Role of candesartan against cerebral ischemia and oxidative damage in normotensive rats

Objective Angiotensin Ⅱ (Ang Ⅱ ) contributes to modulating blood pressure by stimulation of Ang Ⅱ AT1 receptors. We devised a rat transient middle cerebral artery occlusion (MCAO) model to assess whether oxidative damage is decreased after pretreatment with Angiotensin Ⅱ AT1 receptor blocker (ARB). Methods After 2 weeks pretreatment with ARB 0. 5 and 1 mg/kg, the male Wister rats were subjected to 2 h middle cerebral artery occlusion (MCAO). At 24 h, the lumen diameter of middle cerebral artery, the plasma level of 8-hydroxy-2'-deoxyguanosine (8-OHdG), and HIF-1 a levels were recorded and compared. Results After pretrcatment with ARB 0.5 and 1 mg/kg, blood pressure did not significantly change compared with that of controls. In the group of candesartan at 1 mg/(kg· day), the lumen diameter was significantly increased compared to that in control group [(86.0±5.0) μm vs. (69.0± 2.1) μm; P<0. 01, n = 6- 8]. The plasma 8-OHdG levels of ARB pretreatment groups were decreased. In immunohistochemical findings, 8-OHdG- and HIF-1α-containing cells in ARB pretreatment groups were decreased. Conclusion Brain ischemia and oxidative damage can be reversed by AT1 receptor blockade in normotensive rats after transient cerebral artery occlusion.     

船舶搁浅于台型礁石场景极限强度解析预报方法

针对双层底油轮搁浅于台型礁石的事故场景,通过对船底构件结构损伤机理的分析,提出一套结合船底结构损伤程度推算方法和Smith方法,评估损伤后船体剩余极限强度的解析计算预报方法。研究中应用数值仿真技术,模拟了船舶搁浅过程中的结构损伤及搁浅后船体极限承载过程,并与解析预报方法的结果进行了对比。结果表明,文中提出的对搁浅损伤后船舶剩余强度的解析预报方法准确性较好,对船舶双层底耐撞性结构设计和安全性评估都有一定的指导意义。     

基于全耦合技术的船体结构碰撞性能研究

由于船舶碰撞问题的复杂性,通常是将船舶碰撞的外部机理与内部机理分开研究。作者基于“全耦合”分析技术,建立撞击船与被撞船整船模型,成功解决了船体与流场、撞击船与被撞船的耦合。此外,考虑撞击船与被撞船同步损伤,将内部机理同外部机理同步分析。通过数值仿真计算,分析了碰撞后撞击船与被撞船的运动、能量转化以及碰撞力、损伤变形及各构件的吸能情况。另外,开展多种碰撞工况计算研究,得出了便于工程应用的极限撞速曲线,为后续的船舶碰撞研究提供了技术支撑。     

典型加筋板拉伸疲劳试验方法

加筋板是船体结构的主要组成部分,针对船用加筋板试件在疲劳试验过程中连接段先于考核段破坏的技术问题,文章开展了加筋板拉伸疲劳试验技术研究,提出了加筋板拉伸疲劳试件设计方法。在此基础上,依据疲劳累积损伤理论,结合声发射动态裂纹检测技术,建立了基于声发射技术的疲劳累积损伤试验方法。通过加筋板拉伸疲劳试验验证了该方法的可行性和适用性,实现了疲劳试验的考核目标,可为以后类似结构疲劳试验提供方法参考。     

基于贝叶斯网络的车辆目标功能毁伤评估模型

应用贝叶斯网络在解决不确定性事件方面的推理优势,根据车辆目标的毁伤特征分析建立了贝叶斯网络功能毁伤评估模型。在目标物理毁伤信息分析的基础上,通过实例演示了评估过程,验证了用贝叶斯网络进行功能毁伤评估的可行性与有效性。     

Using a SVM to evaluate damage to vibration isolators in an elastic raft system

Predicting damage to vibration isolators in a raft experiencing heavy shock loadings from explosions is an important task when designing a raft system. It is also vital to be able to research the vulnerability of heavily shocked floating rafts unreliable, especially when the allowable values The conventional approach to prediction has been or ultimate values of vibration isolators of supposedly uniform standard in a raft actually have differing and uncertain values due to defective workmanship. A new model for predicting damage to vibration isolators in a shocked floating raft system is presented in this paper. It is based on a support vector machine（SVM）, which uses Artificial Intelligence to characterize complicated nonlinear mapping between the impacting environment and damage to the vibration isolators. The effectiveness of the new method for predicting damage was illustrated by numerical simulations, and shown to be effective when relevant parameters of the model were chosen reasonably. The effect determining parameters, including kernel function and penalty factors, has on prediction results is also discussed. It can be concluded that the SVM will probably become a valid tool to study damage or vulnerability in a shocked raft system.     

LPG船舷侧结构的碰撞性能研究

研究了LPG船舷侧结构碰撞损伤过程和多种构件的抗撞作用,通过分析发现,LPG船的舷侧耐撞力远远低于同吨位的常规单壳船。LPG船的强肋骨在抵抗碰撞中起主要作用,由此提出提高常规LPG船舷侧结构提高耐撞力的最佳途径。     

铁路客车轮对踏面硌伤自动分析系统的研究与实现

为了解决客车轮对踏面硌伤人工分析效率低且质量不高的问题,基于大数据关联分析技术,构建了一套硌伤自动分析系统.从硌伤排查、自动分析、故障定位、统计分析4个方面分析系统的主要组成和功能,探讨了实现系统的关键技术.系统的应用提高了对客车轮对踏面硌伤分析和故障排查的效率.     

基于客户关联的纯电动轻卡驱动电机可靠性台架试验研究

为研究轻卡BEV驱动电机可靠性台架试验标准与实际客户的关联,文章基于整车CAN网络,采集实际客户日常行驶过程中的电机扭矩、转速等数据,通过Ncode软件计算出电机的扭矩谱。根据Miner准则,计算出电机20万公里的疲劳伪损伤。对比电机可靠性台架试验的电机伪损伤,确定电机台架试验标准是否满足客户需求。     

鱼雷攻击潜艇的毁伤效果评估模型研究

客观、准确地评价鱼雷攻击潜艇的毁伤效果是鱼雷与潜艇对抗的最后一环,也是评价鱼雷武器系统作战效能的重要指标。本文在现有毁伤概率计算方法的基础上引进了舱段的毁伤程度、要害指数、命中概率、毁伤效果累积系数和齐射毁伤系数等参数,建立了一种比较全面的用来评价鱼雷攻击潜艇毁伤效果的数学模型,并给出了典型应用。