用RP-HPLC法分析地尔硫在兔体内的药动学及组织分布

以尼群地平为内标，用反相高效液相色谱法（ＲＰ－ＨＰＬＣ）测定兔口服地尔硫后血浆和组织器官的药物浓度。药动学符合二房室模型。主要参数∶Ｔ１／２（α）＝０．５１ｈ，Ｔ１／２（β）＝６．１１ｈ，Ｔ１／２（ｋａ）＝０．２５ｈ，Ｔ（ｐ）＝０．５２ｈ，口服２ｈ后在胆汁、血、脾、心、肾、肝、大脑和小脑药物浓度分别为∶０．５５９ｍｇ／Ｌ、０．３７５ｍｇ／Ｌ、４．５６２μｇ／ｇ、０．７７１μｇ／ｇ、１．０９３μｇ／ｇ、１．４３９μｇ／ｇ、０．３５９μｇ／ｇ和０．７４１μｇ／ｇ。     

Habitat characteristics as determinant of the structure and spatial distribution of epibenthic and demersal communities of Le Danois Bank (Cantabrian Sea, N. Spain)

The purpose of this paper is to detect and describe general trends in the spatial distribution of epibenthic and demersal communities of Le Danois Bank (El Cachucho) in relation to the environmental variables that characterize their habitat by means of multivariate ordination. Data were derived from two multidisciplinary surveys carried out in October 2003 and April 2004 included in the ECOMARG project. The surveys were focused on the study of the physical scenario, including both geological (seabed characterization from bathymetry and backscatter data) and hydrographic features, and the different compartments of the benthic fauna (endobenthic, epibenthic, suprabenthic and demersal communities). For the present study, epibenthos and demersal species were sampled using two different gears, a 3.5 m beam trawl and a Porcupine 39/52 type baca otter trawl respectively. The total species richness combining both samplers ascended to 221, including 71 species of fishes, 65 crustaceans, 35 molluscs, 29 echinoderms, 10 cnidarians and 5 sponges.Multivariate methods were used for the study of the characteristics of communities and habitats. Hierarchical cluster analysis was applied to calculate and visualize similarities between samples in terms of species composition. To assess the amount of variation of faunal densities related to a set of eight environmental variables, a redundancy analysis (RDA) was used. The set of environmental variables used were: depth, near-bottom temperature and salinity, sedimentary typology (dry weight percentages of coarse sands, medium and fine sands, silt and organic matter) and seafloor reflectivity. Using the spatial distribution of the ranges of depth and seafloor reflectivity that characterize the habitats of the faunal assemblages we defined the spatial distribution of the different communities.The multivariate analysis of 18 beam-trawl samples and 15 otter trawl samples showed the existence of 4 main assemblages associated with the more characteristic habitats of the area. The Callogorgia–Chimaera community live mainly in the areas at the top of the Bank (425–550 m depth), where the sediment coverage is lower and there exists a high presence of rocky outcrops. The Gryphus–Galeus community were found in the areas at the top of the Bank covered by medium and fine sand sediments with low organic matter content. The Phormosoma–Trachyrincus community live on the sedimentary terraces that characterize the Bank break (550–800 m) and the Pheronema–Deania community occupy all the deeper (800–1050 m) sedimentary grounds of the inner basin.     

巴黎市域轨道交通线路及车站布置特点分析

分析了巴黎市域轨道交通(RER)线的发展建设过程和线路特点,并重点研究了市域轨道交通线的几种主要车站布置形式。折返站布置能适应一端折返,且能满足列车越行的需要;终点站的折返能力和存车能力加强;换乘站合理设置侧线、渡线和相应的连络线;分岔站的布置应尽量避免主线和支线间的行车干扰,方便乘客换乘。这些市域轨道交通线线路、车站设置的特点对我国市域轨道交通线的规划、建设具有借鉴作用。     

Recent sedimentary study of the shelf of the Basque country

The Northern Iberian margin of the Spanish Basque country (provinces of Gipuzkoa and Viscaia) is characterized by a narrow continental platform, which receives inputs of riverine particulate matter from the numerous riverine systems located within the Basque country. This particulate matter is subsequently deposited within the Bay of Biscay, and Gouf de Capbreton [Frouin, R., Fiuza, A.F.G., Ambar, I., Boyd, T.J., 1990. Observations of a poleward surface current off the coasts of Portugal and Spain during winter. Journal of Geophysical Research 95 (C1), 679–691]. The main goal of this study is to establish a map of the surface sediment distribution of the Basque continental shelf and more specifically to map the muddy patch located at the eastern side of that continental shelf.Three oceanographic cruises were conducted in 2003 and 2004. From these campaigns 340 surface samples, 12 short cores and 3 gravity cores have been collected over the mid and outer shelf from depths ranging between 50 m and 150 m deep. 3 seismic profiles were obtained across the shelf mud patch using a Sparker device.Sediment grain-size analyses were performed by the classical physical method of sieving and use of settling columns. The POC (Particular Organic Carbon) amounts in sediment and water samples were determined using the Strickland and Parsons' method [Strickland, J.D.H., Parsons, T.R., 1972. Determination of particulate carbon. In : A practical handbook of seawater analysis. Fisheries ResearchBoard of Canada, Ottawa, pp. 207−211] as adapted by Etcheber [Etcheber, H., 1981. Comparaison des diverses méthodes d'évaluation des teneurs en matières en suspension et en carbone organique particulaire des eaux marines du plateau continental aquitain. Journal de Recherche Océanographique VI (2), 37−42]. Radioisotopic measurements (²¹⁰Pb_exc) were made using a semi-planar germanium detector coupled to a multichannel analyser. Radiographical analysis was performed with an X-ray equipment (SCOPIX®) coupled with a radioscopy instrumentation and processing unit.Firstly, a detailed sedimentological map of this shelf has been produced and secondly, geophysical surveys have precisely mapped the geometry of the main mud patch on the continental shelf. In the mud patch itself the rates of sedimentation are between 0.13 and 0.50 cm yr^− 1. The maximum rate of sedimentation is located in the central mud patch, whereas the minimum rate of deposition occurs close to the rocky outcrops. These results seem to be in agreement with the estimation of the total thickness of the mud patch revealed by seismic profiles. The central part corresponds to the maximum thickness of 7 m.Interpretations of the associated oceanic current forcing factors (current direction, wave fetch and wind directional modes) relating to the identified sediment depositional zones are also undertaken.     

HX_D3型机车用DC110V电源装置

HXD3型机车用日本原装RFE081-A0型DC 110 V电源装置采用DC/DC变换形式,微机控制系统,功率元件为IGBT,整个装置包含两个独立的单元,互为备用,电源输入也采用了冗余设计,保证运行的稳定性和可靠性,文章对其工作原理进行了剖析。     

铁路10kV配电所改造设计若干问题探讨

铁路配电所是铁路电力供电系统的主要组成部分,既有配电所改造设计与新建配电所设计有着明显的不同,需要满足技术先进性、设备可靠性以及经济性,而且还要解决现有设备在运行过程中的问题.本文对铁路10 kV配电所改造设计中遇到的问题进行分析与讨论,并提出设计应采用的策略.     

不同方法对南黄海重现波高计算值的影响

采用SWAN波浪模型对江苏南黄海地区1979~2018年共40 a的波况进行模拟及验证,将模拟结果与实测资料进行比对,吻合良好。百年重现波高分布通过基于年极值和月极值的广义极值分布函数(GEV)和超阈值取值方法(POT)的广义帕累托分布模型(GP)计算得出。计算结果表明,不同方法的计算结果在辐射沙洲北部地区差别最大,采用月极值所得重现波高偏小,采用年极值计算的重现波高在辐射沙洲南北外围地区最大,其余地区则以POT方法为大值。在分别采用不同数据长度计算重现波高的试验中得出,取月极值的GEV分布计算结果对时间跨度的改变不敏感,而取年极值受之影响最大,POT方法介于两者之间。     

断级滑行艇水动力特性的初步计算研究

利用数值手段对二维断级滑行艇模型的绕流场进行模拟,并针对不同攻角及断级高度的模型进行对比计算。不同模型的计算结果具有明显差异性,能较好表现出模型参数的变化对模型水动力特性的影响。分析断级的作用机理,并论述断级后脱体涡的强度和范围以及模型参数不同而引起的滑行面压力分布的差异。     

Measuring transport related CO2 emissions induced by online and brick-and-mortar retailing

We develop a method for empirically measuring the difference in transport related carbon footprint between traditional and online retailing (“e-tailing”) from entry point to a geographical area to consumer residence. The method only requires data on the locations of brick-and-mortar stores, online delivery points, and residences of the region’s population, and on the goods transportation networks in the studied region. Such data are readily available in most countries. The method has been evaluated using data from the Dalecarlia region in Sweden, and is shown to be robust to all assumptions made. In our empirical example, the results indicate that the average distance from consumer residence to a brick-and-mortar retailer is 48.54 km in the studied region, while the average distance to an online delivery point is 6.7 km. The results also indicate that e-tailing increases the average distance traveled from the regional entry point to the delivery point from 47.15 km for a brick-and-mortar store to 122.75 km for the online delivery points. However, as professional carriers transport the products in bulk to stores or online delivery points, which is more efficient than consumers’ transporting the products to their residences, the results indicate that consumers switching from traditional to e-tailing on average reduce their transport CO₂ footprints by 84% when buying standard consumer electronics products.     

基于坐垫体压分布的驾驶员生理状态识别方法

提出一种基于坐垫体压分布识别长途驾驶过程中驾驶员生理状态的方法.开展长途驾驶模拟试验,采集9名被试者在驾驶过程中的坐垫体压分布数据,提取82维分类特征,再采用序列浮动前向选择算法从中选出55维最优特征子空间.试验结果表明,该方法能准确识别驾驶员生理状态,贝叶斯分类正确率可达93.37％.