新型自体肿瘤细胞疫苗治疗进展期肿瘤患者的免疫学检测

目的　探讨自体肿瘤疫苗的作用机制。方法　 2 0例进展期肿瘤患者术后第 4周开始以自体肿瘤细胞疫苗行主动免疫治疗。免疫接种共 4次 ,每次间隔 7～ 10d ;接种前 3d及第 4次接种后一周 ,采集外周血 ,分离单个核细胞 ,以流式细胞分析术 /细胞内细胞因子检测法测定CD8+ IFN γ+ ,CD8+ IL 10 + 细胞及CD4+ IFN γ+ ,CD4+ IL 10 + 细胞 ;同时采集血清 ,ELISA法检测血清IFN γ、IL 10水平。结果　自体肿瘤细胞疫苗治疗后 :①血清IFN γ水平升高 [(7.16± 2 .91)ng·L- 1升至 (11.68± 4.86)ng·L- 1,P <0 .0 5] ;而IL 10水平下降 [2 1.0 4± 13 .81)ng·L- 1降至 (13 .41± 5.71)ng·L- 1,P <0 .0 5] ;②CD8+ IFN γ+ 阳性细胞由 (3 .80± 1.45) %升至 (6.94± 2 .63 ) % ;CD4+ IFN γ+ 阳性细胞由 (3 .0 9± 1.52 ) %升至 (5.2 0± 2 .94) % (P <0 .0 5) ;③病人耐受良好。结论　自体瘤细胞疫苗免疫后可改善肿瘤患者细胞介导的抗瘤免疫反应     

神经网络在车辆半主动控制中的应用

针对车辆半主动悬挂模型的非线性特性，研究了采用神经网络的自适应控制在车辆悬挂半主动控制中的应用，设计了采用前馈神经网络的辩识器和控制器，对控制器网络采用的学习规则进行了分析。仿真计算表明，采用神经网络自适应控制方法能有效改善车辆的平稳性，采用的神经网络辩识器和控制器的改进BP算法是有效的。     

基于最佳逼近理论的主动吸收造波算法研究

在海洋工程水池试验中,二次反射波会严重影响实验的可靠性和准确性,如何消除反射波成为一个重要课题。针对MARINTEK水池为仿真对象展开相关研究,运用目前较为成熟的主动吸收造波算法理论,解算摇板式造波机的传递函数,在此基础上应用最佳逼近理论,设计出相应的数字滤波器,来达到同等的主动吸收造波效果,并验证该方法的有效性,从而实现模拟滤波器向数字滤波器的转换。仿真结果显示,数字滤波器输出与标准(主动吸收造波算法理论)输出有着良好的拟合效果,表明所设计的数字滤波器能够到达预期的主动吸收造波效果。本研究的意义在于,初步实现了主动吸收造波算法从理论到实际应用的转换,为工程上的应用提供良好的依据,有助于提高波浪试验的准确性。     

基于快速终端滑模自抗扰的船舶曲线航迹跟踪控制

针对欠驱动船舶的曲线航迹跟踪问题,首先采用自抗扰控制技术,通过扩张状态观测器实时估计和补偿系统的内部和外界扰动,将非线性快速终端滑模引入误差反馈控制环节,并采用幂指数趋近律,设计出快速终端滑模-自抗扰控制律,提高系统的收敛速度和误差跟踪精度,减小系统的抖振;然后对野本船舶模型简化变形,构造降维方程,将航迹跟踪问题转化为航向镇定问题.Simulink仿真结果表明,控制器能够实现船舶对期望曲线航迹的快速、精确跟踪,具有良好控制效果.     

Vehicle rollover avoidance by application of gain-scheduled LQR controllers using state observers

Many researches have been conducted in the area of control applied to vehicle dynamics, aiming at reducing the possibility of the occurrence of the type of accident known as rollover. In this research, based on a common nonlinear model and its linearisation, a method for properly selecting matrices for solving the Riccati equation considering different speeds was proposed. The method showed in which ways speed really influences the choice of controller gains. By developing the dynamic equations for the yaw- and roll-coupled motions and modelling of controllers and state observers, it is possible to compare the efficacy of this control strategy using both linear and nonlinear simulations using Matlab. Significant results were obtained regarding the reduction of the rollover coefficient for a double-lane change manoeuvre at different speeds, thus indicating advantages of using this controller in practical cases.     

Robust control and actuator dynamics compensation for railway vehicles

A robust controller is designed for active steering of a high speed train bogie with solid axle wheel sets to reduce track irregularity effects on the vehicle’s dynamics and improve stability and curving performance. A half-car railway vehicle model with seven degrees of freedom equipped with practical accelerometers and angular velocity sensors is considered for the H_∞ control design. The controller is robust against the wheel/rail contact parameter variations. Field measurement data are used as the track irregularities in simulations. The control force is applied to the vehicle model via ball-screw electromechanical actuators. To compensate the actuator dynamics, the time delay is identified online and is used in a second-order polynomial extrapolation carried out to predict and modify the control command to the actuator. The performance of the proposed controller and actuator dynamics compensation technique are examined on a one-car railway vehicle model with realistic structural parameters and nonlinear wheel and rail profiles. The results showed that for the case of nonlinear wheel and rail profiles significant improvements in the active control performance can be achieved using the proposed compensation technique.     

汽车车内噪声有源控制技术

有源噪声控制技术是目前国内外噪声控制界的研究热点。对有源噪声控制的概念、原理和实现作了介绍。根据有源控制方法对于低频噪声控制的优势,结合车内噪声的特点和现代控制领域的理论发展,讨论了在车内应用有源噪声控制技术的可行性,提出了一条可行的技术路线。     

新型军用柴油发电机组控制器研究开发

针对军用环境下对柴油发电机组控制器的特殊要求,选用新型电子元器件提高产品的集成度和可靠性,硬件采用新型的电容式触摸按键和滑动条技术以及下一代显示技术(有机发光显示技术)OLED,并进行模块化设计,接口丰富,使系统扩展更加灵活。在软件开发方面引入嵌入式操作系统μCLinux。     

摆式动车组主动控制受电弓系统的研究

分析了摆式动车组车体倾摆时对受电弓的影响,研究了国外摆式列车的发展情况,提出了采用主动控制受电弓系统的方案,对控制系统进行了运动学、受力分析、几何关系、控制规律等方面的研究。     

FEMUR SHAPE RECOVERY FROM VOLUMETRIC IMAGES USING 3-D DEFORMABLE MODELS

IntroductionThe rupture of the anterior cruciate ligament( ACL) has become the most common knee in-juries.In operation of ACL reconstruction,thesurgeons have to find the optimal attachmentpoints resulting in a low anisometry of the graft,while preventing impingement between the graftand the femoral notch.Markus Fleute andStéphane lavallée[1] proposed a real- time systemfor computer- assisted ACL surgery.A recentadvance in surgery is minimally invasive tech-nique that can avoid the large…