小儿肾病综合征红细胞膜电荷及血液流变学变化的研究

目的　探讨肾病综合征患儿蛋白尿的发生机制及其影响因素。方法　以红细胞 (RBC)膜Alcian蓝 (AB)结合量为指标观测 36例肾病综合征 (NS)患儿 RBC膜电荷量 ,并测定其血液流变学各指标。结果　 (1 )患儿 RBC膜 AB结合量明显降低 ,但其 RBC表面主要阴离子涎酸含量并未减少 ,提示 NS患儿 RBC膜电荷量呈“功能性”降低。 (2 )患儿全血粘度 (高切及低切 )、血浆粘度、血沉、红细胞压积、红细胞电泳时间、血沉方程 K值、红细胞聚集指数、全血还原比粘度等指标均明显增高 ,提示 NS患儿血液呈现高粘滞、高聚集、高浓缩状态。 (3)多元逐步回归分析结果提示 NS患儿尿蛋白量受 RBC膜电荷及血粘度的影响。结论　恢复肾小球电荷屏障功能、纠正血流变异常对于减少蛋白尿、改善血流状态、减少并发症、恢复肾功能具有重要意义     

ANALYSIS OF TYPE I AND TYPE Ⅱ CYTOKINES PROFILE OF LYMPHOCYTE IN PLEURAL EFFUSION OF NON SMALL CELL LUNG CANCER PATIENTS

Itis increasingly apparentthatthe main reasonforthe failure of anti- tumor immune response is theinactivation of TIL (Tumor Infiltrating Lympho-cyte,TIL) .The activation of immunocompetentcells is largely dependent on their local microenvi-ronment.Since the tumor local microenvironmentisthe frontier where host immunocompetent cells in-teract with the tumor cells directly,analyzing thetumor local microenvironment,especially compar-ing it to anti- inflammatory immune microenviron-ment,is very…     

THE EVALUATION OF LUNG CANCER PREVENTION IN BAOJI CITY OF SHAANXI PROVINCE OF CHINA

Recently,the mortality of lung cancerincreasesin many areas and countries,and lung cancer is be-coming the major disease in malignant tumour re-search.Baoji city was found to be one of the citieswith high lung cancer incidence in China in early1 970 s[1] . Thereafter,intervention measures havebeen adopted,such as establishing the Environmen-tal Monitoring Station in Baoji to control the pollu-tion of land,water and air,a number of workshopsand propaganda in cancer prevention,smoking- con-tro…     

Bcl-2和Bax蛋白表达与非小细胞肺癌临床病理特征的关系

目的　探讨 Bcl- 2和 Bax蛋白表达与非小细胞肺癌 (NSCLC)临床病理特征的关系。方法　应用免疫组化 SP法检测了 30例正常肺组织和 61例 NSCLC中 Bcl- 2和 Bax蛋白的表达。结果　 NSCLC组织中 Bcl- 2蛋白表达率 (57.38% )显著高于正常肺组织 (1 3.33% ) (P <0 .0 1 ) ,而NSCLC组织中 Bax蛋白表达率 (45.90 % )显著低于正常肺组织 (80 .0 0 % ) (P <0 .0 1 ) ,鳞癌和腺癌中 Bcl- 2和 Bax蛋白表达率均无显著差异 (P >0 .0 5) ,Bcl- 2蛋白表达率与 NSCLC病理分级及淋巴转移潜能呈正相关 (P <0 .0 5) ,与 P- TNM分期无关 (P >0 .0 5) ,Bax蛋白表达率与NSCLC病理分级、P- TNM分期及淋巴转移潜能呈负相关 (P <0 .0 1～ 0 .0 0 5) ,Bcl- 2和 Bax蛋白在 NSCL C中的表达呈负相关 (χ2 =9.93,P <0 .0 0 5)。结论　 Bcl- 2和 Bax蛋白相互抑制 ,均与 NSCLC发生、发展有关 ,可作为反映 NSCLC生物学行为的指标     

碳减排背景下氢燃料电池船舶发展现状及监管建议

为实现碳减排目标,航运业必须寻找更为清洁环保的船舶替代燃料,而零碳排放的氢能源电池将发挥巨大潜力.在介绍氢燃料电池船舶国内应用现状和技术规范基础上,分析氢燃料电池船舶的优势和面临的挑战,最后从海事管理机构的角度提出了对氢燃料电池船舶的监管建议.     

燃料电池和锂电池在船用领域的对比分析

本文首先比较燃料电池和锂电池的技术特点,然后以功率范围120～1200 kW,储能范围1～10 MWh的船用燃料电池和锂电池系统为对象,对比分析其重量、体积和价格,最后针对大功率、高储能的船型提出燃料电池和锂电池混合的动力方案.     

Incorporating refuelling behaviour and drivers’ preferences in the design of alternative fuels infrastructure in a city

The purpose of this article is to present an optimization model to plan the deployment strategy for hydrogen refuelling stations in a city when Origin–Destination (OD) data are not available. This model considers two objectives: to maximize the traffic covered by the selected hydrogen refuelling stations and minimize the average distance of the city’s inhabitants to the nearest hydrogen refuelling station. As OD data are assumed to be unavailable, the clustering of stations in the highest traffic zones is prevented by a new constraint that takes into account information on the distribution of existing conventional refuelling stations. This model is applied to Seville, a city in Southern Spain of about 140 km² with a population of around 700,000. This application uses the results of a survey of more than 200 Sevillian drivers on their current refuelling tendencies, their willingness to use alternative fuel vehicles and their minimum requirements (regarding maximum distance to be travelled to refuel and number of stations in the city) when establishing a network of alternative refuelling stations.     

雌激素对肝纤维化大鼠肝星状细胞活化及胶原合成的影响

目的　通过雌激素对CCl4诱导的肝纤维化大鼠肝星状细胞活化及胶原合成影响的研究 ,探讨雌激素对肝纤维化的抑制作用。方法　CCl4诱导大鼠肝纤维化动物模型 ,观察雌激素 (苯甲酸雌二醇 1mg·kg-1)对大鼠肝纤维化形成过程中肝星状细胞的α 平滑肌肌动蛋白表达和对肝脏胶原含量的影响 ,并分别检测血清学标志及肝脏组织学等变化。结果　与肝纤维化模型组相比 ,雌激素可以明显降低大鼠血清ALT、AST水平 ,减少透明质酸和Ⅳ型胶原等纤维化指标的升高程度 (P均 <0 .0 5 ) ,抑制肝星状细胞对α 平滑肌肌动蛋白的表达和肝脏胶原沉积 ,减少肝脏I型胶原的合成。结论　雌激素可明显抑制肝纤维化大鼠肝星状细胞的活化及胶原合成 ,发挥对肝纤维化的抑制作用     

平推式造波板运动的数值模拟

平推式推板造波机是近岸及海洋工程波浪物理模型试验中非常重要的试验设备.文章通过垂向二维数学模型,利用线性造波理论来模拟造波板运动,分析了造波板前后水体动力过程,以及当造波板后不设消波设施时,造波板至后墙距离对水体动力过程的影响.该数学模型以包含水气二相流系统的Navier-Stokes方程为基本控制方程,应用粒子Lev...     

基于TTCAN的燃料电池系统分布式控制系统设计

以32位单片机MC68376及8位单片机C8051F040为核心芯片设计了基于TTCAN的燃料电池系统分布式控制系统。该设计在硬件上高度切合燃料电池系统的特点;在软件上以嵌入式实时操作系统为平台;在通信网络上采用TTCAN的概念对传统CAN网络进行有序化;在控制策略上采用负载跟随的算法。台架试验表明,该分布式控制系统具有较好的软硬件稳定性和可靠性。