中药治疗后MMP-9、TIMP-1及CA125在异位和在位子宫内膜中的表达

目的 探讨中医药治疗子宫腺肌症的作用机制.方法 37例行全子宫切除术的子宫腺肌症患者术前分为中药治疗组(n=17)和对照组(n=20).子宫内膜作为在位内膜标本,腺肌瘤作为异位内膜标本.采用免疫组化法测定并比较在位和异位内膜中基质金属蛋白酶-9(MMP-9)和组织金属蛋白酶抑制剂-1(TIMP-1)的表达水平,并观察两组患者治疗前、后血清CA125的变化.结果 中药治疗组异位内膜组织中,MMP-9在腺上皮细胞内的表达显著低于对照组(P<0.05),TIMP-1的表达显著高于对照组(P<0.05),MMP-9/TIMP-1比值显著低于对照组(P<0.05).中药组治疗后血清CA125 明显降低,与治疗前及对照组比较差异均有统计学意义(P<0.05).结论 中药可能通过下调MMP-9/TIMP-1的比值及降低血清CA125水平来控制异位内膜组织的种植侵袭.     

Construction of expression vector for NT4-ADNF-9 fusion gene

Objective To construct the prokaryotic expression vector bearing fusion gene NT4-ADNF-9 and lay foundation for further study on genetic therapy of neuraseusory deafness. Methods By means of asymmetrical prince/ template, double stranded eDNA of activity dependent neurotrophic factor-9 (ADNF-9) was obtained, which included restriction enzymes sites on the two extremities. ADNF-9 eDNA was ligated to the signal and leader peptides of nenrotrophin 4 (NT4), and the fusion gene was named NT4-ADNF-9. Then it was suheluned into prokaryotic expression vector pBV220, and called pBV220/ NT4-ADNF-9. Results Evidences of DNA sequence analysis and restrtction enzymes digestion showed that we recombined ADNF-9 eDNA to the 3'terminal of the signal and leader peptides of NT4, and the fusion gene was subcluned into pBV220 successfully. Bioactivity of the products was proved that it could support the cell survival and neurite growth in the primary cultures of dorsal root ganglia (DRG) of embryonic day-8 cbicken neurons as compared to the control. Conclusion Prokaryotic expression vector pBV220/NT4-ADNF-9 can be constructed successfully and the bioactivtty is satisfactory.     

基于汽车ECU串口的代码下载与调试方法的实现

提出一种基于串口通信来实现对汽车电控单元ECU代码的下载和调试方法,以解决长期以来依赖BDM对ECU进行代码下载和调试过程中出现的诸多不便.以美国飞思卡尔汽车级微控制芯片HCS 9S12为研究对象,通过自主开发的调试软件实现了无BDM对ECU的代码下载与调试,实践证明该方法简单、可靠、成本低,有一定的应用推广价值.     

Na3La9B8O27:Ln3+(Ln=Eu或Tb)荧光体的制备与发光性能

采用高温固相合成技术、溶胶-凝胶法、助熔剂法制备了Na3La9B8O27：Ln^3＋（Ln=Eu或Tb）荧光体,确定了固相反应制备该荧光体适宜的组分re．g,j．分别测试、解释了Na3La9B8O27：Ln^3＋和Na3La9B8O27：Tb^3激发光谱和发射光谱．比较了不同方法制备的荧光体的发光效率,并对产生的差异进行分析和讨论,助熔剂法得到的荧光体发光效率最高．     

基于二乘二取二冗余-安全控制的地铁LCU设计

简述LCU的发展3个阶段,针对城轨地铁车辆应用,介绍一种基于二乘二取二冗余-安全控制架构技术的下一代LCU的原理、组成和故障诊断方案,相较于双机热备冗余的LCU,能够获得更高的安全性和可靠性。     

一种储罐底板漏磁检测小车的控制系统硬件设计

针对储罐底板的表面情况和结构特征以及储罐的环境特征,设计了一种基于MC9S12XS128单片机的储罐底板自动化检测小车,以MC9S12XS128单片机为主控制器,采用激光距离传感器作为定位检测装置,主要介绍了检测小车机械结构和硬件电路结构,并对检测小车沿规划路径行走进行了实验,验证了该控制系统的可行性和正确性。理论分析和实验证明,储罐底板自动化检测小车能够携带励磁装置和检测探头在储罐底板上沿规划路径自动行走,提高了检测效率,降低了劳动强度,进一步推动了石油储运的安全运行。     

高速受流性能探讨

简述高速情况下影响机车受流性能的几个主要因素及其机理， 并对提高受流性能提出了简统化的设想。     

EXPLORE ON DIAGNOSTIC AND PROGNOSTIC VALUES OF EXTRAHEPATIC CHOLANGIOCARCINOMA： UTILITY OF SERUM CA19-9 AND SERUM CEA

Extrahepaticcholangiocarcinoma (EHCC)isamalignanttumorarisingfrombileductepithelium .Unlikemosthumancancers ,atissuediagnosisofcholangiocarcinomaisoftenextremelydifficultbe causeoftumorlocation ,size ,anddesmoplasticcharacteristics .Percutaneousfineneedleaspirationisfrequentlynotpossiblebecausemanyofthesetu morsarelocatedintheliverhilumamidlargevascu larstructure .Furthermore ,tumormassesareoftennotevenidentifiablebyCT ,ultrasound ,ormag neticresonanceimaging .Endoscopicapproachesarealsoofl…     

SS9型机车轴箱拉杆横向刚度及其橡胶件强度有限元分析

建立SS9型机车轴箱拉杆的有限元模型,并对其横向刚度进行计算,计算结果与测试结果吻合。同时对拉杆橡胶件强度进行分析,认为一系横向位移大是导致拉杆失效的主要原因,并提出改进措施。     

交流传动与交直传动电力机车的技术经济性对比

通过对SS9型机车和DJ型机车在外形、性能、维护及运行成本和收益等方面的对比分析，指出交直传动固有的缺点，说明交流传动是铁路牵引动力发展的方向。