Optimal New Business for Insurer to Minimize the Ruin Probability under Interest Force

Introduction In ruin theory, minimizing the ruin probability ofan insurance company is of practical importance. Bystochastic control theory, a great deal of work hasbeen done on the problem with different control varia-bles. Browne[1]considered a risk mod…     

A NORTHWEST DATABASE MODEL OF SHORT TANDEM REPEAT LOCI IN FORENSIC MEDICINE

CriminalratewasrisingyearafteryearinthenorthwestChina .Itisnecessarytoestablishthefo rensicDNAdatabase .Thereweremanyshorttan demrepeats (STRs)thatappearedtobeabundantandoccurred 15 - 2 0kbonaverageinthehumange nome .STRlociconsistedof 2 - 6bpinlengthasitscoresequences[1] .Thecharacteristicsofhighlyeffi cientandmultipleamplificationmadeSTRsuperiortothetraditionalgeneticmarkers .Alloftheselect edSTRlocihadcommonalleleslessthan 35 0bpinsize[2 ] .STRwasthemostidealgeneticmarkerbe causeofi…     

PCR-SSP检测人胰腺癌细胞株PC-2K-ras基因点突变及其方式

目的　检测人胰腺癌细胞株PC 2K ras基因点突变及其突变方式 ,明确基因治疗靶点的碱基序列。方法　针对K ras基因第 1 2位密码子点突变方式 (CGT、CAT、GTT)设计顺序特异性引物 (SSP) ,对人胰腺癌细胞株PC 2进行聚合酶链反应 (PCR) ,扩增产物借助聚丙烯酰胺凝胶电泳判定该细胞株有无K ras基因点突变及其突变方式。结果　人胰腺癌细胞株PC 2存在K ras基因点突变 ,突变方式为CGT。结论　PCR SSP法简便快速 ,特异性高 ,本研究结果为胰腺癌的下一步基因治疗奠定了基础     

轮对摇头运动对轮轨滚动接触蠕滑率／力的影响

用数值分析方法分析了单轮对的摇头运动对其左右轮轨滚动接触斑上蠕滑率／力的影响。在轮轨滚动接触蠕滑率／力关系分析方面，利用了Ｋａｌｋｅｒ的三维弹性体非赫兹滚动接触计算模型。通过分析计算可知，轮对摇头角运动参量是影响轮轮之间横向蠕滑力的主要因素。     

干气密封端面流场的数值模拟

为深入了解干气密封的端面流场特性,提高其运行稳定性,基于Navier-Stokes方程、层流模型和SIMPLEC算法,对干气密封端面流场进行了数值模拟,考察了不同端面间隙和转速情况下端面气膜压力分布和开启力情况.数值模拟结果表明,端面气膜压力总是在槽坝交界处产生较大变化,在气体流出的槽坝交界处产生流体动压,在气体流入的槽坝交界处局部存在负压;流体动压效应随端面间隙增大迅速减弱,在间隙较小(约小于3μm)时动压效应显著;进出口压力差的存在将提高密封端面的气膜开启力和刚度;增大正压区域的同时减小负压区域,可提高端面开启力和气膜刚度,从而提高密封的稳定性.     

柱式桥墩盖梁内力计算方法探讨

笔者阐述了两种不同计算图式下盖梁内力计算方法,并进行了对比分析.分析表明,当考虑立柱刚度影响时,盖梁内力将进行二次分配,致使跨中正弯矩减小、支点负弯矩增大(称之为“刚架效应”),随着立柱与盖梁的线刚度比的增大,此种效应越显著.当立柱与盖梁的线刚度比较小时,可采用简化的双悬臂简支梁(连续梁)图式,但在支点截面应作适当的加强处理;而对于重要桥梁或立柱与盖梁的线刚度比较大的桥梁,宜采用双悬臂刚架结构图式进行计算.     

DETECTION AND SIGNIFICANCE OF HBV IN RENAL TISSUE OF HBV ASSOCIATED GLOMERULONEPHRITIS PATIENTS

ＳｉｎｃｅＣｏｍｂｅｓ[1] ｆｉｒｓｔｌｙｒｅｐｏｒｔｅｄｏｎｅｃａｓｅｏｆｔｈｅＨＢＶ ａｓｓｏｃｉａｔｅｄｍｅｍｂｒａｎｏｕｓｎｅｐｈｒｏｐａｔｈｙ (ＨＢＶ ｍＧＮ )ｉｎ 1971,ｔｈｅｒｏｌｅｏｆｈｅｐａｔｉｔｉｓＢｖｉｒｕｓ (ＨＢＶ)ｐｌａｙｅｄｉｎ ｇｌｏｍｅｒｕｌｏｎｅｐｈｒｉｔｉｓｗａｓ ｇｅｎｅｒａｌｌｙ ｐａｉｄｃｌｏｓｅａｔｔｅｎｔｉｏｎｗｈｅｎｉｔｓｍｅｃｈａｎｉｓｍｗａｓｉｎｖｅｓｔｉｇａｔ ｅｄ .Ｉｔｒｅｍａｉｎｓｕｎｃｅｒｔａｉｎａｔｐｒｅｓｅｎｔ,ｈｏｗｅｖｅｒ ,ｈｏｗＨＢＶｐｌ…     

ARTIFICIAL IMMUNE ALGORITHM OF MULTICELLULAR GROUP AND ITS CONVERGENCE

Objective To find out more extrema simultaneously including global optimum and multiple local optima existed in multi-modal functions. Methods Germinal center is the generator and selector of high-affinity B cells, a multicellular group＇s artificial immune algorithm was proposed based on the germinal center reaction mechanism of natural immune systems. Main steps of the algorithm were given, including hyper-mutation, selection, memory, similarity suppression and recruitment of B cells and the convergence of it was proved. Results The algorithm has been tested to optimize various multi-modal functions, and the simulation results show that the artificial immune algorithm proposed here can find multiple extremum of these functions with lower computational cost. Conclusion The algorithm is valid and can converge on the satisfactory solution set D with probability 1 and approach to global solution and many local optimal solutions existed.     

中国新疆哈萨克族人群CSF1PO、TH01和TPOX三个STR位点的遗传多态性

目的　获得CSF1P0、TPOX和TH0 1三个短串联重复序列 (shorttandemrepeat ,STR)在新疆哈萨克族人群中等位基因频率、基因型频率及相关法医学数据。方法　应用PCR技术、4 0 g·L-1(4% )变性聚丙烯酰胺凝胶电泳及银染技术对上述三个STR位点分型。结果　新疆哈萨克族人群CSF1P0位点有 8个等位片段 ,TPOX位点有 8个等位片段 ,TH0 1位点有 7个等位片段 ;3个位点的基因型分布均符合Hardy Weinberg平衡 ;各位点杂合度分别为 0 .875 3、0 .8777、0 .932 1,多态信息量分别为 0 .74 0 1、0 .75 6 8、0 .75 0 9。结论　得到的上述三个位点的基因频率数据可为新疆哈萨克人群遗传学研究和法医学应用提供依据     

隧道工程监理工作重点

新奥法的主导思想，是把隧道的围岩和初期支护结构一起组成一个完整的受力体糸，承受压力。这种受力体系，主要是通过锚杆把坑道周围的岩体（简称围岩）拉住，与初期支护一起受力。根据新奥法的原理，浅谈我们在日常的监理检查工作中，应该抓住的几个要点。