Increased expression of the 20S proteasome in peripheral blood mononuclear cells of type 2 diabetic patients

Objective To investigate the dynamic expression of the 20S proteasome in peripheral blood mononuclear cells (PBMCs) of type 2 diabetic patients without vascular complications. Methods PBMCs were prepared from 30 type 2 diabetic patients and 30 nondiabetic controls. The general indexes including weight, height and blood pressure were recorded. Fasting plasma glucose, fasting plasma insulin and glycosylated hemoglobin were measured. The protein level of the 20S proteasome was measured by Western blotting. The mRNA expression levels of the 20S proteasome β1, β2 and β5 subunits were detected by real-time PCR. Results Compared with that in the nondiabetic controls, the protein level of the 20S proteasome was significantly increased in the diabetic patients and was positively associated with glycosylated hemoglobin. Conclusion Type 2 diabetic patients without vascular complications have an increased 20S proteasome expression, the significance of which needs to be explored by further study.     

智能交通灯控制系统设计与仿真

使用AHDL语言,目标器件选用FPGA器件,采用自上向下的设计方法,设计智能交通灯控制系统。以单片机C8051为控制核心,实现东西、南北的通行时间可调,倒计时显示通行时间,急车强行通过等功能。该系统具有设计周期短、可靠性很高、维护较方便、使用简单等诸多优点。     

HFF6137K86型客车骨架静动态有限元分析

建立全承载客车骨架的有限元壳单元模型,分析其静力、模态、频率响应和疲劳寿命。     

基于FPGA的实时互相关运算器

以光纤传感系统空间定位问题的研究为背景,探讨了互相关算法在大规模现场可编程门阵列（FPGA）的实现方案,设计出流水线操作的互相关运算器,并应用VHDL语言实现了互相关运算器.该互相关运算器在64 MHz的时钟下,能够对二路监测信号进行互相关处理,实时完成128点探测距离的互相关运算,为光纤传感系统的后续空间准确定位奠定了基础.利用大规模的FPGA硬件资源丰富特点,用硬件电路实现互相关运算,有效提高了数据处理速度,实现了数据检测的实时性,有效解决光纤干涉仪传感系统中空间信息稳定实时提取的难题.     

渐开线螺旋齿轮Pro／E参数化造型方法

介绍了在Pro／E环境下,实现渐开线螺旋齿轮精确造型的方法和步骤,从原理出发,利用方程建立渐开线及螺旋线,从而保证了渐开线齿轮齿形的准确性．通过建立齿轮中各变量与齿轮基本参数的关系,实现了不同模数、齿数、螺旋角的齿轮以及变位齿轮快速造型．参数化设计方法有利于产品的系列化结构设计及修改原始设计方案．     

利用Pro/E和VRML实现齿轮泵虚拟装配技术

虚拟装配设计是装配设计的技术革新,它利用计算机将装配设计过程扩展到虚拟三维空间,能动态观察产品的各个细节。本文以齿轮泵虚拟装配为例,利用三维造型系统Pro/E建立模型,阐述了VRML与Pro/E建模方法,对转化成VRML模型文件进行优化与压缩,VRML动画实现,进行装配中的干涉检查,并完成其虚拟装配过程。此方案为复杂机械产品的虚拟装配提供了一种可借鉴的技术与方法。     

基于FPGA的以太网接口数据采集器设计与实现

基于FPGA的以太网接口数据采集器为水下声信号的采集和记录及水下声环境的分析提供了一种新的解决方案。着重研究了基于FPGA的以太网接口三通道数据采集和存储记录系统的设计和实现方法。     

FPGA技术在能谱探头测试系统中的应用

介绍了一种基于自然伽玛能谱电路和地面计算机系统部分功能的、用来检测能谱探头的辅助性检测系统。系统采用了FPGA芯片和集成USB功能的单片机来设计和实现。文中详细叙述了系统原理和FPGA内部逻辑。     

DSP数据传输在分布式信号处理中的应用

本文介绍TADSP—TS20XS数据传输的几种方式,即以CPU内核写或者DMA方式通过链路口或者外总线的方式进行数据传送。论述了其在分布式信号处理中的应用,并说明了传输标准对于多DSP互连的重要性,以利于系统的升级和维护。     

Parameterisation of clastic sediments including benthic structures

The sediment transport processes in the south-western Baltic Sea are predicted by means of a numerical model in the project DYNAS. There are two sediment parameters that influence the results of modelling remarkably: critical shear stress velocity and bottom roughness. This paper presents the way how to parameterise these factors and extrapolate them into the investigation area. The critical shear stress velocity is parameterised basing on grain size data, combining approximations after Hjulström [Hjulström, F., 1935: Studies in the morphological activity of rivers as illustrated by the river Fyris. Geological Institution of University of Uppsala: Bulletin (25): 221–528.], Shields [Shields, A., 1936: Anwendung der Ähnlichkeits-Mechanik und der Turbulenzforschung auf die Geschiebebewegung. Mitteilungen der Preussischen Versuchsanstalt für Wasserbau und Schiffahrt (26): 26 pp.] and Bohling [Bohling, B., 2003: Untersuchungen zur Mobilität natürlicher und anthropogener Sedimente in der Mecklenburger Bucht. unpublished doctoral thesis, Mathematisch-Naturwissenschaftliche Fakultät, Ernst-Moritz-Arndt-Universität Greifswald/Germany, 156 pp.]. The roughness length, in the case of absence of macro zoo-benthos and their structures, is parameterised basing on grain size too employing Soulsby [Soulsby, R.L., 1997: Dynamics of Marine Sands: a Manual for Practical Applications. London, Thomas Telford Publications. 249 pp.], Nielsen [Nielsen, P., 1983: Analytical determination of nearshore wave height variation due to refraction shoaling and friction. Coastal Engineering 7, 233–251.] and Yalin [Yalin, M.S., 1977: Mechanics of Sediment Transport. Pergamon Press, New York. 298 pp.]. No equivalent simple parameterisations for biologically caused bed roughness exist. Here, findings of Friedrichs [Friedrichs, M., 2004: Flow-induced effects of macro zoo-benthic structures on the near-bed sediment transport. Dissertation, Universität Rostock, 80 S.] and estimations by the DYNAS biologists group were combined in order to derive roughness lengths from abundance measurements of four previously selected key species which represent the originators of the dominating benthic structures at the sea floor in the south-western Baltic Sea. Critical shear stress velocity and bed roughness are known at few sample sites only. They were extrapolated into the larger investigation area using a proxy-target concept. The mean near bottom milieu (bathymetry, median grain size, salinity, oxygen) which was derived using results from numerical modelling serves as the proxy. Since the milieu parameters are measured at the sampling sites for which the target parameters have been determined, a combined hierarchical and supervised classification was employed to transfer the local knowledge into the unknown investigation area.