Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

自动液位监控系统的设计

结合工业生产和生活中的实际问题,以STC89C52单片机为核心,通过外围硬件电路达到液位监控的目的.该系统主要是实时监测液位变化并进行显示输出.此外,系统在液位不满足要求的情况下,实现自动注水或放水,保证系统的水位在规定的范围内.本设计的液位显示通过LCD1602实现,液位测量部分使用了超声波测距模块,分辨率高,且为非接触式测量,抗干扰能力强.而对于液位的控制部分主要通过C语言编程来实现,同时增加了液位报警功能.     

软刚臂单点系泊装置监测预报系统的设计及实现

为进一步保障浮式生产储油装置(FPSO)的作业安全,通过海洋环境条件测量、FPSO运动和单点系泊系统(SPM)状态监测以及理论计算等手段,实现了软刚臂单点系泊监测预报系统的方案设计,并成功应用于渤海油田。经现场应用验证,该系统能够实现对FPSO及SPM运行情况的监测,为作业者提供FPSO操作指导及预警,有效的降低了作业风险。     

独柱墩-固定式防船撞装置波浪荷载研究

以跨海航道桥梁安全为背景,进行独柱墩及独柱墩-固定式防船撞装置结构波浪力研究。开展室内缩尺试验,验证并校准Fluent三维数值模型的准确性和有效性。利用最小二乘法分解墩柱水动力为Morison方程的形式,计算得到结构水动力系数。考虑波浪高度、波浪周期、防撞装置断面形状和大小等影响因素,计算并拟合出墩柱水动力系数与相关因素间的定量关系。研究结果表明：固定式防船撞装置的存在增大了墩柱表面所受波压强,但不改变其总体分布趋势。当防撞装置断面为矩形,且波浪高度较大时,装置对墩柱受力特性的影响最明显。墩柱结构所受水动力中惯性力占主导,且可用均匀分布的惯性力系数来代替实际分布,独柱墩-固定式防船撞装置结构上的惯性力系数可以达到2.1左右。     

一种单片机控制的水温测试系统

由于现代多样的电子控制技术和电子控制理论的迅猛发展,高精度的机械在各类工业控制系统、生产线等方面的需求越来越大.其中以单片机为核心实现的数字控制器,因其体积小、简便易行等优点,而被广泛应用于各行各业.本文将单片机的温度控制系统作为设计核心,通过温度传感器、单片机等软件系统图,并利用软件编程,从而达到实现水温控制的目的....     

京港澳高速武汉北喇叭形互通改扩建方案探讨

喇叭形立交为我国应用比例最高的基本型立交,受各控制因素制约,其改扩建难度较大。京港澳高速武汉北互通喇叭形立交改扩建充分利用现有工程,通过原址扩建升级立交功能,解决立交堵点。分析介绍了武汉北互通主线、G107扩建方式和远景交通量、用地等控制因素,探讨了根据实际控制因素及功能需求双喇叭立交的改扩建设计思路和具体方案。     

一种新型涡流测微仪的设计

在分析传统涡流传感器存在问题的基础上,介绍了一种新型的涡流测微仪,它以8031单片机 为核心,通过具体的软、硬件设计后,实现了数字式涡流传感器在较精密位移中的测量应用。实验结果 表明,这种涡流测微技术是行之有效的。     

Planning guidelines for metro–bus interchanges by means of a pedestrian microsimulation model

The big paradigm for cities nowadays is to study the movement of pedestrians at the interface between metro and bus systems – metro–bus interchanges. When these interchanges are not well designed, walking is inefficient and can be unsafe for pedestrians. This paper analyses, by means of a pedestrian microsimulation model, metro–bus interchange spaces in order to propose planning guidelines for the city of Santiago de Chile. Specific objectives are (1) to identify the variables that provide efficiency and safety in those spaces; (2) to simulate different scenarios using the pedestrian simulation model LEGION; (3) to propose planning and design guidelines for pedestrian spaces at metro–bus interchanges; and (4) to contrast the recommendations in the recently opened terminal station on Line 1 of Metro de Santiago: Los Dominicos Station.     

城市轨道交通换乘站布局综合评价方法研究

对城市轨道交通线网交会点是否需要设置为换乘站、换乘站设置对整体线网的优化有何影响、用什么标准衡量和评价换乘站的布局进行深入的研究。根据充分发挥线网整体效率、均衡客流强度、减少乘客无效乘距的指导思想,提出从网络发展水平、居民出行条件改善、运营效果三方面9项指标组成的轨道交通换乘站布局方案综合评价体系,研究指标量化的方法,对城市轨道交通换乘站布局进行多目标模糊综合分析评价。以某市轨道交通线网规划为例,应用评价体系推荐出最优布局方案。     

深圳地铁单程票流失算法研究

根据深圳地铁单程票流通特点,将运营中的单程票流失划分成两大类,并依据其在流通中的业务类型,通过卡信息记录集来确定流失种类。应用数据库知识和数据挖掘技术,提出这两类单程票流失的算法。