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Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM. 相似文献
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目的探讨2型糖尿病(T2DM)患者糖耐量正常的一级亲属胰岛β细胞功能及胰岛素抵抗情况,并分析胰岛素抵抗的相关因素。方法选取T2DM患者糖耐量正常的一级亲属63例,根据胰岛素抵抗指数分为胰岛素抵抗组及非抵抗组;选取30例健康体检者作为正常对照组。对所选的93例对象进行血压、血糖、胰岛素、血脂的测定,并计算稳态模型胰岛素抵抗指数(HOMA-IR)及胰岛β细胞功能指数(HOMA-β)。结果①糖尿病患者一级亲属组与对照组相比,胰岛素水平、HOMA-IR、HOMA-β明显升高(P<0.05);②胰岛素抵抗组体质指数、舒张压、甘油三酯、餐后血糖、HOMA-β明显高于胰岛素非抵抗组(P<0.05);③相关分析示胰岛素抵抗与体质指数、舒张压、甘油三酯、餐后胰岛素呈正相关(P<0.01,P<0.05),与空腹血糖、餐后血糖、空腹胰岛素、收缩压、胆固醇无显著相关性(P>0.05)。结论T2DM患者一级亲属存在胰岛β细胞代偿性的高分泌,早期已经出现胰岛素敏感性的下降和胰岛素抵抗。胰岛素抵抗与体重增加、舒张压升高及甘油三酯的升高有关。提示对糖尿病患者一级亲属应严格控制体重、血压及血脂,对减少T2DM具有积极意义。 相似文献
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指出了目前对高桩码头维护、检测的必要性和迫切性 ,并对码头结构的破损类型、检测的内容及方法、评估的途径进行了较详细的探讨 ,同时还提出了检测周期的建议。 相似文献
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In India pedestrians usually cross the road at mid-block crosswalks due to ease of access to their destination or the development of adjacent land use types such as shopping, business areas, school and residential areas. The behaviour of pedestrian will change with respect to different land use type and this change in behaviour of pedestrian further reflects change in perceived level of service (LOS). So, it is important to evaluate the quality of service of such crossing facilities with respect to different land-use type under mixed traffic conditions. In this framework, pedestrian perceived LOS were collected with respect to different land-use type such as shopping, residential and business areas. The ordered probit (OP) model was developed by using NLOGIT software package, with number of vehicles encountered, road crossing difficulty as well as safety considered as primary factors along with pedestrian individual factors (gender and age), land-use type and roadway geometry. From the model results, it has been concluded that perceived safety, crossing difficulty, land-use condition, number of vehicles encountered, median width and number of lanes have significant effect on pedestrian perceived LOS at unprotected (un-signalized) mid-block crosswalks in mixed traffic scenario. The inferences of these results highlights the importance of land use planning in designing a new set of pedestrian access facilities for unprotected mid-block crosswalks under mixed traffic conditions. Also the study results would be useful for evaluating pedestrian accessibility taking into account different land-use type and planning required degree of segregation with vehicular movement at unprotected mid-block crosswalk locations. 相似文献