羟基喜树碱对人胆管癌QBC939裸鼠移植瘤PS2、COX-2的影响

目的探讨羟基喜树碱对人胆管癌QBC939裸鼠移植瘤的乳癌相关肽(PS2)、环氧合酶-2(COX-2)的影响,分析PS2、COX-2与肿瘤发生、发展的关系。方法建立人胆管癌QBC939细胞株裸鼠皮下移植瘤模型,将30只裸鼠随机分成对照组、羟基喜树碱低剂量组和羟基喜树碱高剂量组,观察移植瘤体生长情况,RT-PCR法检测瘤体内PS2、COX-2 mRNA表达。结果与对照组比,羟基喜树碱低、高剂量组都可使移植瘤体的PS2 mRNA表达增高;COX-2 mRNA表达降低,且瘤体生长减慢,与对照组比较差异有统计学意义(P<0.01)。结论羟基喜树碱可降低移植瘤COX-2 mRNA表达,增高移植瘤体的PS2 mRNA表达,并使人胆管癌裸鼠移植瘤生长减慢。     

健胃愈疡颗粒对慢性胃炎伴幽门螺杆菌感染胃黏膜PAF、PS2的表达及对上皮细胞凋亡的影响

目的观察健胃愈疡颗粒(JWYY)对幽门螺杆菌相关性胃炎胃黏膜乳癌相关肽(PS2)和血小板活化因子(plate-let activating factor,PAF)表达的变化,并分析其可能的作用机制。方法80例幽门螺杆菌感染慢性胃炎患者随机分为2组,治疗组42例给予健胃愈疡颗粒治疗,对照组38例给予西药三联药物治疗。应用胃镜下活检胃黏膜组织快速尿素酶和Warthin-Starry染色法检测幽门螺杆菌,应用Western blot检测PS2、PAF表达变化。应用末端转移酶介导的dUTP切口末段标记法(TUNEL)检测细胞凋亡。第4周复查胃镜。结果治疗组凋亡指数明显比对照组减少(P<0.05),治疗组总有效率高于对照组(P<0.05)。Western blot检测显示:JWYY颗粒可上调PS2并下调PAF的表达,而对照组对胃黏膜PS2和PAF的表达影响不大。结论健胃愈疡颗粒治疗幽门螺杆菌(Hp)相关性胃炎可能与杀灭Hp、上调PS2和下调PAF的表达来抑制细胞凋亡有关。     

汽车全液晶车速里程表研制

介绍了以MC68HC9S12DP256为控制芯片,基于PCF8533液晶驱动芯片的全数字式液晶车速里程表,实现了系统的低功耗和直观良好的显示界面。     

广州西二环岩溶地段桩基施工技术方法探讨

岩溶区的桩基施工是工程建设中的一个难题。通过广州西二环高速公路沿线桩基施工过程中所碰到的岩溶地区桩基问题,提出相应的处理方法,并对处理结果进行分析,可为今后的工程建设提供参考。     

探索能源危机下汽车产业的发展

柴油机、混合动力、燃料电池代表了汽车动力推进系统近期、中期和远期的解决方案。短期内混合动力和燃料电池由于技术复杂等原因,导致价格过于昂贵,因此现阶段最具商业推广价值的应该是柴油化：而混合动力是向燃料电池过渡的中期方案;燃料电池则可以理解为终极方案。     

The effectiveness of a European speed limit versus an international bunker-levy to reduce CO2 emissions from container shipping

In the fight to reduce CO₂ emissions from international shipping, a bunker-levy is currently under consideration at the International Maritime Organization (IMO). Faced with the inability of the IMO to reach an agreement in the short term, the European Commission is now contemplating a unilateral measure of a speed limit for all ships entering European Union (EU) ports. This paper argues that this measure is counterproductive for two reasons. Firstly, because it may ultimately generate more emissions and incur a cost per ton of CO₂ which is more than society is willing to pay. Secondly, because it is sub-optimal compared to results obtained if an international bunker-levy was to be implemented. These elements are illustrated using two direct transatlantic services operated in 2010.     

电动汽车V2G关键技术研究综述

V2G(Vehicle-to-grid)技术能够优化能源效率,参与电网调度,促进电网的安全性、稳定性、可靠性和经济性。文章首先阐述了V2G的概念,其次从电动汽车储能应用研究、电动汽车可调度容量研究和电动汽车移动储能对于配网影响及其协同控制研究等三个方面,综述了国内外V2G技术的研究状况。最后介绍了国内外部分有关V2G的示范应用,并对V2G关键技术的国内外研究状况进行了总结。     

盲源分离技术在水声信号中的应用研究

通过研究α稳定分布,提出海洋噪声、舰船辐射噪声等符合低阶α稳定分布,在进行对称α稳定分布且独立的随机源信号进行盲分离处理时,若仍然采用高斯分布将不收敛。本文设计了分数低阶矩阵盲源分离算法,最后通过实验对比本文所设计算法和时延分离算法。实验结果表明:本文所设计的算法对于α稳定分布且有独立的随机信号,具有较好的收敛性,能够有效实现盲源信号分离。通过从复杂的海洋噪声中仍能较好地提取出船舱辐射噪声的实验,说明即使信噪比发生变化,源信号分离后相似系数较分离前仍然有稳定地提高。     

Environmental and transport effects of warehouse relocationing: evidence from Norway

Reducing traffic volumes and CO2-emissions from freight transport has proven difficult in many countries. Although the increasing suburbanization of warehouses is seen as a relevant land use trend, comprehensive analyses of their impact remain scarce. This study uses real data in modeling transport, costs, environmental and modal effects from warehouse relocations around Oslo and Trondheim (Norway). Results indicate that for Oslo, traffic performance (ton-km), CO2-emissions, and transport costs increase following warehouse suburbanization. For Trondheim, transport performance and CO2-emissions increase less, while transport costs decrease marginally. We conclude that specific case characteristics (geography and trade patterns) are important in determining the strength and direction of effects, and expect that common concomitant developments (warehouse centralization and consolidation) would lead to more pronounced results. Our findings confirm some, but challenge other, findings from the relatively scarcely literature available. Finally, the study's more general insights and observations can help advance similar analyses beyond Norway.     

机械复合管在海底管道中的应用

原油、湿气含有CO2或H2S是造成海底管道内腐蚀失效的主要原因之一。机械复合管作为一种新型管材,可以有效解决CO2或H2S造成的内腐蚀问题,在国际上得到了广泛应用,但其在国内油气田开发海底管道中,尚无应用先例。文中介绍了机械复合管的制造原理、设计制造规范、用作海底管道的技术要求、海上安装技术特点以及应用前景。文中研究了机械复合管在海底管道中应用对设计制造和安装技术的要求,以推动其在国内油气田开发海底管道中的应用。