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Different fromthe biallelic expression mannerof most common autosomal genes,i mprinting is aspecial genomic expression phenomenon,of whichthe i mprinted genes show parental-specific expres-sion only according to their parental origin[1].Cor-rect i mprintingis i mportant inthe nor mal embryon-ic development,postnatal growth,as well as behav-ior of ani mals.Dysregulation of i mprinting hasbeen i mplicated in the pathogenesis of congenitaldiseases and cancer[2-3].To date,78kinds of mousei mprinte… 相似文献
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对西安-宝鸡提速区段接触网线岔存在的问题进行了分析,结合提速区段现场运营接触网线岔检测的各种技术数据,对提速区段接触网线岔的变化规律进行了论述和探讨,并提出了提速区段接触网线岔检调的一些措施和建议。 相似文献
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The coastal zone has critical natural, commercial, recreational, ecological, industrial, and esthetic values for current and future generations. Thus, there are increasing pressures from population growth and coastal land development. Local coastal land use planning plays an important role in implementing the U.S. Coastal Zone Management Act (CZMA) by establishing goals and performance policies for addressing critical coastal issues. This study extends the CZMA Performance Measurement System from the national level to the local land use level by measuring coastal zone land use plan quality and political context in fifty-three Pacific coastal counties. Plan quality is measured using an evaluation protocol defined by five components and sixty-eight indicators. The results indicate a reasonable correspondence between national goals and local coastal zone land use planning goals, but a slight gap might exist between the national/state versus local levels in the overall effectiveness of coastal zone management (CZM) efforts. The results show many U.S. Pacific coastal counties lack strong coastal zone land use plans because the average plan quality score was only 22.7 out of 50 points. Although these plans set relatively clear goals and objectives, they are somewhat weaker in their factual basis, identify a limited range of the available planning tools and techniques, and establish few coordination and implementation mechanisms. The regression analysis results indicate that CZM plan quality was not significantly related to any of the jurisdictional characteristics. 相似文献
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目的以人单核细胞株U937为研究对象,观察在氧化修饰低密度脂蛋白(oxLDL)刺激下U937细胞清道夫受体AⅠ(SR-AⅠ)和ATP结合盒转运体A1(ABCA1)mRNA的表达情况。方法以不同质量浓度的oxLDL(0、25、50、75、100、125 mg/L)与U937细胞共同培养48 h,然后进行油红O染色以了解其胞内脂质含量,同时用实时荧光定量PCR方法检测其ABCA1和SR-AⅠmRNA的表达量。结果单核细胞ABCA1和SR-AⅠmRNA在无oxLDL干预下其表达最低;oxLDL可诱导ABCA1和SR-AⅠmRNA的表达,与无oxLDL干预组比较差异有统计学意义(P均<0.01);ABCA1 mRNA在50 mg/L oxLDL干预下表达最强,其后随着oxLDL培养浓度的增加其表达反而下降;SR-AⅠmRNA表达为逐渐增高,50 mg/L oxLDL干预时表达最强。结论 U937细胞随着oxLDL干预浓度的提高其ABCAl mRNA和SR-AⅠmRNA表达呈先增高后降低的趋势,在50 mg/L oxLDL时表达最高;二者在泡沫细胞形成过程中起着非常重要的作用。 相似文献
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从运输需求、装备配套发展、现代信息技术研究方面,探讨了美军运输技术装备发展的做法和特点,结合我军实际,提出了转变观念、创新理论,注重借鉴、适时引进,自主创新、技术赶超,寓军于民、军地结合,夯实基础、配套改造,优化配置、系统集成等有针对性的建议,以期对我军军交运输保障装备建设有所启示。 相似文献
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介绍一汽丰田卡罗拉轿车采用的U341E型电控自动变速器电控系统的组成、电路;阐述电控系统信号输入输出数据特点;分析电控系统的控制原理。 相似文献
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结合江东路部分节点改造工程,针对EPS轻质路堤断面设计形式及其防护措施,通过分析传统方法的不足,提出了轻型EPS联合轻型U槽的横断面设计形式。实践证明,该方案可以从根本上解决附加荷载大的问题.同时减少差异沉降,防止横向裂缝等,值得推广。 相似文献
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