Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

健胃愈疡颗粒对慢性胃炎伴幽门螺杆菌感染胃黏膜PAF、PS2的表达及对上皮细胞凋亡的影响

目的观察健胃愈疡颗粒(JWYY)对幽门螺杆菌相关性胃炎胃黏膜乳癌相关肽(PS2)和血小板活化因子(plate-let activating factor,PAF)表达的变化,并分析其可能的作用机制。方法80例幽门螺杆菌感染慢性胃炎患者随机分为2组,治疗组42例给予健胃愈疡颗粒治疗,对照组38例给予西药三联药物治疗。应用胃镜下活检胃黏膜组织快速尿素酶和Warthin-Starry染色法检测幽门螺杆菌,应用Western blot检测PS2、PAF表达变化。应用末端转移酶介导的dUTP切口末段标记法(TUNEL)检测细胞凋亡。第4周复查胃镜。结果治疗组凋亡指数明显比对照组减少(P<0.05),治疗组总有效率高于对照组(P<0.05)。Western blot检测显示:JWYY颗粒可上调PS2并下调PAF的表达,而对照组对胃黏膜PS2和PAF的表达影响不大。结论健胃愈疡颗粒治疗幽门螺杆菌(Hp)相关性胃炎可能与杀灭Hp、上调PS2和下调PAF的表达来抑制细胞凋亡有关。     

基于产业转移的中国汽车产业战略研究

通过对世界汽车产业四次转移的阐述,分析了世界汽车产业转移的原因与特点,认为我国面临着承接世界汽车产业第四次转移的历史性机遇,提出我国汽车产业发展的战略目标：利用20年左右时间,把我国建设成为继美、欧、日之后的第四个世界汽车产业中心。     

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中医理论的经济学应用初探

简述了中医精气神学说,结合经济学知识提出了企业的精气神概念;对企业主要职能部门作了五行分形,利用五行相生相克分析了各功能区的相互依存与制约关系.     

时速350 km中国标准动车组车载天线的隔离度及最小排布间距

基于中国标准动车组车载终端设备的部署现状和未来规划,调研其采用的通信系统类型、车载天线的工作频率和安装数量;以900MHz频段GSM-R系统、450MHz频段和2 100MHz频段LTE-R系统为例,对车载终端的杂散干扰进行理论分析,基于自由空间损耗理论模型计算、电磁软件仿真模拟和试验平台实测的结果,研究车载天线的隔离...     

A Delphi analysis on green performance evaluation indices for ports in China

This study identified a set of applicable and practical green performance evaluation indices for Chinese ports using the Delphi technique. The research was conducted by targeting three representative Chinese ports in Eastern China: the Shanghai Port, Ningbo Port, and Qingdao Port. An effective expert panel was structured with direct stakeholders related to green performance, which was based on a sufficient consideration of the unique and the special decision-making system for Chinese ports. Twenty-one green performance indices in six dimensions (i.e. liquid pollution management, air pollution management, noise control, low carbon regulations and energy savings, marine biology preservation, and organization and management) were eventually identified through three rounds of iterations. The identified green performance indices for Chinese ports are highly consistent with the Chinese Government’s environmental policies. Compared with European ports, the green port performance indicators in China are not as comprehensive. The indicators that are strictly consistent with national macro policies and the factors that are more easily seen, heard, and felt were perceived to be more important. From an academic perspective, this study offers a new approach for system establishment and green practice criteria exploration and thus provides a significant basis for further green port studies.     

金融危机对中国航运业及中国海事的影响之追踪

文中以广州南沙港区为例,通过大量的数据分析,讨论了金融危机对中国航运业所带来的冲击,以及对中国海事监管造成的影响。建议在当前形势下,中国航运业和中国海事都要紧紧抓住危机中蕴含的机遇,谋发展、求提升。     

应答器报文在CTCS中的定义与应用

列车运行控制系统的应用已经比较普遍,各种速度的铁路都有运用,但在高速铁路上的应用更能显示出其高水平和具有代表性。高速铁路正在欧洲和亚洲快速发展,已通车或正在建设中的高速线路多达十几条,这对于推动一个国家的经济发展有着深刻的影响。尽管各高速铁路采用的列车运行控制系统都不尽相同,但它们却有着基本相似的工作原理,扼要阐述列控中心的工作原理,并对高速列车运行的控制信息——报文做进一步举例说明。     

汉英名词形态标记比较与翻译

汉英名词形态标记差异悬殊,这种语言形式的差异是汉英名族文化差异的具体体现。汉民族倾向于具体形象思维,语言形象具体,"动"感十足;而英语民族擅长抽象思维表达,英语语言具有"静"态性,行文灵活,表达自然,但也抽象晦涩难以理解。汉英语转换要充分考虑各自文化差异,分别体现汉英语的"动"态与"静"态。