京秦高速公路沥青路面病害养护方法效果评价

在养护工程实践中以最大限度提高道路使用性能为目的，不断应用新技术、新材料、新工艺．为保证全线道路的使用功能和通行能力起到了积极的作用。     

李子沟车站滑坡体治理研究

根据李子沟火车站工程及地层地质特点,介绍了采用加强排水设施、削坡减载、挤密碎石桩、高压粉喷桩加固处理、设计抗滑桩等综合治理李子沟滑坡体的措施,解决了本区域的流坍现象,为类似工程施工提供借鉴。     

奉节长江大桥南桥头高边坡治理

重庆市奉节长江大桥地处齐曜山山脉构造带,断裂褶皱发育,地形陡峻,地质条件复杂,不良地质作用发育,南桥头交叉道口人工边坡高达140 m.经过多方案比较论证,采用了多种措施对边坡进行综合处治,变形监测结果表明治理后边坡处于稳定状态.     

The β-amyloid protein induces S100β expression in rat hippocampus through a mechanism that involves IL-1

Objective To explore the effect of β-amyloid protein (Aβ) on S100β expression in rat hippocampus and its mechanisms. Methods At 7 days after bilateral stereotaxis injection of different dose of fibrillar Aβ 25-35 and interluekin-1 receptor antagonist (IL-1ra) into the rat CA1 region, the learning and memory abilities of rats were tested with passive avoidance task. Amyloid deposition was detected by using Congo red staining technique. Nissl staining and immunohistochemical techniques were used to analyze the number of neurons, and GFAP and the S100β expression in hippocampal CA1 region , respectively. Results After fibrillar Aβ injection, the step-through latency of rats was significantly shortened compared to that of the control group. The GFAP positive astrocytes were found surrounding amyloid deposition. Neuronal loss occurred in the pyramidal cell layer of CA1 region. The number of S100β positive cells in Aβ-treated group was significantly increased compared with that in the control group. After IL-1ra injection, the number of S100β positive cells was significantly decreased. Conclusion Intrahippocampal injection of Aβ 25-35 could cause similar pathologic changes of Alzheimer's disease. Aβ 25-35 was capable of up-regulating S100β expression in a dose-dependent manner. The injection of IL-1ra could attenuate the effect of Aβ on S100β expression.     

OCCURRENCE CHARACTERISTIC OF KASHIN-BECK DISEASE BASED ON NUCLEAR FAMILY PEDIGREES

Kashin Beckdisease (KBD )isanendemicos teochondropathyresultingfromimpairedendochon drialdevelopmentinchildren .Itmanifestswithsecondarychronicdeformitiesandosteoarthrosisinadults.Geographically ,thediseaseoccursmainlyinadiagonalbeltrangingfromthenortheasttothesouthwestofChina (KBDarea) .Thisareaischar acterizedbyalowfoodseleniumcontent .Thereare2 .5millionpatientswithKBDand 30millionpeo pleareatrisk[1] .TheclinicalmanifestationsofKBDareflexionoftheterminalpartofthefingersorcrookedfinger…     

桥头跳车的病害原因及防治措施

较详细的分析了桥头跳车病害产生的的原因,并提出了相应的防治措施。     

上皮型钙粘附蛋白和层粘连蛋白在妊娠滋养细胞疾病中的表达及意义

目的探讨上皮型钙粘附蛋白(E-cad)和层粘连蛋白(LN)在妊娠滋养细胞疾病(GTD)中的表达及意义。方法应用免疫组织化学(SP法)检测74例GTD中E-cad和LN的表达情况。结果在GTD中,E-cad的正常表达率和LN强表达率分别为37.8%(28/74)和64.86%(48/74),显著低于正常绒毛组织。在葡萄胎(HM)、侵蚀性葡萄胎(IM)及绒毛膜癌(CC)中E-cad的正常表达率分别为53.3%、31.25%和16.67%;LN的强表达率分别为80%、56.25%和50%。随着GTD恶性程度的增加,E-cad的正常表达率及LN的强表达率逐渐降低,且与正常绒毛组织有显著差异。结论E-cad及LN的表达与GTD的发生、恶变及侵袭有关系;对E-cad与LN表达的监测有助于预测GTD的发展趋势及提示治疗效果。     

D6AC超高强钢的细丝双弧焊接工艺试验研究

分析了D6AC超高强钢的焊接性，采用细丝双弧焊接方法，进行D6AC超高强钢的双弧焊接工艺试验研究。采用细丝双弧焊接技术，基本可以解决D6AC超高强钢焊接时存在高裂纹倾向的问题，并降低焊接成本，避免了脉冲TIG焊扫法的低效率和高能密度焊接方法的高成本问题。     

高速列车开行方案研究

对高速列车停站影响进行了分析，建立了高速列车开行主案的多目标０－１规划数学模型，研究了一套有效可行的多层次０－１规划模型，这用有序组全树方法对问题求解。     

连续性血液净化枸橼酸体外抗凝技术在高危出血患者中的应用

目的研究枸橼酸体外抗凝技术行连续性血液净化(continuous blood purification,CBP)的抗凝效果,解决高危出血倾向患者需行CBP时抗凝难的问题。方法32例高危出血倾向患者随机分为A、B两组,每组16例。均行CBP治疗,均采用枸橼酸抗凝剂为碱基的置换液。A组患者置换液输注速度为2 000 mL/h,血流量200 mL/min,枸橼酸浓度为13.3 mmol/L;B组置换液输注速度为4 000 mL/h,血流量250 mL/min,枸橼酸浓度为7 mmol/L。通过外周静脉补充钙剂。监测患者每日治疗前及结束时全血活化凝血时间(WBACT)、血气分析、血清离子钙及总钙水平。结果32例患者共行CBP治疗112次,总治疗时间1 238.3 h;置换液输入前WBACT与治疗前差异不显著,输入置换液后两组滤器后WBACT(s)较滤器前在2、4、6 h各时间点的延长均有显著性差异(P<0.01);治疗后患者碱剩余(BE)及pH无大幅度上升,无碱中毒出现;治疗前后血清总钙、离子钙水平无显著变化;不加重全身出血倾向,无其他严重不良反应。结论枸橼酸体外抗凝技术能解决高危出血倾向患者行CBP时抗凝难题。