Induction of animal model of Graves' disease in BALB/c mice

Objective To construct an animal model of Graves' disease (GD) by immunizing BALB/c mice with hM12 cells co-expressing major histocompatibility complex (MHC) class Ⅱ molecules and human thyrotropin receptor (TSHR) molecules. Methods BALB/c mice in experimental group (H-2d) were immunized with hM12 cells Intraper-itoncally every 2 weeks for six times, while mice in control group were immunized with M12 cells. Five weeks later, the thyroids were histologically examined, and serum samples were tested for thyroid-stimulating antibodies (TSAb) and thyroid hormone levels. Results One BALB/c mouse in experimental group developed Graves'-like disease. Total T4 and T3 levels in this mouse were above the upper limit of normal, TSAb activity was displayed in its serum. The thyroid histologically showed the features of thyroid hyperactivity including thyrocyte hypercellularity and colloid absorption.None of control mice developed Graves'-like disease. Conclusion An animal model with some characteristics of human Graves' disease was successfully induced and the model will facilitate studies aimed directly at understanding the patho-genesis of autoimmunity in Graves' disease.     

基于MC9S12DP256的汽车ABS模糊滑模控制器

对于ABS控制器的设计,在控制逻辑确定后,其设计难点在于控制器的软硬件实现。文章基于模糊滑模控制逻辑,介绍了基于Freescale公司HCS12系列16位单片机——MC9S12DP256的汽车ABS模糊滑模控制器的软硬件设计。硬件电路设计中,采用最小系统板和目标功能电路板分离设计的方法,基于最小系统开发板,设计了包括电源模块、输入调理及输出驱动电路的目标功能板;软件设计中,依据控制需求,采用模块化编程思想,给出程序流程图,描述了ABS控制系统的控制过程。指出该滑模控制器为后续的台架试验验证及轿车的主动安全控制装置的集成化研究打下了坚实的基础。     

Cr12MoV钢渗硼层脆性与耐磨性研究

采用粉末渗硼和膏剂渗硼对Cr12MoV钢进行表面改性,利用显微硬度法和划痕法声发射检测并分析了渗硼层表面脆性与敏感脆性,通过磨损试验对渗硼处理试样进行测试,并利用扫描电镜对试样磨损及磨痕形貌进行观察,研究了渗硼层的磨损机理。结果表明,Cr12MoV钢经渗硼处理后,渗硼层具有高硬度,并呈现一定的脆性,渗硼层的脆性属剥落脆性;Cr12MoV钢经渗硼后耐磨性有显著提高,渗硼层的脆性和硬度对耐磨性存在影响。     

集成USB Thumb驱动器的车载数据采集系统设计

介绍了一种先进的车载数据采集系统的设计方案。该系统采用片上集成全速USB 2.0接口的MC9S12UF32为核心,大容量NAND闪存芯片TC58DVM92A1FT00为存储介质,具有体积小、容量大、传输速度快的优点,已应用于某型电动汽车的数据采集中,工作稳定可靠,大幅提高了工作效率。     

Distributions of oxygen and carbon stable isotopes and CFC-12 in the water masses of the Southern Ocean at 30°E from South Africa to Antarctica: results of the CIVA1 cruise

This study presents oceanic distributions of stable isotopes (δ¹⁸O of water and δ¹³C of ΣCO₂) and CFC-12 from samples collected during the CIVA1 cruise (February/March 1993), across the Southern Ocean, along a meridian section at 30°E, from South Africa (44°S) to Antarctica (70°S). The isotopic measurements show important variations between the subantarctic surface waters with low δ¹⁸O–high δ¹³C values and the antarctic surface waters with very low δ¹⁸O–low δ¹³C values. The surface distributions of δ¹³C values follow the major frontal oceanic structures; the vertical distribution shows the progressive upwelling from the subantarctic zone to the antarctic divergence of ¹³C-depleted CO₂ derived from remineralization of organic matter. Along the Antarctic continental shelf, between 2500 and 4000 m, a core of water with δ¹⁸O values close to −0.1‰ is associated with a relative maximum in CFC-12 concentration, although this core is not detected by its temperature and salinity parameters. This water mass, which corresponds to recently formed deep water, may originate from the eastward extension of the Weddell gyre or from bottom waters coming from the East and formed near Prydz Bay.     

上海轨道交通12号线工程区间隧道设计优化

结合上海轨道交通12号线工程建设特点和难点,以在不影响既有桩基、建筑物安全的情况下保证盾构正常施工为目标,针对部分区间原线路设计方案、区间隧道衬砌结构设计方案、区间隧道盾构施工方案提出了优化方案并进行了论证;进而针对盾构下穿运营中的轨道交通区间隧道、密集建筑群提出了相应的施工技术措施,并在施工过程中严格控制施工质量。结果表明,优化方案实施效果良好,对邻近建筑物的影响均在允许范围内。     

上海轨道交通12号线通风空调系统设计

通风空调系统运行能耗巨大,其设计是城市轨道交通系统总体设计中的重中之重。基于相关标准和节能减排要求,确定了上海轨道交通12号线工程通风空调系统的运行模式,并对区间隧道(含辅助线)通风系统兼排烟系统、车站车轨区排热兼排烟系统、车站公共区通风空调系统、设备管理用房通风空调系统、空调冷源及水系统的设计进行了详细阐述。     

12 脉波逆变器快速变压变频控制新算法

提出了一种可实现快速变压变频的新型12脉波逆变器控制算法,以避免目前地铁辅助变流器采用三分频单边调节PWM控制方式进行相位调节时所引起的桥臂电流畸变和电压幅值调节较缓慢的问题。试验结果验证了该方法的有效性。     

TST12A地震反射波超前预报系统的应用

介绍了根据TSP的探测原理改进的TST12A地震反射波超前预报系统在梅子关隧道工程实例的应用情况,总结了TSP在应用过程中优点和不足之处,供设计人员和现场预报人员参考。     

十二相同步电动机对交-交变频调速系统谐波的改善

在给出十二相交-交变频器输出谐波电压的基础上,对交-交变频十二相同步电动机调速系统四"Y"综合d,q电压谐波进行了推导,结果表明,四"Y"d,q电压谐波可以互相抵消,使得d轴和谐波电压为零、q轴和谐波电压中仅含有幅值很小的少数次谐波,进一步对电流谐波、电磁转矩谐波的分析证明这种电压谐波抵消作用对改善交-交变频十二相同步电动机的谐波特性具有良好的效果.仿真和试验结果验证了理论推导的正确性.