互补基因(excision repair cross complementation 1,ERCC1)、3型β微管蛋白编码基因(ClassⅢβ-tubulin,TUBB3)和DNA拓扑异构酶Ⅱα(TopoisomeraseⅡA,TOP2A)mRNA在小儿肾母细胞瘤组织中的表达及临床意义。方法收集18例肾母细胞瘤组织标本及14例癌旁组织标本,通过分支-DNA液相芯片法检测标本中ERCC1、TUBB3、TOP2A mRNA的表达水平,并分析上述基因表达与肾母细胞瘤临床病理的关系。结果肾母细胞瘤组织中ERCC1、TUBB3和TOP2A高表达率分别为44.4%、50.0%和66.7%,均显著高于癌旁组织的7.1%、7.1%和14.3%,差异有统计学意义(P<0.05)。ERCC1高表达率与肾母细胞瘤临床分期和病理类型有关(P<0.05),TOP2A高表达率与肾母细胞瘤临床分期相关(P<0.05)。结论小儿肾母细胞瘤组织中ERCC1、TUBB3和TOP2A mRNA表达高于癌旁组织,可能参与肾母细胞瘤的发生发展过程。     

Implications of globalization for co 2 emissions from transport

Transport accounts for about 25% of global CO 2 emissions. Transport activities are on the rise in the coming decades. Would associated CO 2 emissions move upwards as well, and at what rate? The present paper explores the future of these CO 2 emissions, starting from four scenarios for global transport. Considering fuel consumption, energy efficiencies in transport, occupancy rates of transport means, size of cars on the market, and possible environmental policies we find CO 2 emissions are persistently increasing, especially in the less wealthy areas of the world. In Europe, policies that attempt to control mobility and also limit CO 2 emissions may succeed in reducing emissions growth by about 30%. Efforts to increase energy efficiency of transport, in particular road transport, would contribute most to such reduction.     

新型皮带修补技术——蒂普拓普T2胶枪修补系统的应用

使用热硫化热补方式,修理皮带撕裂工作量大,维修时间长,严重影响企业生产.新的皮带机修补技术T2胶枪应运而生.阐述了该T2胶枪的技术原理、T2胶枪的结构、特点和使用工序.通过应用实例,证明该技术取得良好的经济效益,为用户提供了一种创新的维修理念.     

Variations in ectoenzymatic hydrolytic activity in an oligotrophic environment (Southern Tyrrhenian Sea, W Mediterranean)

The variations in the expression of two hydrolytic ectoenzymes (leucine aminopeptidase – LA – and β glucosidase — BG) were studied in the southern Tyrrhenian Sea during spring 2004. This area is characterised by a complex morphology and hydrodynamism, which generate significant differences between different sectors, particularly in the 0–100 m layer. However, the area generally exhibits oligotrophic features such as low autotrophic pigment and organic matter concentrations and a higher bacterial biomass than the phytoplanktonic one. Despite this general bottom-up pressure, adaptations by the microbial consumers were indicated by the ectoenzymatic activities and by the relationships between the enzymes, their organic substrates and their producers (namely the bacteria). In particular, bacteria were able to exploit the inorganic N supply (nitrite + nitrate provided by irregular intrusions of intermediate waters) to escape the bottom-up limitation and produce enzymes such as BG devoted to the degradation of cellulose remnants and, therefore, also able to take advantage on this refractory organic matter. In the 200–800 m layer, where trophic limitation was strong due to the low values of potentially-labile organic matter (namely proteins), the peculiar hydrodynamism led to the formation of nepheloid layers rich in organic matter, which provided the bacteria with substrates and allowed the development of a significant correlation between LA activity and its own organic substrate. Furthermore, a reduction of the bottom-up pressure was also indicated by a higher mean bacteria cell size in the entire water column of the central and eastern sectors, and a significantly increased expression of BG related to the increase in the cell size.The ectoenzymatic activities, therefore, suggested that the southern Tyrrhenian Sea should be considered as a mosaic of subsystems, where the peculiar hydrological features stimulate bacterial adaptations and enhance the channelling of energy embedded in refractory materials into the food web.