Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

从水质水量联合角度评价鉴江流域可用水资源量

首先介绍满足流域水功能区水质目标的可用水资源量联合评价方法。该方法通过水量平衡和污染物质的质量平衡原理,建立单元系统的水量水质模型,依据水质水量资料确定模型参数;然后利用模型推求单元系统的可用水资源量;最后推广应用到河流多区段系统。将该评价方法应用到广东鉴江流域,计算该流域的可用水资源量。结果表明,可用水资源量与水质污染现状、水功能区的水质目标、河道生态需水量等有关。     

不确定多时滞线性系统的稳定性

对于多参数扰动下的多时滞线性系统，构造二次型加积分项的Lyapunov泛函，导出了系统鲁棒稳定的时滞独立准则，由于利用了不确定性的结构特点，该准则给出的时滞独立扰动界关于参数空间的原点可以是非对称的，扩大了系统的稳定参数域，给出了所得结果的数值算例，并与已有的结果作了比较。     

关联效应对CaCuO2的电荷与自旋密度分布的影响

采用杂化密度泛函方法和哈垂一福克方法对CaCuO2的电荷与自旋密度的分布进行了研究．CuO2层的电子结构具有明显的二维特征．电子间的关联效应使Cu离子的自旋极化被削弱的同时，增强了O离子的自旋极化效应．     

Statistical Approaches to Mapping QTL of Dynamic Traits

Dynamic traits are those that change with timein the development process of life or other quanti-tative factor (e. g. environmental condition).These traits also are called infinite-dimensionalcharacters by Kirkpatrick and Heckman[1]andfunction-valued traits by Pletcher and Geyer[2], be-cause they can be expressed as a function of someindependent and continuous variables. Dynamictraits are collected at many time points during thecourse of life. Therefore, studies of dynamic traitsare regarded…     

山区双车道公路驾驶员疲劳特性研究

山区双车道公路由于地形条件限制线形复杂多变,山体及路侧植被遮挡视线的现象时有发生,增加了驾驶操作的难度和强度.导致驾驶操作频繁、精神紧张.长时间高强度、大负荷的驾驶操作极易产生驾驶疲劳,进而发生交通事故.因此,研究山区双车道公路驾驶员的驾驶疲劳特性,可为山区公路的交通安全设计和管理提供参考,预防交通事故,保证人车安全.     

高速公路雾区监控系统功能设计初探

高速公路雾区的交通安全是一个世界性的问题,每年由雾引发的交通事故导致的经济损失是十分巨大的。因此,提高高速公路在雾天低能见度条件下的交通安全水平,保证运输的畅通、安全具有极其重要的经济和社会效益,其中一个重要的方面就是高速公路的监控系统。针对雾对高速公路交通安全的影响机理,分析驾驶员的服务需求,对雾区高速公路监控系统的功能设计进行了初步探讨。     

Calculation of VPP basing on functional analyzing method

VPP can be used to deter mine the maxi mumvelocities of a sailboard at various sailing-routes,byestablishing the forces and moments balance-equa-tions on the sail and board in accordance with theprinciple of the maxi mal drive-force.Selectingroute is the most i mportant issue in upwind-sailing,and VPP calculations could provide the basis for de-ter mining the opti mal routes.VPP calculation of the sailboard perfor mance isa complex and difficult research task,and there arefew projects in thi…     

玄武岩纤维（BFRP）筋与混凝土粘结性能试验研究

玄武岩纤维筋是一种新型的复合材料,具有强度高、耐腐蚀等特点,用它代替混凝土路面结构中的钢筋,可解决因雨水进入引起的连续配筋混凝土路面钢筋锈蚀问题。玄武岩纤维筋与混凝土的粘结性能,是影响其推广应用的关键技术之一。本文运用18个中心拉拔试件研究了不同螺纹表面玄武岩纤维筋与混凝土之间的粘结性能,试验结果表明：玄武岩纤维筋与混凝土试验粘结强度在11.592～23.578MPa之间,粘结强度随着玄武岩纤维筋表面螺纹深度与螺纹间距的变化而变化;有螺纹玄武岩纤维筋的粘结强度明显高于无螺纹玄武岩纤维筋,玄武岩纤维筋最佳螺纹间距约为筋直径长度的80%,最佳螺纹深度约为直径长度的10%;拉拔试件的破坏形态均为玄武岩纤维筋与混凝土接触面混凝土的剪切破坏而拔出。     

快速公交系统在我国城市中的功能定位分析

快速公交集容量大、速度快、系统造价低等优点于一身,近年来在我国各地得到了广泛的应用。在分析快速公交的特点和大、中、小城市交通现状的基础上,研究快速公交在城市中的功能定位,可为我国城市快速公交系统的建设规划提供有益的参考。