预缺血对培养乳鼠心肌细胞缺血再灌注损伤的延迟保护作用

观察了预缺血对培养乳鼠心肌细胞缺血再灌注损伤的影响。结果发现,经预缺血诱导的,Ｃ肌细胞超氧化物歧化酶（ＳＯＤ）活性升高,与缺血再灌注组（Ｉ－Ｒ）比较,经典预适应组（ＣＰＣ）和延迟预适应组（ＬＰＣ）乳酸脱氢酶（ＬＤＨ）释放减少,心肌细胞存活率升高,脂质过氧化减轻,膜流动性增加。提示：培养乳鼠心肌细胞存在延迟预适应,其机制与预缺血提高心肌细胞抗氧化酶的活性、增加缺血再灌注时自由基的清除有关。     

粘附分子E-Cadherin和CD_(44v6)表达与肺癌淋巴转移的关系

目的 探讨粘附分子E－Cadherin和CD44v6与肺癌淋巴转移的关系。方法 采用免疫组化SP法检测了63例肺癌组织及其中41例淋巴转移灶中E-Cadherin和CD４４v6的表达。结果 淋巴转移灶中CD４４v6阳性表达率为85..37%,显著高于原发灶(63..49%,P＜0..05);ECadherin和CD４４v6均与肺癌淋巴转移密切相关(P值分别小于0..05和0..001);诊断肺癌淋巴转移的敏感度和特异度E-Cadherin异常表达为63..41%和63..64%,CD４４ｖ６阳性表达为85..37%和77..27%,平行试验敏感度为87..80%,特异度为59..09%,系列试验敏感度为60..98%,特异度为81..18%。结论 E-Cadherin异常表达和CD４４ｖ６阳性表达可能均在肺癌淋巴转移中起重要的促进作用,可作为诊断肺癌淋巴转移的辅助指标。     

THE CHARACTERISTICS OF ENDOGENOUS OUABAIN SECRETIONFROM CULTURED BOVINE ADRENOCORTICAL CELLS

Endogenousouabain(Eo)hasbeenconsideredasacirculatingfactorthatregulatesthebodyfluidvolumebalance,urinesodiumextractionandvaso-contrictivetone,whichplaysanimportantroleinpathogenesisofhypertensionandsomecardiovas-culardisorderst12.Sinceitwasdiscoveredandiden-tifiedbyHamlynin199lt,i,severallinesofevi-dencesindicatethattheadrenalcortexisthemajorsourceofEO.Thepurposeofthisstudyistocom-parethecharacteristicsofEOsecretionwiththewell-knownadrenocorticalhormonesaldosteroneandcortisol,determinetheeff…     

THE CYTOTOXIC EFFECTS OF CRUDE BILE ON HUMAN PANCREATIC CANCER CELL LINES

Thebileacidswereconfirmedasnonspecificcytotoxicsubstanceswhichplayveryimportantro1einpathophysiologyofextrahepaticcholesta-sis[la.Invitrostudieshadprovedthatthebileacidscouldcausechronicandacuteinjuryofpancreaticductalepitheliumactingasaninitiatorofpancre-atitist2i.Thepancreaticcancerisamajorworld-widepublichealthproblernandremainsasignifi-cantclinica1challenge.Atthetimeofdiagnosis,about7o%ofpancreaticcancerpatientsmanifestobstructivejaundicewhichcanresultinprogressiveliverdysfunctionandculmin…     

EXPRESSIONS OF P53, PROLIFERATING CELL NUCLEAR ANITIGEN, BCL-2 PROTEIN AND THEIR SIGNIFICANCE IN SALIVARY ADENOID CYSTIC CARCINOMA

Studiesonthecarcinomasshowedthatthespeedofcarcinomadevelopmentisdependentonthebalanceofcellproliferatingandapoptosis.Soitisveryimportanttostudythemechanismbywhichoncogenescontrolproliferationandapoptosisoftu-morcell.Moststudiesonsalivaryglandtumorshavelaidemphsisontheproliferatingfunctionofonco-genesathomeandabroad,andignoranteditsfunc-tiononapoptosis,especially,thestudieswerefew-.erincombiningtwokindsoffunction.Helen's[13studyonACCindicatedthatmutationofP,3doesn'tplayimportantroleincarcinog…     

褪黑素对链脲佐菌素所致胰岛β细胞损伤的保护作用研究

用链脲佐菌素 (STZ)作用于离体胰岛β细胞 2 4 h,一氧化氮 (NO)、脂质过氧化产物丙二醛(MDA)生成增多 ,胰岛细胞膜流动性下降 ,微粘度增高 ,同时胰岛素分泌功能降低 ,细胞存活率下降。预先给高浓度褪黑素 (10 μmol/ L)处理 2 4 h者 ,可减少 NO、MDA的释放 ,提高超氧化物歧化酶的水平 ,使胰岛细胞的氧化损伤减轻 ,膜微粘度降低 ,膜流动性增加 ,细胞存活率显著提高。但低浓度褪黑素 (10 nmol/ L)无此作用。提示高浓度褪黑素对 STZ所致的胰岛 β细胞损伤有一定的保护作用。     

Two Models of DMFC under Effects of Cathode Humidification Temperature and Anode Flow Rate

This paper introduced a novel self-adjustment of parameters of fuzzy neural networks. Then, the effects of cathode humidification temperature and anode flow rate on the performance of direct methanol fuel celI（DMFC） were described respectively. Two dynamic performance models of DMFC under the influences of cathode humidification temperature and anode flow rate were established separately based on fuzzy neural networks. The simulation results show the accuracy of the models established is satisfactory.     

质子交换膜燃料电池车载系统智能控制算法研究

介绍了质子交换膜燃料电池(PEMFC)车载系统的智能控制算法。由于汽车行驶过程中对功率需求的随机性,使得该系统成为一个变输入变输出系统,对控制的实时性有较高的要求。为此,该系统引入仿人智能控制,并取得了良好的控制效果。     

直接甲醇燃料电池在汽车上的应用前景分析

介绍了直接甲醇燃料电池的结构、工作原理和特性,对影响其应用于汽车的两个主要因素———燃料转换效率和功率密度进行了详细地分析,对目前面临的主要技术难题和解决方法进行了阐述,如催化剂和甲醇渗透等,最后得出了一些相应的结论。     

车用可插拔式燃料电池增程器匹配设计研究

为一款正在开发的燃料电池增程式微型电动车,提出了可插拔式燃料电池增程器/蓄电池动力系统的方案和系统关键部件,如燃料电池、DC/DC转换器等的选型原则和匹配设计方法;为在仿真中考虑排氢动作对风冷自增湿燃料电池耗氢量的影响,提出了瞬时氢气过量系数查表法;最后,利用M atlab/Cru ise联合仿真平台对匹配设计结果进行了验证。