On the fluid-structure response of elastic-plastic ship sides subjected to impact loads

This paper presents a simplified numerical model capable of analysing the interaction between the structural dynamic response of elastic-plastic struck plate wall of a fluid tank subjected to wedge impact and the resulting fluid motion. The Variational Finite Difference Method (VFDM) is applied to analyse the structural dynamics of the struck plate and 2-D linear potential flow theory is used to study the resulting fluid motion and its effects on the structural dynamics of the struck plate. Experiments of a wedge indenter impacting with both empty and 90% filled tanks are carried out to study the structural deformation of the struck plate. The accuracy of the developed numerical model is validated with published results and experimental results, and good agreement is achieved. Through the comparison of the impact behaviour of empty and partially filled water tank, it is found that the resulting water motion helps to reduce the structural deformation of the struck plate since part of the impact energy is dissipated by the resulting water motion. Parametric studies are performed to investigate the effect of impact velocity and water level on the structural dynamics of the struck plate of a partially filled water tank. A case study is also conducted to demonstrate the potential application of the proposed method in analysing ship-ice impact problems.     

Experimental study of freak wave impacts on a tension-leg platform

This study investigates the freak wave impinging on a tension-leg platform through wave flume experiments. The freak waves are generated using the focused wave theory. By adjusting the wave focusing location, different incident wave scenarios at the structure location are produced. Simultaneous measurements of wave shape evolutions upon impingement, wave impact pressures on the platform deck, platform motions and tether forces are carried out for synchronized analyses of the wave kinematics/dynamics and structural responses. The variation of these parameters with the incident wave profile is studied. It is found that although applying less intensive local impact pressures as compared to the highly-breaking freak wave, the slightly-breaking or non-breaking freak wave imposes the same level of adverse effect on the platform's global stability in terms of motions and tether forces. In addition, the high-crest freak wave causes violent motions of the floating platform, which are likely to induce snap loads of large amplitude and high occurrence frequency in tethers. The published results would provide useful benchmarks for validating numerical and analytical models.     

城市物流服务站交通影响分析方法及应用

为有效地解决城市物流服务站的交通影响分析问题，在总结国内外研究成果基础上，提出了城市物流服务站交通影响分析的工作程序．用物流处理量作为实施交通影响分析的前提条件,针对交通服务水平不足以表征城市物流服务站对交通的影响程度，以交通影响度代之，并给出了相应定义与计算方法,讨论了包括改善邻近交叉口的交通组织、合理设置物流服务站进出口与道路交通标志标线等在内的减小城市物流服务站交通影响程度的措施．     

TSH RECEPTOR GENETIC ALTERATIONS IN THE AUTONOMOUSLYFUNCTIONING THYROID ADENOMAS

Objective To determine the relationship between TSH receptor gene mutations and autonomously functioning thyroid adenomas (AY‘]rAs). Methods The thyroid samples from 14 cases of diagnosed AFTAs were analyzed, with normal thyroid specimens adjacent to the tumors as controls. The 155 base pairs DNA fragments which encompassed the third cytoplasmic loop and the sixth transmembrane segments in the TSH receptor gene exon 10 were amplified by Polymerase chain reaction (PCR) and analyzed by the single-strand conformation polymorphism (SSCP). Direct sequencing of the PCR products was performed with Prism Dye Terminator Cycle Sequencing Core Kit.Results 6 of 14 AFTA specimens displayed abnormal migration in SSCP analysis. In sequence analysis of 3 abnormally migrated samples, one base substitution at nucleotide 1957 (A to C) and two same insertion mutations of one adenosine nucleotide between nucleotide 1972 and 1973 were identified. No mutations were found in controls. Conclusion This study confirmed the presence of TSH receptor gene mutations in AFTAs; both one-point substitution mutation and onebase insertion mutation were found to be responsible for the pathogenesis of AFTAs.     

人湿尺骨干在冲击压缩实验下的力学性能及规律

目的探讨人湿尺骨密质骨在高应变率下的力学性能及其分布规律。方法用分离式Hopkinson压杆(SHPB)技术对人湿尺骨密质骨进行了应变率在.ε=1.2×103/s条件下的冲击压缩试验。结果尺骨密质骨在高应变率下的力学性能随其纵向位置变化而呈现出中间强两端弱的分布,最强的位置约在距近端1/3处,且近端强于远端。与静态结果的比较表明,尺骨密质骨对应变率有较大的依赖性。结论在冲击压缩力作用下,尺骨的两端,尤其是远端容易骨折。     

浅谈交通运输企业运用环境会计问题

要想实现环境和经济协调持续发展的奋斗目标,就很有必要将环境会计理论运用到交通运输业会计理论体系中。从环境会计兴起与发展谈起,对交通运输企业运用环境会计的必要性、内容及会计信息的披露方式进行了论述。     

十二指肠胃反流对大鼠胃黏膜细胞增殖与凋亡及相关基因表达的影响

目的　探讨十二指肠胃反流 (DGR)引起大鼠胃黏膜损伤及癌变的发病机制。方法　健康成年雄性SD大鼠 (75只 )随机分为两组 :①DGR模型组 (5 5只 ) ,根据手术造模方式及反流量大小分为全反流组与部分反流组。②假手术对照组 (2 0只 )。采用pH监测仪测定胃液 pH ,用酶法测定胃液胆汁酸 (TBA) ,确定DGR模型成功。进行为期 3个月和 9个月胃黏膜损伤的动态观察。采用免疫组化方法分析不同病变胃黏膜组织PCNA、Bcl 2蛋白的表达。采用TUNEL技术观察胃黏膜细胞凋亡情况。结果　DGR模型大鼠胃液pH及TBA明显升高 (P <0 .0 1) ,证明DGR模型成功。模型大鼠病理改变出现浅表性胃炎→萎缩性胃炎→异型增生的动态演变过程。正常胃黏膜→浅表性胃炎→萎缩性胃炎 ,增殖指数 (PI)、凋亡指数 (AI)均呈上升趋势 (P <0 .0 5 ) ,PI与AI呈正相关 (r=0 .6 8,0 .71)。从萎缩性胃炎→异型增生 ,PI仍显著增加 ,在异型增生时AI突然下降 ,AI/PI也明显降低 (P <0 .0 1) ,AI与PI呈负相关 (r=- 0 .5 7)。萎缩性胃炎及异型增生时PCNA、Bcl 2蛋白表达显著高于假手术对照组及浅表性胃炎组 (P <0 .0 5 ) ,萎缩性胃炎与异型增生之间PCNA、Bcl 2表达差异无显著性 (P >0 .0 5 )。结论　细胞增殖与凋亡调节紊乱可能是十二指肠反流液造成胃黏膜损伤?     

上皮性卵巢癌中P53蛋白的表达及临床意义

目的　探讨抑癌基因P5 3蛋白在上皮性卵巢癌发生、发展中的作用。方法　对 74例上皮性卵巢癌应用免疫组化方法检测P5 3蛋白的表达。结果　上皮性卵巢癌中P5 3蛋白有一定的表达缺失 ,在G1、G2级组织表达率 (90 .6 2 % )高于G3级 (6 6、6 7% ) ,二者差异有显著性 (P <0 .0 5 ) ;不同的临床分期中 ,Ⅰ、Ⅱ期阳性表达为 2 2 / 2 4 (91、6 7% ) ,Ⅲ、Ⅳ期阳性表达为 35 / 5 0 (70 % ) ,二者差异有显著性 (P <0 .0 5 )。在浆液性和黏液性两种不同的组织类型间 ,表达率分别为 82 .98%和 6 6 .6 7% ,二者无明显差别。结论　P5 3蛋白的表达缺失在上皮性卵巢癌发生、发展过程有一定的作用 ,并且与病变进展和分化有关     

列车蓄电池箱的有限元分析和实验测试

通过有限元建模，对列车电池箱进行冲击载荷的有限元分析，得出各个方向冲击应力和箱体变形，并和实验数据进行比较，为进行电池箱的优化设计提供参考。     

P53和Sialyl Lewis-X表达与甲状腺乳头状癌侵袭转移的关系

目的　探讨甲状腺乳头状癌(PTC)组织中P53和唾液酸化路易斯- X(SLeX)蛋白表达与肿瘤侵袭、转移的关系。方法　应用免疫组织化学催化信号放大(CSA)方法,对46例PTC、20例结节性甲状腺肿(NG)、20例慢性淋巴细胞甲状腺炎(CLT)和15例正常甲状腺组织(NT)进行了 P53 和 SLeX基因蛋白检测。结果　在 PTC中,P53 和 SLeX表达阳性率分别为65.2%(30/46)和69.6%(32/46),显著高于 NG、CLT和 NT(P<0.05);P53 和 SLeX表达阳性与PTC的侵袭、转移呈显著正相关(P<0.05)。结论　P53 和 SLeX阳性表达与 PTC侵袭、转移密切相关,检测 P53 和SLeX蛋白表达可作为判断PTC预后的参考指标。