浅议高职语文教学所面临的问题及其对策

高职院校培养的是适应当前及未来社会发展需求的高素质应用性专门人才,客观上要求毕业生应具备较好的汉语阅读、口语、书面语和汉字书写等语文基本技能。但由于种种原因,目前高职院校在培养和提高学生这些素质方面存在不少问题,文章对此作了分析,并提出相应的对策。     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

健胃愈疡颗粒对慢性胃炎伴幽门螺杆菌感染胃黏膜PAF、PS2的表达及对上皮细胞凋亡的影响

目的观察健胃愈疡颗粒(JWYY)对幽门螺杆菌相关性胃炎胃黏膜乳癌相关肽(PS2)和血小板活化因子(plate-let activating factor,PAF)表达的变化,并分析其可能的作用机制。方法80例幽门螺杆菌感染慢性胃炎患者随机分为2组,治疗组42例给予健胃愈疡颗粒治疗,对照组38例给予西药三联药物治疗。应用胃镜下活检胃黏膜组织快速尿素酶和Warthin-Starry染色法检测幽门螺杆菌,应用Western blot检测PS2、PAF表达变化。应用末端转移酶介导的dUTP切口末段标记法(TUNEL)检测细胞凋亡。第4周复查胃镜。结果治疗组凋亡指数明显比对照组减少(P<0.05),治疗组总有效率高于对照组(P<0.05)。Western blot检测显示:JWYY颗粒可上调PS2并下调PAF的表达,而对照组对胃黏膜PS2和PAF的表达影响不大。结论健胃愈疡颗粒治疗幽门螺杆菌(Hp)相关性胃炎可能与杀灭Hp、上调PS2和下调PAF的表达来抑制细胞凋亡有关。     

“船舶—堆场—列车”混堆堆场箱位分配模型

集装箱海铁联运港口堆场作业箱型复杂,为了提高港口作业能力和效率,基于进口、出口箱的混合堆存方式,对"船舶-堆场-列车"作业堆场箱位分配问题进行研究."船舶-堆场-列车"作业堆场负责堆存通过船舶、列车及外集卡进出港口的集装箱.本文在待分配箱的作业时间及箱区已知的前提下,以集装箱堆存产生的压箱数最小为目标,建立"船舶-堆场-列车"作业混堆堆场箱位分配模型,根据模型特点设计了启发式算法进行求解,并进行算例分析.结果表明,所建模型和求解算法能够有效减少堆场的压箱数,满足箱型堆存要求,提高港口作业效率.     

EGFR、Ku70、NF-κB及Bcl-2在Graves病中的表达及意义

目的研究Graves病患者细针穿刺组织中EGFR、Ku70、NF-κB和Bcl-2基因的表达水平,探讨其在Graves病发生发展中的作用。方法 Graves病组患者59例,平均年龄(44.66+12.94)岁,其中男16例,女43例;甲状腺结节周围正常甲状腺组织标本27例为对照组,平均年龄(44.64+14.27)岁,其中男6例,女21例。采用实时荧光定量逆转录-多聚酶链反应(RT-PCR)法检测EGFR、Ku70、NF-κB和Bcl-2在Graves病及对照组甲状腺组织中的表达,t检验分析基因表达水平差异;Pearson相关法分析基因表达与临床特征及相关血清学指标之间的关系。结果上述基因在对照组及Graves病甲状腺组织中都有不同程度的表达。Graves病患者组织中EGFR及Ku70的表达水平明显高于对照组甲状腺组织(1.752±0.660 vs.0.859±0.125,P<0.05;3.304±0.402 vs.0.768±0.102,P<0.001);NF-κB及Bcl-2的表达水平明显低于对照组甲状腺组织(0.578±0.066 vs.0.884±0.085,P<0.001;0.834±0.086vs.1.235±0.261,P<0.05)。Graves病组织中NF-κB与Bcl-2表达水平呈正相关(r=0.399,P<0.001)。Graves病组织中Ku70的表达水平与血清TgAb水平呈正相关(r=0.263,P<0.05),而其他基因表达与相关血清学指标无关(P均>0.05)。结论 Ku70、EGFR、NF-κB、Bcl-2介导的信号转导通路可能参与了Graves病的发生、发展过程。     

船用低速柴油机曲轴轴向振动研究

以船用大功率低速柴油机柔性体曲轴为对象,在考虑气体力、运动部件惯性力、扭纵耦合效应等因素的情况下,建立曲轴、连杆、活塞的刚柔混合动力学模型。通过数值仿真,分别对连杆推力、连杆法向力和切向力对曲轴轴向振动的影响进行分析。分析结果表明：法向力是曲轴轴向振动的直接激励源,切向力是曲轴轴向振动的间接激励源-切向力引起曲轴扭振,进而引起曲轴纵振;同时法向力和切向力对曲轴轴向振动的影响非常相近;而连杆推力(法向力和切向力合力)引起的曲轴轴向振动是扭纵耦合振动的结果,并非两种分力作用结果的简单叠加。     

基于产业转移的中国汽车产业战略研究

通过对世界汽车产业四次转移的阐述,分析了世界汽车产业转移的原因与特点,认为我国面临着承接世界汽车产业第四次转移的历史性机遇,提出我国汽车产业发展的战略目标：利用20年左右时间,把我国建设成为继美、欧、日之后的第四个世界汽车产业中心。     

浅谈新时代我国高校德育工作

21世纪是一个高科技飞速发展的社会,一个竞争激烈的社会。毫无疑问,在新的时代里所显示出新的发展特点,必然向大学生们提出了更高的素质要求。要搞好高校的德育工作必须充分认清形势,面对各种困难,要实事求是,大胆进行方法和方式的改革,不断更新我们的教育理念。     

土体固结剂(HEC)在军事工程中的应用探讨

根据高强高耐水土体固结剂(HEC)的性能和特点,结合现代军事工程的要求,分析了HEC在军用道路工程、野战防护工程以及海岸港口等军事工程的应用可行性,探讨了如何在军事工程中的应用问题。     

A two-phase model for dry port location with an application to the port of Dalian in China

This paper provides guidance for an optimal and reasonable dry port layout for the port of Dalian in China. We present a two-phase framework on the location of dry ports, which solves the selection of candidate inland cities and optimal dry port location choice, respectively. Fuzzy C-Means Clustering is applied to select alternative cities in the vast hinterland of the seaport of Dalian, with a view to identify evaluation factors that affect the location selection decision. A cost-minimisation linear programming solution is proposed, with the aid of a genetic algorithm, to choose the optimal location as well as capacity level among the candidate inland cities.