有机锗多酸衍生物对S_(180)肿瘤细胞DNA合成的抑制作用

目的　探讨有机锗多酸衍生物对S1 80 肿瘤细胞DNA合成的抑制作用。方法　用3H TdR掺入法检测有机锗多酸衍生物在体外对S1 80 肿瘤细胞DNA合成的抑制作用 ,观察不同剂量有机锗多酸衍生物对S1 80 实体瘤的抑制作用和对免疫器官的影响。结果　体外实验表明 ,有机锗多酸衍生物对S1 80 细胞的生长具有明显的抑制作用 ,而且浓度越高 ,抑制作用越强。体内实验也表明 ,有机锗多酸衍生物对S1 80 实体瘤的生长具有抑制作用 ,而且剂量越大 ,抑制作用越强。且有机锗多酸衍生物可防止荷瘤鼠脾脏重量的下降。结论　有机锗多酸衍生物可抑制肿瘤细胞生长 ,并存在剂量依赖关系     

Mannich反应制取的SPN衍生物的摩擦学研究

通过Mannich合成了一种含苄胺的SPN衍生物,在四球摩擦磨损试验机上研究了它们作为加氢油添加剂的摩擦学性能.实验结果表明,该类化合物能较好地提高基础油的极压抗磨性能.用X-射线光电子能谱(XPS)分析了钢球磨损表面典型元素的化学状态,结果表明,在摩擦过程中,钢球表面形成了一层合硫,磷无机膜和含氮有机膜组成的复合膜,...     

Application of a self-tuning fuzzy PI–PD controller in an active anti-roll bar system for a passenger car

A fuzzy proportional-integral-derivative (PID) controller has not been widely investigated for active anti-roll bar (AARB) application due to its unspecific mathematical analysis and the derivative kick problem. This paper briefly explains how the derivative kick problem arises due to the nature of the PID controller as well as the conventional fuzzy PID controller in association with an AARB. There are two types of controllers proposed in this paper: self-tuning fuzzy proportional-integral–proportional-derivative (STF PI–PD) and PI–PD-type fuzzy controller. Literature reveals that the PI–PD configuration can avoid the derivative kick, unlike the standard PID configuration used in fuzzy PID controllers. STF PI–PD is a new controller proposed and presented in this paper, while the PI–PD-type fuzzy controller was developed by other researchers for robotics and automation applications. Some modifications were made on these controllers in order to make them work with an AARB system. The performances of these controllers were evaluated through a series of handling tests using a full car model simulated in MATLAB Simulink. The simulation results were compared with the performance of a passive anti-roll bar and the conventional fuzzy PID controller in order to show improvements and practicality of the proposed controllers. Roll angle signal was used as input for all the controllers. It is found that the STF PI–PD controller is able to suppress the derivative kick problem but could not reduce the roll motion as much as the conventional fuzzy PID would. However, the PI–PD-type fuzzy controller outperforms the rest by improving ride and handling of a simulated passenger car significantly.     

基于模糊控制的隧道有害气体治理技术研究

针对隧道通风系统控制手段单一、控制滞后、效率低且效果差等问题，改进一种基于模糊理论的多种有害气体综合治理新方法，并采用模糊PID控制技术构建一种综合治理系统。该系统利用采样模块实时监测数据，将信号上传至分析模块进行全局把控，通过模糊控制模块在线校正参数，不断循环控制变频器来提高被控对象的运行频率，调节风量与吸收液喷雾量，最后由治理模块实施通风稀释和喷雾净化，实现对多种有害气体进行治理。该系统应用于青海省某穿煤隧道，结果表明： 该系统能够快速降低放炮后监测断面处有害气体浓度，其中掌子面处瓦斯、硫化氢的平均浓度值分别降低了17.3%、27.3%，衬砌前端处二者的平均浓度降低了12.2%、36.7%，具有较高的准确性；放炮后浓度降至规范限值的时间也由平均20 min减少至10 min左右，缩短了1~2倍，能有效保障隧道施工安全，提高隧道施工效率。     

不确定气动干扰效应影响下并列大跨度桥梁颤振导数识别方法

将处于自然风中一前一后并列布置的大跨度桥梁相互之间可能存在的不确定相互气动干扰处理成随机气动干扰,并归入到紊流风随机激励中,采用基于模态参数识别的随机子空间识别方法,开发了桥梁断面颤振导数识别的专用程序,并以具有理论解的Theodorsen平板为例,通过系统响应数值仿真和颤振导数识别,验证了该方法的可靠性。针对实际大跨度桥梁,设计了并列节段模型试验悬挂系统,开展了紊流风和随机气动干扰效应下的并列大跨度桥梁节段模型风洞试验,将迎风、背风侧桥梁断面的颤振导数结果与均匀流、紊流风中单个桥梁断面颤振导数值进行了对比。结果表明:背风侧桥梁对迎风侧桥梁的颤振导数影响很小,而迎风侧桥梁对背风侧桥梁的颤振导数有较大影响;该研究方法为存在这种随机气动干扰的并列大跨度桥梁颤振导数识别提供了一个较为合理的途径。     

Level and attitude control of the active suspension system with integral and derivative action

A 7-DOF full-car model with optimal active control suspension is utilized to evaluate the vehicle dynamic performances which are achieved through proposed controllers. The optimal controller, which includes the integral action for the suspension deflection, considerably improves the attitude control of a vehicle because the rolling and pitching motion in cornering and braking maneuvers are reduced, respectively. In the viewpoint of level control, the integral control acting on the suspension deflection results in the zero steady-state deflection in response to static body forces and ramp road input. The dynamic characteristics of the suspension control system are evaluated in terms of time domain and frequency domain. The simulations in the time domain demonstrate the advantages of the active suspension system obtained by penalizing the integral and derivative of suspension deflections and the derivative of roll and pitch angles in the performance index. The frequency characteristic curves obtained by simulations regarding integral action or derivative action show the increase of both ride comfort and road-holding performances by maximizing the use of suspension deflections. The potential of derivative control is shown by the performances of the car traveling over a bump and braking.     

苯并三氮唑醇衍生物的摩擦学性能研究

合成了一种新型无硫磷苯并三氮唑醇衍生物（EBP）,在四球摩擦磨损试验机上研究了它们作为加氢油添加剂的摩擦学性能．实验结果表明,该添加剂具有良好的摩擦学性能,是一类新型无硫磷环保型润滑油添加荆．用扫描电镜（SEM）分析了钢球磨损表面形貌和元素面分布,结果表明,在摩擦过程中,钢球表面形成了一层含氮、氧膜,这层膜能提高基础油的摩擦性性能．     

近地、水面时的飞行器动态稳定特性数值模拟

基于非结构动态网格重构技术,采用SA模型以及VOF方法,分别对NACA0012二维翼型自由空间、近地效应以及近水面效应的非定常运动流场进行了数值计算分析,并根据建立的基于小幅度强迫振动的组合动导数辨识方法计算了各个攻角下动导数。计算结果分析表明动导数计算方法准确可靠;中小攻角下,地面与水面以管道效应影响流场,均损失了动态阻尼,柔性的水面损失更多,动导数绝对值更小;大攻角时,两者表现为阻塞效应,柔性水面下的动态阻尼增大,动导数绝对值也变大;相比地面效应,柔性的水面影响范围更广。     

桥梁风振试验颤振导数识别的Ibrahim时域优化研究

基于R.H.Scanlan提出的自由振动法求解桥梁颤振导数实验量很大,且在提取交叉导数的过程中,一方面要求模型的竖向运动和扭转运动在所有的风速下都具有相同的频率比和阻尼比是很难达到的,另一方面非耦合导数的识别误差将带到耦合导数中.文中基于Ibrahim时域的改进方法,应用变尺度优化算法进行提取桥梁断面的全部颤振导数,研究结果表明应用此方法来解决非线性参数辨识问题比最小二乘法好.     

山区航道水流流路规律研究

通过对西南地区山区河流实测资料进行分析整理 ,总结出 :正弦派生曲线水流线路、协调的水流方向、良好的水流转向角及较大的弯曲半径为理想的航道水流流路 ,并提出了该规律在工程设计中的应用