醛固酮及螺内酯对肝星状细胞中TIMP-1和MMP-2mRNA表达的影响

目的观察醛固酮及螺内酯对活化的肝星状细胞(HSC-T6)作用后不同时间段MMP-2和TI MP-1 mRNA的表达情况。方法采用RT-PCR的方法测定HSC-T6中MMP-2、TI MP-1 mRNA的表达。结果活化的HSC可表达MMP-2及TI MP-1的mRNA。醛固酮组MMP-2、TI MP-1的mRNA在48、72 h表达均高于对照组,在作用24、48、72 h时MMP-2、TI MP-1的mRNA的表达随时间递增。而螺内酯组则相反。醛固酮加螺内酯组与单加醛固酮组相比MMP-2、TI MP-1的mRNA表达下降。结论醛固酮可能通过促使MMP-2及TI MP-1 mRNA的表达促纤维化,螺内酯可抑制这一作用。     

原发性支气管肺癌中PTEN基因的蛋白表达及意义

目的研究抑癌基因PTEN在原发性肺癌中的蛋白表达及其临床意义。方法应用免疫组织化学SP法检测56例手术切除的肺癌石蜡标本及3例正常肺组织中的PTEN基因的蛋白表达情况。结果①正常肺组织中PTEN蛋白表达的阳性率明显高于肺癌患者,而在小细胞肺癌中的阳性表达低于非小细胞肺癌;②在56例肺癌患者中,随着分化程度的降低,PTEN的蛋白阳性表达率也随之下降;③Ⅰ、Ⅱ期肺癌患者的PTEN蛋白阳性表达率高于Ⅲ、Ⅳ期患者;④在19例有转移的肺癌患者中,PTEN表达阳性率明显低于无转移的患者。结论PTEN基因的表达与肺癌的病理类型、组织的分化程度、临床分期以及有无淋巴结转移密切相关。     

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根据时变的OD预测信息,基于分层递阶的思想,建立了一个新颖的高速公路优化控制系统。控制结构分为三层：网络负荷分配层对长时期内总的交通需求进行预测,提前确定将来排队长度的上界;全局最优控制层预测未来的交通状态,为路网中的各个匝道建立协调约束;局部反馈控制层根据实测的交通条件及全局最优控制层的寻优结果决定匝道调节率。仿真结果表明,控制系统具有良好的动态性能,协调了各个匝道之间的利益,实现了高速路网整体性能的优化。     

9 000 hp拖船总振动的计算与试验研究

简要介绍了9000hp拖船总体振动的计算方法,并采用锚激发对船体的总振动进行试验研究。试验结果表明利用迁移矩阵法计算得到的压载出港条件下全船的振动结果与试验结果差距不大。     

Essential elements in tactical planning models for container liner shipping

Tactical planning models for liner shipping problems such as network design and fleet deployment usually minimize the total cost or maximize the total profit subject to constraints including ship availability, service frequency, ship capacity, and transshipment. Most models in the literature do not consider slot-purchasing, multi-type containers, empty container repositioning, or ship repositioning, and they formulate the numbers of containers to transport as continuous variables. This paper develops a mixed-integer linear programming model that captures all these elements. It further examines from the theoretical point of view the additional computational burden introduced by incorporating these elements in the planning model. Extensive numerical experiments are conducted to evaluate the effects of the elements on tactical planning decisions. Results demonstrate that slot-purchasing and empty container repositioning have the largest impact on tactical planning decisions and relaxing the numbers of containers as continuous variables has little impact on the decisions.     

复合式康复机械手设计

为满足手臂运动功能障碍患者的康复需要,设计了一种复合式康复机械手.介绍了它的机械结构、工作原理和三种控制方式及根据D-H方法得出的康复机械手位姿的齐次变换矩阵.该康复机械手既可单独实现小臂、手掌的曲张运动又可实现小臂、手掌的联动；通过样机试验,验证了该康复机械手的基本功能,可为手臂运动功能障碍患者提供有效的康复训练.     

消失模液锻中气隙压力和气流速度的计算分析

通过计算分析了消失模液锻制备颗粒增强金属基复合材料中，附带的增强颗粒泡沫载体与金属液作用后产生的气隙压力和气流速度，然后在消失模液锻TiC／ZG270-500实验中测量气隙压力和气流速度值，并探讨液锻工艺参数对气隙压力和气流速度的影响规律．实验结果表明：气隙压力和气流速度随充型速度、浇注温度、内浇口与排气孔横截面积比呈递增趋势，但均不随成形压力变化．此外，气流速度还随排气孔与型腔横截面积比增大而增大，气流速度随工艺参数变化趋势较平缓．     

矩阵变换器技术及其应用研究

阐述了多年来对矩阵变换器技术及其应用进行研究的认识和体会,总结了在矩阵变换器调制技术、矩阵变换器系统优化设计、矩阵变换器系统建模和控制设计等方面的研究成果,10kW双级矩阵变换器系统反复试验和测试的结果表明,双级矩阵变换器的工业应用指日可待。     

Local joint flexibility element for offshore plateforms structures

A large number of offshore platforms of various types have been installed in deep or shallow waters throughout the world. These structures are mainly made of tubular members which are interconnected by using tubular joints. In tubular frames, joints may exhibit considerable flexibility in both elastic and plastic range of response. The resulting flexibility may have marked effects on the overall behavior of offshore platforms.This paper investigates the effects of joint flexibility on local and global behavior of tubular framed structures in linear range of response. A new joint flexibility element is developed on the basis of flexibility matrix and implemented in a finite-element program to account for local joint flexibility effects in analytical models of tubular framed structures. The element formulation is considerably easy and straightforward in comparison with other existing tubular joint elements. It was concluded that developed flexible joint model produces accurate results comparing to sophisticated multi-axial finite element joint models.     

基于出行规律的高峰小时客流OD矩阵快速估算方法

为了快速准确地计算城市交通高峰小时客流OD矩阵,提出一种简单易行的推算方法。该方法近似认为城市出行均为由家出行,从而将交通产生-吸引矩阵分解为一个由家出发的OD矩阵和一个返回家里的OD矩阵,通过调查交通高峰小时系数,将由家出发的OD矩阵与返回家里的OD矩阵按一定比例进行叠加即得到高峰小时客流OD矩阵,并应用该方法进行了算例分析。结果表明:该方法简单易行,抓住了出行的主要规律,可省去大规模的调查,具有一定的科学性与准确性,在潍坊市滨海交通客流规模预测研究中得到了较好的应用。