线粒体细胞色素c介导的caspase-9激活通路参与大骨节病关节软骨细胞凋亡的发生机制

目的通过评价线粒体功能研究线粒体介导的caspase-9激活通路参与成人大骨节病关节软骨细胞凋亡的机制。方法关节软骨细胞培养,Hoechst 33258染色检测软骨细胞核形态,流式细胞仪检测软骨细胞凋亡率和细胞内活性氧含量,Western bloting检测细胞色素c的表达,荧光法检测caspase-9和caspase-3活性。结果大骨节病患者关节软骨细胞较正常软骨细胞凋亡百分率增加,线粒体细胞色素c释放,caspase-9和caspase-3活性增高,且活性氧含量增加。结论线粒体氧化应激参与了大骨节病软骨细胞的病理生理变化,线粒体功能障碍可能在大骨节病关节软骨细胞凋亡过程发挥了重要作用。     

IMO对生物污损议题的关注

生物污损造成的环境生态破坏问题是近些年来海洋环境保护工作者研究的一个热点问题。船舶的生物污损带来的外来物种入侵问题也引起了IMO的高度关注，该问题在2008年召开的散装液体和气体分委会（BLG）第12次会议上成为正式议题。文中简要介绍了船舶生物污损的危害，结合国外一些国家对生物污损问题的管理经验，与压栽水公约的立法过程进行对比，针对IMO可能采取的立法措施进行了分析，对我国航运业应采取的应对措施提出了意见和建议。     

基于系统可靠性的机电器材随舰携带研究

通过研究舰船机电器材航行期间维修保障的特点,着重分析随舰携带备件品种和数目的影响因素,从满足动力装置系统可靠性的角度出发,综合考虑经费、装载重量和装载空间等约束条件,建立备件携带量的数学模型,并给出一般模型的求解方法,最后给出应用实例。     

Sea ice and the onshore–offshore gradient in pre-winter zooplankton assemblages in southeastern Beaufort Sea

Zooplankton communities were studied in southeastern Beaufort Sea (Arctic Ocean) in September–October 2002. Cluster analysis and non-metric multidimensional scaling revealed three distinct mesozooplankton assemblages. A neritic assemblage occurred on the Mackenzie Shelf and in Franklin Bay, while distinct off-shelf assemblages prevailed in the Cape Bathurst Polynya and on the Beaufort Slope respectively. Over 95% of the mesozooplankton was comprised of eight copepod taxa. Pseudocalanus spp. contributed predominantly to the discrimination of the three assemblages and was the only significant indicator of the Shelf assemblage. Oithona similis, Oncaea borealis, Metridia longa and Calanus hyperboreus were indicators of the Polynya assemblage. Cyclopina sp. and Microcalanus pygmaeus were indicative of the overall off-shelf community (Polynya and Slope assemblages). The importance of omnivores and carnivores increased from the shelf to the polynya and the slope. Station depth and duration of reduced ice conditions during summer (< 50% ice concentration) underpinned the distribution of the assemblages (r² = 0.71 and 0.45 respectively). The abundance of Pseudocalanus spp. was independent of depth and increased with the duration of reduced ice conditions (r_s = 0.438). The abundance of Cyclopina sp., M. pygmaeus and other indicators of the offshore assemblages followed the opposite trend (r_s = − 0.467 and − 0.5 respectively). Under continued climate warming, a reduction of the ice cover will affect the biogeography of mesozooplankton on and around the Mackenzie Shelf, to the potential advantage of Pseudocalanus spp. and other calanoid herbivores.     

主冷却剂泵变频调速方案可行性研究

从提高核动力装置安全性的角度出发，通过对变频调速技术及两种方案的对比计算研究，从理论上论证了主冷却剂泵采取变频调速方案的优点和可行性.     

LB-30型沥青混凝土拌和设备给料装置的改造

针对笔者单位LB-30沥青混凝土拌和设备给料装置不能很好保证漏料量,级配精度不高等问题提出了给料斗分别加装给料装置小型皮带机的方案,使问题得到了较好的解决.     

四冲程船用柴油机的建模和实时仿真

根据准稳态的概念，在充分多的试验数据的基础上，结合工作原理建立了适用于实时仿真的四冲程船用柴油机推进装置的多阶非线性动态模型。这种模型能反映柴油机内部各参数，精度较高，计算工作量适中。     

微机网络型全自动电站监控系统的结构及其控制原理

本文介绍一种舰船用微机网络型全自动电站监控系统的自动控制原理及方法,该系统实现了不同种类电源供电自动联锁;船电和岸电不断电自动切换;有故障机组或过载时,备用机组自动投入和报警;轻载时,备用机组自动停机;同时还可在配电控制室遥控机组自动起动投入或自动解列停机;另外,还实现了各机组热工参数越限声光报警及大负荷设备起动询问联锁功能;最后,依据系统的结构特点,说明系统是如何采取措施提高其可靠性。     

一种新式联合动力装置在现代战斗舰艇上的应用分析

首先简要回顾了当今世界上比较流行的MEKO舰船设计方法,介绍了新型联合动力装置CODAG WARP的由来及背景。在介绍南非海军轻型隐身护卫舰MEKO A-200 SAN基本情况后,详细分析了CODAG WARP动力装置的特点,并进行了小结。     

Design of a forced control system for a dynamic road simulator using QFT

This paper presents the road simulator control technology for reproducing a road input signal to implement real road data. The simulator consists of a hydraulic pump, a servo valve, a hydraulic actuator and its control equipment. QFT (Quantitative Control Theory) is utilized to control the simulator effectively. The control system illustrates a tracking performance of the closed-loop controller with a low order transfer function G(s) and a pre-filter F(s) for a parametric uncertainty model. A force controller is designed to communicate the control signal between the simulator and digital controller. Tracking specification is satisfied with upper and lower bound tolerances on the steep response of the system to the reference signal. The efficacy of the QFT force controller is verified through the numerical simulation in which combined dynamics and actuation of the hydraulic servo system are tested. The simulation results show that the proposed control technique works well under an uncertain hydraulic plant system. The conventional software (Labview) is used to make up for the real controller on a real-time basis, and the experimental works show that the proposed algorithm works well for a single road simulator.